CAS: 18598-74-8; H-Ile-Ome.Hcl

相似化合物

2577-46-0 148383-11-3 17901-01-8

上下游产品

CAS号67-56-1 甲醇 | CAS号73-32-5 L-异亮氨酸 | CAS号17901-01-8 B°C-异亮氨酸甲酯 | CAS号75-36-5 乙酰氯 | CAS号42807-91-0 N-benzyloxycarb... | CAS号17694-98-3 L-异亮氨酸盐酸盐 | CAS号2387-23-7 N,N’-二环己基脲 | CAS号102342-09-6 (tert-butoxycar... | CAS号17901-01-8 B°C-异亮氨酸甲酯 | CAS号72156-60-6 L-Isoleucine,N-... | CAS号610-88-8 细交链孢菌酮酸

N-Benzyloxycarbonyl-L-Isoleucine Methyl Ester置于盐酸,氢气,溶剂黄146体系中,用 水 用作溶剂,化学反应生成L-异亮氨酸甲酯盐酸盐
参考文献:Hydantoin-Free Synthesis Of Peptide Ester Isocyanates,Isothiocyanates,And Dipeptidyl Ureas: The Application Of Zinc Dust In A Carbonylation Procedure Without Base
标题:Hydantoin-Free Synthesis Of Peptide Ester Isocyanates,Isothiocyanates,And Dipeptidyl Ureas: The Application Of Zinc Dust In A Carbonylation Procedure Without Base
摘要:在使用活性锌粉作为非碱性hcl清除剂的情况下,描述了无需使用海因(hydantoin)的肽酯异氰酸酯自由合成方法,即非schotten-Baumann条件.此外,在将氨基酸和肽酰胺转化为异氰酸酯的过程中,该方法不会产生n-酰化产物.
Doi:10.1055/s-0030-1260216

专利信息

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-10266503-B1
优先权日:2016-05-24
标 题 :Sulfoxide ligand metal catalyzed oxidation of olefins
发明人：WHITE M CHRISTINA; AMMANN STEPHEN E; LIU WEI; MA RULIN
权利人:UNIV ILLINOIS
摘要:The enantioselective synthesis of isochroman motifs has been accomplished via Pd(II)-catalyzed allylic C—H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C—H oxidation reaction proceeds with the broadest scope and highest levels asymmetric induction reported to date (avg. 92% ee, 13 examples ≥90% ee). Additionally, C(sp 3 )-N fragment coupling reaction between abundant terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/sulfoxide (SOX) catalyzed intermolecular allylic C—H amination is disclosed. A range of 52 allylic amines are furnished in good yields (avg. 76%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). For the first time, a variety of singly activated aromatic and aliphatic nitrogen nucleophiles, including ones with stereochemical elements, can be used in fragment coupling stiochiometries for intermolecular C—H amination reactions.

专利号:US-6495693-B2
优先权日:1996-11-22
标题:N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; FOLMER BEVERLY K; JOHN VARGHESE; LATIMER LEE H; NISSEN JEFFREY S; PORTER WARREN J; THORSETT EUGENE D; WU JING
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2022372022-A1
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics

专利号:US-10919882-B2
优先权日:2019-05-09
标题:Compounds for use in synthesis of peptidomimetics

专利号:US-3891692-A
优先权日:1972-05-03
标题:N-(cyclopropylalkoxycarbonyl)amino acids
发明人：VEBER DANIEL F; BRADY STEPHEN F
权利人:MERCK & CO INC
摘要:Novel N-protected- Alpha -amino acid compounds are disclosed in which the amino functionality is protected by a cyclopropylmethoxycarbonyl or 1-cyclopropyl-ethoxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.