CAS: 4519-39-5; 2,3-Difluorobenzoic Acid

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CAS号124-38-9 二氧化碳 | CAS号367-11-3 邻二氟苯 | CAS号1489-53-8 1,2,3-三氟苯 | CAS号61079-72-9 2,3,4-三氟苯甲酸 | CAS号2646-91-5 2,3-二氟苯甲醛 | CAS号65-85-0 苯甲酸 | CAS号455-38-9 间氟苯甲酸 | CAS号65-85-0 苯甲酸 | CAS号75853-18-8 2,3-二氟苯甲醇 | CAS号113211-94-2 2,3-二氟苄基溴 | CAS号18355-73-2 2,3-二氟苯甲酰氯 | CAS号858935-15-6 2-(2,3-二氟苯基)-1H...

1,2,3-三氟苯置于正丁基锂,氨,Sodium体系中,用 吡啶 作为反应溶剂,化学反应 0.25H,反应生成 2,3-二氟苯甲酸
参考文献:Fragmentation Of Radical Anions Of Polyfluorinated Benzoates
标题:Fragmentation Of Radical Anions Of Polyfluorinated Benzoates
摘要:A Comprehensive Study Of The Symmetry Forbidden Fragmentation Of Short-Lived Radical Anions (Ras) Has Been Undertaken For The Complete Set Of Polyfluorinated Benzoates (C6Fnh5-Nco2-,N = 1-5) The Decay Rate Constants (K(C)) Of Ras Have Been Determined In Aqueous Alkaline Solution (Ph 13.4) By Electron Photoinjection (Epi) From Mercury Electrodes And Were Found To Increase Dramatically From Less Than Or Equal To 3 X 10(3) S(-1) (3-F-C6H4Co2-) To (1.2 +/-0.8) X 10(9) S(-1) (C6F5Co2-). The Regioselectivity Of C-F Bond Cleavage In The Ra Fragmentation Has Been Revealed By Structure Assignment Of Reduction Products Of The Polyfluorinated Benzoic Acids By Na,K,And Zn In Liquid Nh3,As Well As By Zn In Aqueous Nh3 And Aqueous Alkaline Solutions. The K(C) Values Depend On The Position Of The Cleaved Fluorine To The Co2-Group Generally In The Order Para > Ortho > Meta,And To Sharply Increase If Adjacent Fluorine Atoms Are Present. The Observed Trends Reveal That The Kinetics Of The Ra Fragmentation Reaction Is Not Controlled By The Reaction Thermodynamics. Semiempirical Uhf/indo Calculations,The Validity Of Which Has Been Confirmed By Ab Initio Rohf/6-31+g Calculations,Were Done To Rationalize The Observed Trends. The Reaction Transition State (Ts) Was Considered To Arise From The Ra'S Ii And Sigma* States Crossing Avoided Due To Out-Of-Plane Deviation Of The Cleaving C-F Bond. The Satisfactory Linear Correlation (R = 0.96) Between The Model Reaction Energy Barrier E-A And Log K(C) Has Been Achieved With Modeling The Local Solvation Of The Co2-Group By Its Protonation.
DOI:10.1021/jp993361D

专利信息

专利号:US-6180830-B1
优先权日:1995-11-08
标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
发明人：JACQUOT ROLAND
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

专利号:US-7897762-B2
优先权日:2006-09-14
标 题:Kinase inhibitors useful for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:DECIPHERA PHARMACEUTICALS LLC
摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-12337036-B2
优先权日:2018-01-01
标题:Compounds and methods for trans-membrane delivery of molecules
发明人：ZIV ILAN; GRIMBERG HAGIT; DUBROVSKY JOSEPH
权利人:APOSENSE LTD
摘要:The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.

专利号:WO-9731891-A1
优先权日:1996-03-01
标 题:Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
发明人：LYNCH JOSEPH E; SHI YAO-JUN; WELLS KENNETH M
权利人:MERCK & CO INC; LYNCH JOSEPH E; SHI YAO JUN; WELLS KENNETH M
摘要:The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.

专利号:US-5777123-A
优先权日:1996-03-01
标题 :Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
发明人：LYNCH JOSEPH E; SHI YAO-JUN; WELLS KENNETH M
权利人:MERCK & CO INC
摘要:The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.