CAS: 6979-94-8; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2-Amino-6-Oxo-3,6-Dihydro-9H-Purin-9-yl)Tetrahydrofuran-3,4-Diyl Diacetate

相似化合物

118-00-3 2140-71-8 38819-10-2

上下游产品

CAS号108-24-7 乙酸酐 | CAS号118-00-3 鸟苷 | CAS号335060-31-6 2',3',5'-tri-O-... | CAS号127-09-3 乙酸钠 | CAS号335060-20-3 2',3',5'-tri-O-... | CAS号335060-33-8 2',3',5'-tri-O-... | CAS号172224-98-5 2',3',5'-tri-O-... | CAS号4546-54-7 2-氨基嘌呤核苷 | CAS号5987-76-8 2',3',5'-三-O-乙酰... | CAS号35109-88-7 2-碘腺苷 | CAS号39809-25-1 喷昔洛韦 | CAS号59587-07-4 2-Azidoadenosine | CAS号37739-05-2 2-氯-N6-环戊基腺苷 | CAS号22164-16-5 Guanosine, 7-me... | CAS号65-46-3 胞嘧啶核苷 | CAS号28007-87-6 Guanosine,7,8-d... | CAS号7803-88-5 6-O-甲基鸟苷

2',3',5'-Tri-O-Acetyl-O6-[2-(Methylsulfonyl)Ethyl]Guanosine置于1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 乙腈 作为反应溶剂,化学反应 1.0H,以96%的收率获得产物2',3',5'-三乙酰鸟苷
参考文献:合成[2-15N]鸟苷和2'-脱氧[2-15N]鸟苷衍生物的有效方法.
标题:合成[2-15N]鸟苷和2'-脱氧[2-15N]鸟苷衍生物的有效方法.
摘要:在存在下2',3',5'-三-O-乙酰基-2-氟-O6-[2-(4-硝基苯基)乙基]肌苷(8)与[15N]苄胺的亲核加成消除反应通过用三氯化钌和高碘酸四丁铵处理,将三乙胺转化为高产率的n2-苄基[2-15N]鸟苷衍生物(13),将其进一步转化为n2-苯甲酰基[2-15N]鸟苷衍生物.2',3',5'-三-O-乙酰基-2-氟-06-[2-(甲硫基)乙基]肌苷(9)和6-氯-2-氟-9的相似反应顺序分别由鸟苷和-[15N]邻苯二甲酰亚胺钾制备的-(β-D-呋喃核糖基)-9H-嘌呤衍生物(11)提供了n2-邻苯二甲酰[2-15N]鸟苷衍生物(15; 62%)和9-(2,3,5-三-O-乙酰基-β-D-呋喃呋喃糖基)-6-氯-2-[15N]邻苯二甲酰亚胺基-9H-嘌呤(17; 64%).然后将化合物15和17有效地转化为2',3',5'-三-O-乙酰基[2-15N]鸟苷.相应的2'-脱氧衍
DOI:10.1081/ncn-100001437

专利信息

专利号:US-6951932-B2
优先权日:2001-10-25
标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines
发明人：MOORMAN ALLAN R
权利人:KING PHARMACEUTICALS RES & DEV
摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.

专利号:US-2003199686-A1
优先权日:2001-10-25
标题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines

专利号:US-8362203-B2
优先权日:2009-02-10
标 题:Non-natural peptides as models for the development of antibiotics
发明人：CUNNINGHAM PHILIP R; CHOW CHRISTINE SHARON; ABEYDEERA NUWAN DINUKA; LAMICHHANE TEK NARAYAN
权利人:UNIV WAYNE STATE; CUNNINGHAM PHILIP R; CHOW CHRISTINE SHARON; ABEYDEERA NUWAN DINUKA; LAMICHHANE TEK NARAYAN
摘要:Described herein are methods of screening one of the RNA hairpins in the small ribosomal subunit of bacteria to identify peptides that bind to it. The RNA hairpin target may be the 970 loop (aka helix 31 (h31)) or a modified version thereof. The identified peptides may inhibit protein synthesis and, therefore, may be used as a model for new antibiotics.

专利号:CA-2465264-C
优先权日:2001-10-25
标 题 :Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines

专利号:JP-2005511551-A
优先权日:2001-10-25
标题 :Synthesis of 2-aralkoxyadenosine and 2-alkoxyadenosine

专利号:US-5412088-A
优先权日:1989-11-20
标 题 :6-O-substituted guanosine derivatives
发明人：JONES ROGER A; FATHIP REZA; GAFFNEY BARBARA L
权利人:UNIV RUTGERS
摘要:The following species of N6-activated guanosine derivatives are disclosed: n 2-N-trifluoroacetamido-6-(4-nitrophenoxy)-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine n 2-N-trifluoroacetamido-6-pentafluorophenoxy-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine n 6-dimethylpyridinium-9-(2-deoxy-beta-D-erythropentofuranosyl)purine n These guanosine compounds are useful as precursors in the synthesis of a wide variety of antiviral and anticancer nucleosides such as 2-amino-2-deoxyadenosine or 6-thio-deoxyguanosine. Also disclosed are oligonucleotides containing the above nucleosides which are precursors to modified oligonucleotides which are useful as hybridization probes.