CAS: 93102-05-7; N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine

• 英文名称N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine
• 中文名称N-甲氧基甲基-N-(三甲基硅烷甲基)苄胺
• IUPAC名称N-benzyl-1-methoxy-N-((trimethylsilyl)methyl)methanamine
• 其它别名N-甲氧基甲基-N-(三甲基硅烷甲基)苄基胺; N-Methoxymethyl-N-(Trimethylsilylmethyl)Benzylamine
• CAS编号93102-05-7
• MFCD编号:MFCD00674005
• EINECS号:630-326-4
• 分子式:C13H23NOSi
• 分子量:237.41
• 产品CID: 1969712
• 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

• 相似结构搜索
• 产品信息参考;;
• InChIKey: RPZAAFUKDPKTKP-UHFFFAOYSA-N
• InChI=1S/C13H23NOSi/c1-15-11-14(12-16(2,3)4)10-13-8-6-5-7-9-13/h5-9H,10-12H2,1-4H3…
• 计算化学: 氢键受体数2.0氢键供体数0.0可旋转键数6.0

物理性质

• 沸点76 °C0.3 mm Hg(文献)
• 闪点104.2±21.8 °C
• 密度0.928 g/mL at 25 °C(文献)
• pKa:7.29±0.50(预测)
• PSA:12.47
• LogP:2.9699
• 折射率n 20/D 1.492(文献)
• 溶解性Soluble In Chloroform, Ethyl Acetate.
• 敏感性吸潮 & 光敏感
• 外观形态透明无色至淡黄色液体
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用作制造丙烯衍生物的有机合成中间体,作为治疗缺化学相关疾病的新型钠渠道阻塞剂.
• 性质描述无色液体,密度0.928,沸点76°C,折射率1.4915-1.4935,闪点66°C

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  严重眼刺激 类别2A
  易燃液体 类别4
  易燃液体 类别3
  致突变性 类别2
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H227 |可燃液体
  H226 |易燃液体和蒸气.
  H341 |怀疑导致遗传缺陷.
• 防范说明P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
• 危险等级3
• UN编号1993.0
• 危险品标志Xi
• 包装等级Ⅲ
• 安全声明26-37/39
• 危险类别码36/37/38
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 合成目标产物 N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylamine 主要起始原料 Formaldehyde And N-[(Trimethylsilyl)Methyl]Benzylamine
• 53215-95-5 = 93102-05-7
  反应条件:1.1 1 H,0 °C; 3 H,10 - 15 °C1.2 Reagents: Potassium Carbonate; Overnight,Rt
  标题:Oxazole Compound With Antifungal Activity And Preparation Method
  参考文献:China]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Water
  标题:Preparation Of Heterocyclyl-Substituted Diazabicyclooctanes Having Selective 5-Ht1Dα Antagonist Activity
  参考文献:World Intellectual Property Organization]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Catalysts: Potassium Carbonate; Rt -> 0 °C1.2 30 Min,0 °C; 1 H,0 °C; 20 Min,0 °C -> Rt
  标题:Improved Process For Production Of N-Methoxymethyl Trimethylsilylmethylamines By Base-Catalyzed Methoxymethylation With Paraformaldehyde In Methanol
  参考文献:Germany]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Water; 0.5 H,0 °C; 1 H,0 °C; 3 H,10 - 15 °C1.2 Reagents: Potassium Carbonate; 2 H
  标题:A Practical Large-Scale Synthesis Of (3R,4R)-4-(Hydroxymethyl)Pyrrolidin-3-Ol Via Asymmetric 1,3-Dipolar Cycloaddition
  作者:Kotian,Pravin L.; Lin,Tsu-Hsing; El-Kattan,Yahya; Chand,Pooran
  参考文献:Organic Process Research & Development 日期:2005 卷标:9(2) 页码:193-197]
  
