CAS: 39545-31-8; 2-Chlorobenzyl Carbonochloridate

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CAS号500372-17-8 O-(2-chlorobenz... | CAS号75-44-5 光气 | CAS号17849-38-6 2-氯苄醇 | CAS号42390-97-6 N6-(((2-氯苯基)甲氧基...

邻氯苄醇置于磺酰氯,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 四氢呋喃 用作溶剂,20.0 °C,100.0 Kpa 条件下,反应 18.0H,反应生成2-氯苯基氯甲酸酯
参考文献:氯甲酸苄酯(cbzcl)的非光气合成
标题:氯甲酸苄酯(cbzcl)的非光气合成
摘要:建立了以一氧化碳或羰基硫为羰基来源的氯甲酸苄酯(cbzcl)合成方法.S-甲基o-苄基硫代碳酸盐的硫酰氯氯化法成功地合成了氯甲酸苄酯,其是通过在dbu(1,8-二氮杂双环)存在下,将苄醇与一氧化碳和硫(或羰基硫)进行羰基化反应制得的. [5.4.0]十一碳-7-烯),然后使用甲基碘进行酯化.
Doi:10.1016/s0040-4039(02)01834-8

专利信息

专利号:WO-2006046949-A1
优先权日:2004-10-22
标 题 :SYNTHESIS AND ANTIMALARIAL ACTIVITY OF PYRROLO[3,2-f]QUINAZOLINE-1,3- DIAMINE DERIVATIVES
发明人：AI J LIN; JIAN GUAN; QUAN ZHANG; SKILLMAN DONALD R
权利人:WALTER REED ARMY INST OF RES W; AI J LIN; JIAN GUAN; QUAN ZHANG; SKILLMAN DONALD R
摘要:The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P.vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs,. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

专利号:US-7253177-B2
优先权日:2004-10-22
标 题:Synthesis and antimalarial activity of pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives
发明人：LIN AI J; GUAN JIAN; ZHANG QUAN; SKILLMAN DONALD R
权利人:US ARMY
摘要:The invention relates to derivatives of pyrroloquinazolinediamine, more specifically derivatives of 7-(substituted)-7H-pyrrolo[3,2-F] quinazoline-1,3-diamines that are non-toxic and are also effective in the treatment of malaria, including P. falciparum and P. vivax strains. The derivatives are certain carbamate derivatives, succinimide derivatives, alkylcarboxamides derivatives and acetamide derivative, phthalimides, alkylamines and all other amide and imide derivatives and their 1-hydroxy analogs. The derivatives of the present invention are also soluble in common organic solvents to facilitate the purification in a large scale synthesis of the composition.

专利号:US-8673885-B1
优先权日:2010-07-25
标 题 :Compounds for the protection of sulfur containing linkers in nucleic acid synthesis
发明人：DUFF ROBERT
权利人:DUFF ROBERT
摘要:Aromatic and alkyl thiocarbonates with and without a neighboring group that participates in the hydrolysis of a thiocarbonate are described. The aromatic or alkyl thiocarbonates can be used for the protection of sulfur during oligonucleotide synthesis. Their facile processes of manufacture and methods of using the same are provided.

专利号:US-2006094736-A1
优先权日:2004-10-22
标题:Synthesis and antimalarial activity of pyrrolo[3,2-f]quinazoline-1,3-diamine derivatives