专利号:US-2024026314-A1 优先权日:2020-11-25 标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds 发明人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN 摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.
专利号:US-7253324-B1 优先权日:2007-01-23 标 题:Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers 发明人:MAJEED MUHAMMED; THOMAS SAMUEL MANOHARAN; NAGABHUSHANAM KALYANAM; BALAKRISHNAN SIVAPRAKASH KURUM; PRAKASH SUBBALAKSHMI 权利人:SAMI LABS LTD 摘要:Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.
专利号:US-10125119-B2 优先权日:2017-03-22 标 题:Series of resveratrol-derivative fluorescently labeled molecules and synthesis method thereof 发明人:XU WEIMING; ZHANG PENGFEI; LI WANMEI; DU KUI; Chai kejie 权利人:UNIV HANGZHOU NORMAL 摘要:The invention discloses a series of resveratrol-derivative fluorescently labeled molecules and a synthesis method thereof. The fluorescently labeled molecules has a molecular formula as shown in formula (I). The synthesis method includes the steps of adding a certain amount of resveratrol derivative and solvent in a reaction vessel, adding a fluorescent marker as shown in formula (III) and a certain amount of alkali, reacting at 20° C.-60° C. for 2-10 hours, and after the reaction is completed, spin-drying the reaction solvent and performing post-processing to obtain the products.
专利号:US-6147121-A 优先权日:1998-04-10 标题 :Skin toning by stimulating collagen synthesis/proliferation of dermal fibroblasts 发明人:BRETON LIONEL; LIVIERO CHRISTEL; FAGOT DOMINIQUE 权利人:OREAL 摘要:The hydroxystilbenes are effective collagen-synthesizing, and/or fibroblast-proliferating, and/or protease expression-inhibiting, and/or skin aging-combating, and/or flaccid/wrinkled skin-treating, and/or skin-smoothing/firming, and/or menopausal cutaneous effect-treating, and/or menopausal collagen/fibroblast effects-treating active agents, for topical application onto the skin and/or mucous membranes of a human subject in need of such treatment(s).
专利号:WO-2008091379-A1 优先权日:2007-01-23 标题 :A process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkyllethers
专利号:EP-4251758-A1 优先权日:2020-11-25 标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds
参考文献:10.1016/j.bmcl.2015.09.064 摘要:Sheng JY, Chen TT, Tan XJ, Chen T, Jia AQ. The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5217–20. doi: 10.1016/j.bmcl.2015.09.064. 参考文献:10.1016/j.bmcl.2006.08.018 摘要:Likhitwitayawuid K, Sornsute A, Sritularak B, Ploypradith P. Chemical transformations of oxyresveratrol (trans-2,4,3′,5′-tetrahydroxystilbene) into a potent tyrosinase inhibitor and a strong cytotoxic agent. Bioorganic & Medicinal Chemistry Letters. 2006 Nov;16(21):5650–3. doi: 10.1016/j.bmcl.2006.08.018.