  = 93102-05-7
  反应条件:1.1 Solvents: Acetonitrile; Rt; 16 H,Reflux; Reflux -> Rt1.2 Solvents: Water; 0 °C; 1 H,0 °C; 2 H,10 - 15 °C1.3 Reagents: Potassium Carbonate; 170 Min,Rt
  标题:Synthesis Of Novel 4-Substituted Imidazolidines
  作者:Gao,Bin-Heng; Chen,Ken; Xu,Liang
  参考文献:Hecheng Huaxue 日期:2011 卷标:19(3) 页码:291-294]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Water; 0 °C; 1 H,0 °C1.2 Reagents: Potassium Carbonate; -5 °C1.3 -5 °C; Overnight,-5 °C -> Rt
  标题:Method For Synthesizing N-Methoxymethyl-N-(Trimethylsilylmethyl)Benzylamine
  参考文献:China]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Water1.2 Reagents: Potassium Carbonate
  标题:Use Of N-[(Trimethylsilyl)Methyl]Amino Ethers As Capped Azomethine Ylide Equivalents
  作者:Padwa,Albert; Dent,William
  参考文献:Journal Of Organic Chemistry 日期:1987 卷标:52(2) 页码:235-44]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Water; 0 °C; 2 H,Rt
  标题:Preparation Of Pyrazolo[4,3-D]Pyrimidin-7(6H)-One Derivatives As Pde9 Inhibitors
  参考文献:World Intellectual Property Organization]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 20 Min,0 °C; 1 H,0 °C; 0 °C -> 15 °C; 15 Min,10 - 15 °C
  标题:Synthesis Of Methyl Pyrrolidine-3-Carboxylate
  作者:Xie,Honglei; Jia,Yunhong; Cai,Dong
  参考文献:Huaxue Tongbao 日期:2011 卷标:74(9) 页码:850-852]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Methanol
  标题:Small Molecule Inhibitors Of Myc/max Dimerization And Myc-Induced Cell Transformation
  作者:Shi,Jin; Stover,James S.; Whitby,Landon R.; Vogt,Peter K.; Boger,Dale L.
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2009 卷标:19(21) 页码:6038-6041]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Methanol; 0 °C; 20 Min,0 °C; 3 H,Rt1.2 Reagents: Potassium Carbonate; 1 H,Rt
  标题:Discovery Of The Parp (Poly Adp-Ribose Polymerase) Inhibitor 2-(1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl)-1H-Benzo[d]Imidazole-4-Carboxamide For The Treatment Of Cancer
  作者:Tang,Lin; Wu,Weibin; Zhang,Cunlong; Shi,Zhichao; Chen,Dawei; Et Al
  参考文献:Bioorganic Chemistry 日期:2021 卷标:114]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 0 °C; 20 Min,0 °C; 3 H,Rt1.2 Reagents: Potassium Carbonate; 1 H,Rt
  标题:Fluorine-Containing Substituted Benzimidazole Derivatives And Their Application In Preparing Drugs For Prevention And Treatment Of Parp (Poly (Adp-Ribose) Polymerase)-Related Diseases
  参考文献:World Intellectual Property Organization]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 60 Min,0 °C; 1.5 H,0 °C; 3 H,10 - 15 °C1.2 Reagents: Potassium Carbonate; Overnight,10 - 15 °C; 15 Min,Rt
  标题:Bronsted Acid Or Lewis Acid Catalyzed [3+3] Cycloaddition Of Azomethine Imines With N-Benzyl Azomethine Ylide: A Facile Access To Bicyclic N-Heterocycles
  作者:Li,Shuo-Ning; Yu,Bin; Liu,Jia; Li,Hong-Lian; Na,Risong
  参考文献:Synlett 日期:2016 卷标:27(2) 页码:282-286]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 0.5 H,0 °C; 0 °C -> Rt; 3 H,Rt1.2 Reagents: Potassium Carbonate; 1 H,Rt
  标题:Discovery Of 2-(1-(3-(4-Chloroxyphenyl)-3-Oxo- Propyl)Pyrrolidine-3-Yl)-1H-Benzo[d]Imidazole-4-Carboxamide: A Potent Poly(Adp-Ribose) Polymerase (Parp) Inhibitor For Treatment Of Cancer
  作者:Min,Rui; Wu,Weibin; Wang,Mingzhong; Tang,Lin; Chen,Dawei; Et Al
  参考文献:Molecules 日期:2019 卷标:24(10)]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Water; 10 Min,0 °C; 2 H,0 °C1.2 Reagents: Potassium Carbonate; 30 Min,0 °C
  标题:Stereo-,Regio-,And Chemoselective [3 + 2]-Cycloaddition Of (2E,4E)-Ethyl 5-(Phenylsulfonyl)Penta-2,4-Dienoate With Various Azomethine Ylides,Nitrones,And Nitrile Oxides: Synthesis Of Pyrrolidine,Isoxazolidine,And Isoxazoline Derivatives And A Computational Study
  作者:Sankar,Ulaganathan; Surya Kumar,Ch. Venkata; Subramanian,V.; Balasubramanian,K. K.; Mahalakshimi,S.
  参考文献:Journal Of Organic Chemistry 日期:2016 卷标:81(6) 页码:2340-2354]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Solvents: Methanol,Water; 0.5 H,0 °C; 1 H,0 °C; 3 H,10 - 15 °C1.2 Reagents: Potassium Carbonate; 2 H
  标题:Process For Preparation Of Chiral 4-(Hydroxymethyl)Pyrrolidin-3-Ols
  参考文献:United States]
  
  53215-95-5 = 93102-05-7 [标题:Reaction Conditions
  标题:Chemistry Of Organosilicon Compounds. 195. N-(Trimethylsilylmethyl)Aminomethyl Ethers As Azomethine Ylide Synthons. A New And Convenient Access To Pyrrolidine Derivatives
  作者:Hosomi,Akira; Sakata,Yasuyuki; Sakurai,Hideki
  参考文献:Chemistry Letters 日期:1984 卷标:(7) 页码:1117-20]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Rt -> 0 °C; 10 Min,0 °C1.2 Reagents: Potassium Carbonate Solvents: Methanol; 0 °C; 1 H,0 °C; 72 H,Rt
  标题:Preparation Of 1,2,3,3A,8,8A-Hexahydro-2,7A-Diazacyclopenta[a]Inden-7-Ones And Related Compounds As Nicotinic Acetylcholine Receptor Ligands Useful In Modulating Cholinergic Function And In The Treatment Of Addictive Disorders
  参考文献:World Intellectual Property Organization]
  
  53215-95-5 = 93102-05-7
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Water; 16 H,0 - 25 °C
  标题:Design,Synthesis,And Validation Of A β-Turn Mimetic Library Targeting Protein-Protein And Peptide-Receptor Interactions
  作者:Whitby,Landon R.; Ando,Yoshio; Setola,Vincent; Vogt,Peter K.; Roth,Bryan L.; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2011 卷标:133(26) 页码:10184-10194

海关参考信息

• 2902300000-甲苯
  2909199090-其他醚及其衍生物
  2921199090-其他无环单胺
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