CAS: 32233-40-2; (3Ar,4S,5R,6As)-5-Hydroxy-4-(Hydroxymethyl)Hexahydro-2H-Cyclopenta[b]Furan-2-One

上下游产品

CAS号39746-00-4 科里内酯 | CAS号62939-82-6 ((3aR,4S,6aS)-5... | CAS号58707-50-9 (3aR,4S,5R,6aS)... | CAS号57930-46-8 (3AR,4S,5R,6AS)... | CAS号26054-65-9 [(3aR,4S,5R,6aS... | CAS号109122-52-3 (4aS,4bR,7aS,8a... | CAS号31752-99-5 (-)-科里内酯4-苯基苯甲酸醇 | CAS号333963-40-9 鲁比前列酮 | CAS号54276-21-0 氯前列醇 | CAS号41639-83-2 拉坦前列腺素(游离酸) | CAS号352276-28-9 拉坦前列腺素内半缩醛 | CAS号130209-82-4 拉坦前列素 | CAS号65025-95-8 (3aR,4S,5R,6aS)... | CAS号60325-46-4 硫前列酮 | CAS号551-11-1 地诺前列素 | CAS号101208-17-7 (-)-3-羰基-6-Β -三... | CAS号136790-76-6 鲁比前列素

7,7-二氯二环[3.2.0]庚-2-烯-6-酮置于甲酸,硫酸,(S)-6,6'-Bis(2,4,6-Triisopropylphenyl)-1,1'-Spirobiindane-7,7'-Diyl Hydrogenphosphate,双氧水,氯化铵,锌体系中,用 甲醇,氯仿,水 作为反应溶剂,化学反应 77.0H,反应生成 科立内脂二醇
参考文献:通过立体控制的有机催化拜耳-维利格氧化法获得前列腺素家族的重要组成部分
标题:通过立体控制的有机催化拜耳-维利格氧化法获得前列腺素家族的重要组成部分
摘要:开发了一种新的协议,该协议使用立体控制的有机催化baeyer-Villiger(b-V)氧化来构建前列腺素的关键双环内酯.用过氧化氢水溶液对外消旋环丁酮衍生物进行关键的b-V氧化,可以早期构建对映体过量(最高95%)的双环内酯骨架.产生的双环内酯完全充满两个所需的立体中心,并能够根据corey的路线合成整个前列腺素家族.此外,还评估了外消旋双环环丁酮的b-V氧化反应的反应性和对映选择性,且ee值为90-99%获得了代表手性内酯的最有效途径之一.这项研究进一步促进了前列腺素和手性内酯天然产物的合成,从而促进了药物的发现.
DOI:10.1002/anie.201902371

专利信息

专利号:US-8309744-B2
优先权日:2008-08-29
标题:Prostaglandin synthesis and intermediates for use therein
发明人：ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN
权利人:ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN; ALPHORA RES INC
摘要:Fused cyclopentane—4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: n nwherein R represents an aryl group such as p-methoxyphenyl.n n This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required α-side chain and then the required ω-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.

专利号:US-8513441-B2
优先权日:2008-08-29
标题:Prostaglandin synthesis and intermediates for use therein
发明人：ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN
权利人:ALBERICO DINO; CLAYTON JOSHUA; GORIN BORIS IVANOVICH; OUDENES JAN; ALPHORA RES INC
摘要:Fused cyclopentane-4-substituted 3,5-dioxalane lactone compounds useful as an intermediate in the synthesis of prostaglandin analogs are provided. The compounds have the formula A: n nwherein R represents an aryl group such as p-methoxyphenyl.n n This compound can be reacted with a lower alkyl aluminum compound to open the dioxalane ring and reduce the lactone to lactol, without over-reducing to diol. The resulting compound can be functionalized to insert chemical side groups of target prostaglandins, adding the required α-side chain and then the required ω-side chain sequentially and independently of each other. The compounds and process are particularly suitable for preparing lubiprostone.

专利号:EP-2495235-A1
优先权日:2011-03-04
标 题 :Process for the synthesis of prostaglandins and intermediates thereof

专利号:EP-2495235-B1
优先权日:2011-03-04
标 题:Process for the synthesis of prostaglandins and intermediates thereof
发明人：MARIANI EDOARDO; ORRU GIANMAURO; MONTORSI MAURO; ANDRIOLO ERIKA; BANDINI MARCO; CONTENTO MICHELE; TOLOMELLI ALESSANDRA
权利人:NEWCHEM S P A

专利号:SI-2576565-T1
优先权日:2010-05-31
标 题 :Synthesis of carbanucleoside and its new useful intermediates