2-乙基吡嗪置于盐酸,Potassium Permanganate体系中,用 水 作为反应溶剂,化学反应生成 吡嗪-2-羧酸甲酯 参考文献:Experimental Thermochemical Study Of Three Monosubstituted Pyrazines 标题:Experimental Thermochemical Study Of Three Monosubstituted Pyrazines 摘要:The Standard (Pdegrees = 0.1 Mpa) Molar Enthalpies Of Formation Of Liquid Pyrazinecarbonitrile And Of Crystalline Pyrazinecarboxylic Acid And Pyrazinamide Were Measured,At T = 298.15 K,By Static Bomb Calorimetry And The Standard Molar Enthalpies Of Vaporization Or Of Sublimation,At T = 298.15 K,Were Obtained Using Calvet Microcalorimetry. These Values Were Used To Derive The Respective Standard Molar Enthalpies Of Formation In Gaseous Phase. (C) 2004 Elsevier Ltd. All Rights Reserved. DOI:10.1016/j.Jct.2004.08.006
专利号:EP-3686190-A1 优先权日:2013-07-11 标 题 :Synthesis of therapeutically active compounds
专利号:US-2008200475-A1 优先权日:2005-03-28 标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors 发明人:ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH 权利人:PFIZER 摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.