CAS: 41939-61-1; N1-Methyl-4-Nitrobenzene-1,2-Diamine

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N-甲基-2,4-二硝基苯胺置于甲酸,三乙胺体系中,用 乙腈 作为反应溶剂,化学反应 3.0H,以99%的收率获得产物n1-甲基-4-硝基苯-1,2-二胺
参考文献:Synthesis Of Benzo[1,2-D;3,4-D']Diimidazole And 1H-Pyrazolo[4,3-B]Pyridine As Putative A2A Receptor Antagonists
标题:Synthesis Of Benzo[1,2-D;3,4-D']Diimidazole And 1H-Pyrazolo[4,3-B]Pyridine As Putative A2A Receptor Antagonists
摘要:报告了假定腺苷受体拮抗剂6-甲基-7-[1,2,3]三唑-2-基-1,6-二氢苯并[1,2-D;3,4-D']二咪唑(10)和5-噁唑-2-基-1H-吡唑[4,3-B]吡啶-3-基胺(16)的合成及其结合亲和力.这些标题化合物分别由商业可得的1-氯-2,4-二硝基苯(1)和2-氯-6-甲氧基-3-硝基吡啶(11)制备而成,但对腺苷a1和a2A受体未表现出亲和力.
DOI:10.1039/b707599E

专利信息

专利号:US-9643932-B2
优先权日:2011-09-26
标 题:Process for the preparation of bendamustine hydrochloride
发明人：MISHRA BHUWAN BHASKAR; KACHHADIA NIKUNJ SHAMBHUBHAI; TOMAR VINOD SINGH; LAHIRI SASWATA
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the synthesis of bendamustine, in particular, bendamustine hydrochloride of the formula (VI) and its intermediate 1-methyl-5-[bis(2-chloroethyl)amino]-1H-benzimidazol-2-yl]lithium butanoate of formula (V), both having a purity of ≧99%, which is simple, convenient, economical, does not use hazardous chemicals and is industrially viable.

专利号:CN-102993102-A
优先权日:2011-09-16
标题 :Synthesis of [1-methyl-2-(8'-octyl hydroxamic acid)-5-N,N-di(2'-chloroethyl)]-1H-benzimidazole