CAS: 251647-55-9; (2R,3R,4R,5R)-2-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-5-(2-Isobutyramido-6-Oxo-1,6-Dihydro-9H-Purin-9-yl)-4-(2-Methoxyethoxy)Tetrahydrofuran-3-Yl (2-Cyanoethyl) Diisopropylphosphoramidite

上下游产品

5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-O-(2-甲氧基乙基)-N-(2-甲基-1-氧代丙基)鸟苷 5'-O-(4,4'-Dimethoxytriphenylmethyl)-2'-O-(2-Methoxyethyl)-N2-Isobutyrylguanosine 251647-50-4

双(二异丙基氨基)(2-氰基乙氧基)膦,5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-O-(2-甲氧基乙基)-N-(2-甲基-1-氧代丙基)鸟苷置于n-甲基咪唑,四氮唑体系中,用 Dmf (N,N-Dimethyl-Formamide) 用作溶剂,化学反应 5.0H,以91%的收率获得5'-O-[二(4-甲氧基苯基)苯基甲基]-2'-O-(2-甲氧基乙基)-N-(2-甲基-1-氧代丙基)鸟苷3'-[2-氰基乙基二异丙基氨基亚磷酸酯]
参考文献:Antisense Modulation Of Profilin 1 Expression
标题:Antisense Modulation Of Profilin 1 Expression
摘要:提供了用于调节profilin 1表达的反义物质,组合物和方法.这些组合物包括针对编码profilin 1的核酸的反义物质,特别是反义寡核苷酸.提供了利用这些化合物调节profilin 1表达以及治疗与profilin 1表达相关疾病的方法.

专利信息

专利号:WO-2025082632-A1
优先权日:2023-10-16
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU
权利人:BACHEM HOLDING AG
摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.

专利号:EP-4605403-A1
优先权日:2022-10-17
标 题:Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.

专利号:WO-2024083746-A1
优先权日:2022-10-17
标 题 :Method and composition for oligonucleotide synthesis
发明人：SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL
权利人:BACHEM HOLDING AG
摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.