CAS: 2835-97-4; 2-Amino-3-Methylphenol

上下游产品

2-硝基-3-甲基苯酚 3-Methyl-2-Nitrophenol 4920-77-8
邻甲苯胺 O-Toluidine 95-53-4

5-Methyl-2,3-Dioxo-1,4-Benzoxazine置于盐酸体系中,化学反应 3.0H,反应生成2-氨基-3-甲基苯酚
参考文献:带有苯并恶唑酮骨架的combretastatin A-4类似物:合成,结构和生物学活性
标题:带有苯并恶唑酮骨架的combretastatin A-4类似物:合成,结构和生物学活性
摘要:为了设计和合成一类新的天然康普他汀a-4杂环类似物及其合成衍生物ave8062,选择了苯并恶唑酮环作为两个分子的b环生物立体替代的骨架.在boden的条件下,通过改良的wittig反应获得了28个顺式和反式-苯乙烯基苯并恶唑酮的文库.确定了在苯并恶唑酮核的4,5,6或7位上带有3,4,5-三甲氧基-,3,4-二甲氧基-,3,5-二甲氧基-和4-甲氧基苯乙烯基片段的新合成的化合物的结构根据光谱和x射线数据.在体外进行了检查针对不同的细胞系styrylbenzoxazolones的细胞毒性.二苯乙烯衍生物16 Z,(z)-3-甲基-6-(3,4,5-三甲氧基苯乙烯基)-2(3 H)-苯并恶唑酮显示了该系列中最高的抗增殖潜力,对康普他汀耐药细胞株ht-的ic 50为0.25μm. 29,针对hepg2的0.19μm,针对ea.Hy926的0.28μm和针对k562细胞的0.73μm.此外,流式细胞仪分析的结果证实了16
Doi:10.1016/j.Ejmech.2016.05.012

专利信息

专利号:US-6946562-B2
优先权日:2001-12-12
标 题:Synthesis of peptoid substituted azole compounds
发明人：DIEHL DONALD R; NIGER ROBERT J; SCHMITTHENNER HANS F; SONNEFELD WILLIAM J; DUNLAP RICHARD P
权利人:EASTMAN KODAK CO
摘要:Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.

专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人：CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

专利号:US-4764263-A
优先权日:1987-05-18
标 题:Electrochemical synthesis of substituted aromatic amines in basic media
发明人：GREGORY THOMAS D; STUTTS KENNETH J
权利人:DOW CHEMICAL CO
摘要:Substituted amino aromatic compounds such as 3-amino-4-hydroxybenzoic acid are prepared by electrolytically reducing the corresponding nitro aromatic compound in a basic medium at temperatures below 60° C. and current densities greater than 50 milliamps per square centimeter. The aminohydroxybenzoic acids are useful in the preparation of polybenzoxazoles which are used to make fibers and composites having high strength and thermal stability.

专利号:US-2003187188-A1
优先权日:2001-12-12
标 题:Synthesis of peptoid substituted azole compounds

专利号:US-2004102650-A1
优先权日:2001-07-06
标 题:Solid phase synthesis of arylretinamides

专利号:US-7071145-B2
优先权日:2001-09-25
标 题:Thermosensitive recording material, and synthesis method of oligomer composition for the recording material
发明人：MORITA MITSUNOBU; HAYAKAWA KUNIO; TORII MASAFUMI; NARUSE MITSURU
权利人:RICOH KK
摘要:A thermosensitive recording material comprising a thermosensitive layer provided on a substrate, and the thermosensitive layer comprises as main ingredients a leuco dye and a developer to make colored state of said leuco dye when heated, wherein the developer is an oligomer composition obtained from the reaction of a polyvalent isocyanate compound represented by following Formula (I) with an aromatic amine represented by following Formula (II); n nwhere X represents a try- or more-valent group, a represents an integer numeral of 3 or more, b and c represent respectively integer numerals in the range of 0 to 5 and they satisfy a relation of b+c=1 to 5, Z represents hydrogen atom, alkyl group, allyl group or aryl group, and the aryl group may include condensed ling structure thereof, and d represents an integer numeral in the range of 0 to 4. This developer shows excellent reliabilities of both image and background area, and also shows an excellent color-developing characteristics (color developing sensitivity and image density).