CAS: 33069-62-4; Paclitaxel

上下游产品

CAS号135365-62-7 1-hydroxy-7β-tr... | CAS号439813-57-7 (2'R,3'S)-2'-et... | CAS号158722-23-7 紫杉醇缩合物 | CAS号1122-58-3 4-二甲氨基吡啶 | CAS号148930-55-6 7-O-(三乙基甲硅烷基)紫杉醇 | CAS号307923-51-9 2'-O-benzoyl-3'... | CAS号718627-80-6 | CAS号32981-86-5 10-脱乙酰基巴卡丁 III；... | CAS号32981-85-4 (2R,3S)-3-苯甲酰氨基... | CAS号71629-92-0 7-表-10-脱乙酰浆果赤霉素III | CAS号27548-93-2 巴卡丁III | CAS号105454-04-4 7-表紫杉醇 | CAS号103150-32-9 TAXOL SIDE CHAI... | CAS号78432-77-6 10-去乙酰紫杉醇 | CAS号100431-55-8 2'-O-[(2,2,2,-三... | CAS号100449-86-3 2',7-双-O-{[((2,...

4-二甲氨基吡啶置于盐酸,水体系中,用 乙醇 作为反应溶剂,化学反应 2.42H,以100%的收率获得产物紫杉醇
参考文献: A Catalytic Asymmetric Method For The Preparation Of The Paclitaxel (Taxol) C-13 Side-Chain Derivatives And Its Use In The Preparation Of Taxane Derivatives[fr] Procédé Asymétrique Catalytique Pour La Préparation De Dérivés De La Chaîne Latérale C-13 Du Paclitaxel (Taxol) Et Son Utilisation Dans La Préparation De Dérivés Du Taxane
标题: A Catalytic Asymmetric Method For The Preparation Of The Paclitaxel (Taxol) C-13 Side-Chain Derivatives And Its Use In The Preparation Of Taxane Derivatives[fr] Procédé Asymétrique Catalytique Pour La Préparation De Dérivés De La Chaîne Latérale C-13 Du Paclitaxel (Taxol) Et Son Utilisation Dans La Préparation De Dérivés Du Taxane
摘要:一种新的催化不对称两步或一锅法,用于制备紫杉醇(紫杉醇)的c-13侧链和通式(i)的衍生物,其形式为酸,盐或酯,其中r代表芳基或烷基,R1代表芳基或烷基,Y代表o,H或烷基,X1代表-Ch2-Ph,烷基,芳基,Sir3(其中硅烷基是常见的保护基)或其他适当的保护基.

专利信息

专利号:US-8207358-B2
优先权日:2005-11-04
标 题:Methods for the preparation of taxanes using chiral auxiliaries
发明人：LOURDUSAMY METTILDA; CARON GAETAN
权利人:LOURDUSAMY METTILDA; CARON GAETAN; ACCORD HEALTHCARE LTD
摘要:The present invention relates to a stereoselective synthesis of novel β-lactam dimers as useful precursors for the preparation of paclitaxel, docetaxel, and analogues thereof. More particularly, the new β-lactams are prepared from readily available and enantiomerically pure chiral auxiliaries. The β-lactams are then reacted with a suitably protected taxane to produce diastereomerically enriched side chain-bearing taxanes. Finally, the chiral auxiliary is cleaved and protecting groups are removed to provide the desired taxane.

专利号:US-2025263747-A1
优先权日:2025-03-18
标 题:Higher yields and improved recombinant adeno-associated virus vectors by altering intracellular trafficking in producer cells.
发明人：WARD PETER
权利人:WARD PETER
摘要:Chemical agents are added to standard production methods for recombinant adeno-associated viral vector to alter intracellular trafficking pathways in producer cells. This achieves, per producer cell, the synthesis of more genome containing vector particles and particles that are better transducing agents. Vector so produced also has: a greater propensity for export out of the producer cell, a more gradual transduction of infected cells, an enhanced ability for integration into the genome of cells that are coinfected by the adeno-associated virus, and an increased probability of transforming cells with multiple vectors.

专利号:US-9359376-B2
优先权日:2011-04-08
标题:Substituted methylformyl reagents and method of using same to modify physicochemical and/or pharmacokinetic properties of compounds
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; HOLLINGER FRANK PETER; SPHAERA PHARMA PTE LTD
摘要:The present invention relates to the synthesis and application of novel chiral/achiral substituted methyl formyl reagents to modify pharmaceutical agents and/or biologically active substances to modify the physicochemical, biological and/or pharmacokinetic properties of the resulting compounds from the unmodified original agent.

专利号:US-6448417-B1
优先权日:1998-05-01
标题 :Methods and useful intermediates for paclitaxel synthesis from C-7, C-10 di-cbz 10-deacetylbaccatin III
发明人：SISTI NICHOLAS J; BRINKMAN HERBERT R; MCCHESNEY JAMES D; CHANDER MADHAVI C; LIANG XIAN; ZYGMUNT JAN
权利人:NAPRO BIOTHERAPEUTICS INC
摘要:The present invention relates to a method of producing paclitaxel or a paclitaxel analog comprising the esterification of C-7, C-10 di-CBZ 10-deacetylbaccatin III with an N-carbamate protected, C-2-protected 3-phenyl isoserine side chain. The C-7, C-10 carbobenzyloxy groups are then replaced with hydrogen and an acyl group is substituted at the C-3' nitrogen. The resulting compound is acylated at the C-10 hydroxyl position, and deprotected at the C-2' position by replacing the hydroxyl protecting group with hydrogen to produce paclitaxel or a paclitaxel analog. The present invention also relates to alternative methods of acylating a 10-hydroxy paclitaxel analog. The first method comprises dissolving a 10-hydroxy paclitaxel analog in an acceptable ether solvent therefor to form a first solution at a first temperature. The first solution is then cooled to a second temperature, and an alkali base is added to form an intermediate compound having a metal alkoxide at the C-10 position thereof, after which an acylating ageht is then added. The second method comprises dissolving a 10-hydroxy paclitaxel analog in an acceptable ether solvent therefor. An alkali salt is added, and a trialkyl amine base or pyridine is next added, followed by the addition of an acylating agent. The present invention is additionally directed to a C-10 metal alkoxide chemical intermediate for use in producing paclitaxel or paclitaxel analogs.

专利号:EP-2752422-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives

专利号:EP-2552931-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives