2-甲基-4-甲氧基苯胺置于sodium Hydroxide,Potassium Permanganate体系中,化学反应生成 4-甲氧基-2-甲基苯甲酸 参考文献:Ortho Substitution Rearrangement Of Certain 3-Substituted And 3,5-Disubstituted Benzyltrimethylammonium Ions By Sodium Amide1 标题:Ortho Substitution Rearrangement Of Certain 3-Substituted And 3,5-Disubstituted Benzyltrimethylammonium Ions By Sodium Amide1 摘要: DOI:10.1021/jo01351A039
专利号:WO-2025019598-A1 优先权日:2023-07-20 标 题:Positive allosteric modulator of the metabotropic glutamate receptor subtype 2 receptor, synthesis and solid forms thereof 发明人:COSFORD NICHOLAS DAVID PETER; SHEFFLER DOUGLAS J 权利人:SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INST 摘要:Described herein are solid forms of sodium 4-chloro-3'-(((2-cyclopentyl-1-oxoisoindolin-5-yl)oxy)methyl)-[1,1'-biphenyl]-3-carboxylate and its pharmaceutical composition for the treatment of disease.
专利号:RU-2585623-C1 优先权日:2014-11-20 标题 :METHOD FOR SYNTHESIS OF 7-METHOXY-4-NITRO-3-(p-METHOXYPHENYL) ISOQUINOLINONE DERIVATIVES
专利号:WO-9314086-A1 优先权日:1992-01-17 标 题 :Substituted 1-isoquinolone derivatives as angiotensin ii antagonists 发明人:FISHER LAWRENCE E; CAROON JOAN M; STABLER STEPHEN R; CLARK ROBIN D 权利人:SYNTEX INC 摘要:1-Isoquinolone derivatives and related compounds according to formula (I) wherein, Y is selected from the group consisting of H, OH, lower alkoxy, and halo; X is selected from the group consisting of H, lower alkyl acid, lower alkyl ester, and lower alkyl; and R1 is selected from the group consisting of H, alkenyl, lower alkyl, lower cycloalkyl, unsubstituted or substituted 3-spiro-1H-indane of structure (II) wherein R2 is H, OH, lower alkyl, lower alkoxy or halo, and 3-spiro-cycloalkyl of structure (III) wherein n is an integer from zero to six, provided that when R1 is spiro- X is H, or a pharmaceutically acceptable salt thereof, with the proviso that when R1 is spiro-, X is H, and when R1 is H, alkenyl, lower alkyl or lower cycloalkyl substituted at the 3-position of the isoquinolone moiety and X is H or lower alkyl, the (2'-1H--tetrazol-5-yl)biphenyl-4'-ylmethyl group cannot be at the 2(N) position, are useful as angiotensin II receptor antagonists. Also disclosed are methods of synthesis, intermediates, pharmaceutical formulations and methods of treatment.
专利号:CN-109053542-A 优先权日:2018-07-25 标题:A kind of chemical synthesis method of 6-bromo-5-hydroxyisoindoline-1-one
专利号:US-8461107-B2 优先权日:2008-04-28 标题:HCV NS3 protease inhibitors 发明人:LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; GILBERT KEVIN F; MCINTYRE CHARLES J; RUDD MICHAEL T 权利人:LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; GILBERT KEVIN F; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME 摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.
专利号:WO-2010099503-A1 优先权日:2009-02-26 标题:Compositions, synthesis, and methods of utilizing quinazolinedione derivatives
[参考文献]: A Omodei-Salé, Et Al. A New Class Of Nonhormonal Pregnancy-Terminating Agents. Synthesis And Contragestational Activity Of 3,5-Diaryl-S-Triazoles. J Med Chem. 1983 Aug;26(8):1187-92.
合成参考文献
摘要:Zhang, M.; Su, W., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 113. 摘要:D. Peltier, C. R. Acad. Sci., Ser. C 241, 1467 (1955). 摘要:Arun, V.; Saha, S. K.; De Sarkar, S., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 365.