CAS: 2567-29-5; 4-(Bromomethyl)-1,1'-Biphenyl

上下游产品

CAS号3597-91-9 4-联苯甲醇 | CAS号589-15-1 对溴溴苄 | CAS号98-80-6 苯硼酸 | CAS号644-08-6 4-甲基联苯 | CAS号16004-15-2 对碘溴苄 | CAS号768-59-2 4-乙基苄醇 | CAS号92-92-2 4-苯基苯甲酸 | CAS号108-86-1 溴苯 | CAS号5720-05-8 对甲基苯基硼酸 | CAS号4748-78-1 4-乙基苯甲醛 | CAS号1432-30-0 2-[2-(4-phenylp... | CAS号21326-80-7 1,2-二([1,1'-联苯]... | CAS号92-92-2 4-苯基苯甲酸 | CAS号2920-38-9 4-氰基联苯 | CAS号3218-36-8 4-联苯甲醛 | CAS号644-08-6 4-甲基联苯 | CAS号31603-77-7 4-联苯乙腈 | CAS号63024-23-7 Dl-3-(4-联苯)丙氨酸盐酸盐 | CAS号69605-90-9 3-联苯甲醇 | CAS号76985-08-5 2-氨基-3-(4-联苯基)丙酸

4-苯基苯甲酸置于n-溴代丁二酰亚胺(Nbs),Lithium Aluminium Tetrahydride,硫酸,三苯基膦体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4-溴甲基联苯
参考文献:钴催化末端炔烃的 1,1,3-三甲基化
标题:钴催化末端炔烃的 1,1,3-三甲基化
摘要:我们开发了一种钴催化的末端炔烃与频哪醇硼烷 (Hbpin) 的区域选择性 1,1,3-三苯甲基化反应,催化剂由容易获得且工作稳定的 Co(Acac) 2原位生成和黄磷.多种末端炔烃经历此三苯甲基化反应,以高收率和高选择性提供相应的 1,1,3-三硼烷基烷烃.该催化协议的合成效用已通过开发 1,1,3-三苯烷基烷产品的选择性逐步功能化得到证明.进行对照实验和氘标记反应,监测反应过程和识别反应中间体等机理研究的结果表明,这种 1,1,3-三硼化反应通过 Alken-1-的 1,3-二硼化进行的.由钴催化的末端炔烃的硼氢化形成的基硼酸盐.
Doi:10.1021/acs.Organomet.2C00053

专利信息

专利号:US-8710261-B2
优先权日:2005-02-22
标 题:5-phenyl-pentanoic acid derivatives as matrix metalloproteinase inhibitors for the treatment of asthma and other diseases
发明人：PALLE VENKATA P; SATTIGERI VISWAJANANI JITENDRA; KHERA MANOJ KUMAR; VOLETI SREEDHARA RAO; RAY ABHIJIT; DASTIDAR SUNANDA G
权利人:PALLE VENKATA P; SATTIGERI VISWAJANANI JITENDRA; KHERA MANOJ KUMAR; VOLETI SREEDHARA RAO; RAY ABHIJIT; DASTIDAR SUNANDA G; RANBAXY LAB LTD
摘要:The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R 1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R 2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR 4 R 5 , —NHC(â•?Y)R 4 , —NHC(â•?Y)NR 5 R χ , —NHC(â•?O)OR 4 , —NHSO 2 R 4 , C(â•?Y)NR 4 R 5 , C(â•?O)OR 6 [wherein Y is oxygen or sulphur], OR 5 , —O(Câ•?O)NR 4 R 5 , O-acyl, S(O) m R 4 , —SO 2 N(R 4 ) 2 , cyano, amidino or guanidino [wherein R 4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R 5 is hydrogen or R 4 ; R x is R 4 or —SO 2 N(R 4 ) 2 and R 6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R 3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR 4 , —OC(â•?O)NR 4 R 5 , O-acyl, NH 2 , NR 4 R 5 , —NHC(â•?Y)R 4 , —NHC(â•?Y)NR 5 R x , —NHC(â•?O)OR 4 , —NHSO 2 R 4 , and to processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterize by over-expression and over-activation of an matrix metalloproteinase, using the compounds.

专利号:US-5932743-A
优先权日:1997-08-21
标 题:Methods for the solid phase synthesis of substituted indole compounds
发明人：COLLINI MICHAEL D; ELLINGBOE JOHN W
权利人:AMERICAN HOME PROD
摘要:The present invention relates to novel substituted indole compounds of formula (I) having pharmacological activity, to processes for their preparation, to solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-2020181095-A1
优先权日:2017-06-06
标题:Selective matrix metalloproteinase-13 inhibitors
发明人：FIELDS GREGG B; ROUSH WILLIAM R; CHOI JUN YONG; FUERST RITA
权利人:FLORIDA ATLANTIC UNIV BOARD OF TRUSTEES; SCRIPPS RESEARCH INST
摘要:We describe the use of comparative structural analysis and structure-guided molecular design to develop potent and selective inhibitors (10d and (S)-17b) of matrix metalloproteinase 13 (MMP-13). We applied a three-step process, starting with a comparative analysis of the X-ray crystallographic structure of compound 5 in complex with MMP-13 with published structures of known MMP-13 inhibitor complexes followed by molecular design and synthesis of potent, but non-selective zinc-chelating MMP inhibitors (e.g., 10a and 10b). After demonstrating that the pharmacophores of the chelating inhibitors (S)-10a, (R)-10a, and 10b were binding within the MMP-13 active site, the Zn2+ chelating unit was replaced with non-chelating polar residues that bridged over the Zn2+ binding site and reach into a solvent accessible area. After two rounds of structural optimization, these design approaches led to small molecule MMP-13 inhibitors 10d and (S)-17b which bind within the substrate-binding site of MMP-13 and surround the catalytically active Zn2+ ion without chelating to the metal. These compounds exhibit at least 500-fold selectivity versus other MMPs.

专利号:WO-9909007-A1
优先权日:1997-08-21
标题:Solid phase synthesis of 2,3-disubstituted indole compounds
发明人：COLLINI MICHAEL DAVID; ELLINGBOE JOHN WATSON
权利人:AMERICAN HOME PROD
摘要:The present invention relates to novel substituted indole compounds of formula (I) having pharmacological activity, to processes for their preparation, to a combinatorial library and solid phase methods for preparing libraries of the compounds, to utilizing libraries of the compounds for drug discovery, and to pharmaceutical compositions thereof.

专利号:US-5693720-A
优先权日:1994-03-22
标 题:Solid-phase synthesis utilizing photochemical carbon-sulfur bond cleavage of thioethers
发明人：SUCHOLEIKI IRVING
权利人:LILLY CO ELI
摘要:A method for photochemical cleavage of carbon-sulfur bonds in conjunction with solid-phase synthesis utilizing a deoxygenated solvent and light to cleave the carbon-sulfur bond from a heterogeneous support. Also disclosed are compounds for use with said photochemical cleavage and methods of preparing them.

专利号:US-11767302-B2
优先权日:2020-10-01
标题 :Reagents and methods for tetrazine synthesis
发明人：FOX JOSEPH M; LAMBERT WILLIAM; FANG YINZHI; AM ENDE CHRISTOPHER WILLIAM; MAHAPATRA SUBHAM; XIE YIXIN; WANG CHUANQI
权利人:UNIV DELAWARE
摘要:Disclosed herein are mono- and di-substituted tetrazines and methods of their preparation and converting an oxetanyl ester to a thio-substituted tetrazine, which is then converted to a mono-substituted tetrazine, a di-substituted tetrazine, or a vinylether disubstituted tetrazine.