CAS: 1641-09-4; 3-Thiophenecarbonitrile

相似化合物

498-62-4 88-13-1 73229-39-7

上下游产品

CAS号498-62-4 3-噻吩甲醛 | CAS号872-31-1 3-溴噻吩 | CAS号143-33-9 氰化钠 | CAS号6165-69-1 3-噻吩硼酸 | CAS号3012-37-1 硫氰酸苯甲酯 | CAS号71637-34-8 3-噻吩甲醇 | CAS号75-86-5 丙酮氰醇 | CAS号557-21-1 氰化锌 | CAS号773837-37-9 sodium cyanide | CAS号56182-43-5 2-溴噻吩-3-腈 | CAS号51460-47-0 3-噻吩甲酰胺 | CAS号24044-76-6 噻吩-3-硫代酰胺 | CAS号88-13-1 3-噻吩甲酸 | CAS号27757-86-4 3-氨甲基噻吩 | CAS号58905-71-8 N'-羟基噻吩-3-羧酰亚胺 | CAS号36050-09-6 5-nitrothiophen... | CAS号54610-58-1 ethyl thiophene... | CAS号57059-14-0 4,6-二氯-2-(噻吩-3-基)嘧啶 | CAS号53562-50-8 2-methylthiophe...

3-甲基噻吩置于氨,Sulfur,苯体系中,340.0 °C,2.45 Mpa 条件下,反应生成3-氰基噻吩
参考文献:Production Of Nitriles
标题:Production Of Nitriles

专利信息

专利号:US-6995289-B2
优先权日:2000-08-02
标题 :Process for synthesis of alpha, beta-unsaturated ketones
发明人：PATEL IAN; HOPES PHILIP
权利人:ASTRAZENECA AB
摘要:A method for the synthesis of an α,β-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low temperature. The synthesis is used in a process for making substituted 1,4-dihydropyridines wherein a vinylogous amide is prepared by reacting a 1,3-cyclohexanedione with a phenylethylamine. The α,β-unsaturated ketone can be reacted with a vinylogous amide to form a 1,5-diketone which can be converted to a substituted 1,4-dihydropyridine.

专利号:US-8835476-B2
优先权日:2005-03-04
标 题:Synthesis of novel antimicrobials
发明人：WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
权利人:WU FAN; WEAVER DONALD; BARDEN CHRIS; MCMASTER CHRISTOPHER; BYERS DAVID; HENNEBERRY ANNETTE; BAN FUQIANG
摘要:The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable binding interaction at the active site of the enzyme. In particular, the compounds present the following formula (I) where V, W, X, Y and Z can be independently C, S, N or O and P1, P2 and P3 are ligands to bind to the three points of the proposed pharmacophore model. They can be chosen from a variety of groups.

专利号:US-7598394-B2
优先权日:2003-11-11
标题 :Process for the synthesis of imidazoles
发明人：DOLBY LLOYD J; ESFANDIARI SHERVIN; GARST MICHAEL E
权利人:ALLERGAN INC
摘要:The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.

专利号:US-7880017-B2
优先权日:2003-11-11
标 题 :Process for the synthesis of imidazoles
发明人：DOLBY LLOYD J; ESFANDIARI SHERVIN; GARST MICHAEL E
权利人:ALLERGAN INC
摘要:The present invention provides a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound. Such imidazoles are useful pharmacologically-active compounds and/or intermediates for the preparation of pharmacologically-active compounds.

专利号:US-7074931-B2
优先权日:2000-08-02
标 题:Process for asymmetric synthesis of substituted 1,4 -dihydropyridines
发明人：PATEL IAN; ASHWORTH IAN; LEVIN DANIEL
权利人:ASTRAZENECA AB
摘要:A process is described for reacting a vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound to form an 1,5-diketone which is converted to a 1,4-dihydropyridine. Asymmetric substituted 1,4-dihydropyridines are synthesized by the process by preparing an asymmetric vinylogous amide by reacting a 1,3-cyclohexanedione with a substantially homo-chiral phenylethylamine. Reaction of the asymmetric vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound forms an asymmetric 1,5-diketone. The 1,5-diketone is converted to an asymmetric substituted 1,4-dihydropyridine.

专利号:US-2016223559-A1
优先权日:2015-02-02
标题:Tetrazine-containing compounds and synthetic methods thereof
发明人：DEVARAJ NEAL K; WU HAOXING; YANG JUN
权利人:UNIV CALIFORNIA
摘要:Described herein are tetrazine derivatives and efficient synthetic methods of synthesis thereof using elimination-Heck cascade reaction. Provided herein is the synthesis of conjugated tetrazines from the tetrazine derivatives. Also provided herein are methods of use of the conjugated tetrazines as fluorogenic probes for live-cell imaging.