CAS: 63149-33-7; 8-Hydroxy-1,2,3,5,6,7-Hexahydropyrido[3,2,1-Ij]Quinoline-9-Carbaldehyde

该化合物是一种有机化合物,其独特的结构特征包括一个氢氧基组和一个附属于酸盐框架的甲酰胺功能组,该化合物一般是固体的,因其在有机合成和荧光的吸收和发光能力而具有潜在用途而为人所知,作为荧光探针.氢氧基组的存在有助于其再活动,允许其参与各种化学反应,如凝聚和氧化.此外,甲酰胺组可以进行核分裂性添加反应,使其成为合成更复杂的分子的多功能中间体.其化学特性,包括溶性与稳定性,视溶剂和环境条件而不同.与许多有机化合物一样,在处理8-Hydroxyjulolidine-9-carboxalhydede时,应当采取安全防范措施,因为如果浸泡或吸入,可能会对健康造成风险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号41175-50-2 8-羟基久洛里定 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号63468-83-7 8-甲氧基久洛利定 | CAS号536-90-3 间氨基苯甲醚 | CAS号591-27-5 间氨基苯酚 | CAS号55804-65-4 香豆素 343 | CAS号55804-67-6 10-乙酰基-2,3,6,7-... | CAS号58336-35-9 香豆素 6H

合成工艺路线路线简述

    间氨基苯甲醚置于盐酸,氢碘酸,Sodium Carbonate,三氯氧磷体系中,用 水 作为反应溶剂,化学反应 16.75H,反应生成 8-羟基久洛尼定-9-甲醛
    参考文献:Novel Iminocoumarin Derivatives: Synthesis,Spectroscopic And Computational Studies
    标题:Novel Iminocoumarin Derivatives: Synthesis,Spectroscopic And Computational Studies
    摘要:从3-苯并咪唑取代香豆素和不同芳香醛合成了三种具有高量子产率的新型亚氨基香豆素衍生物.通过uv-可见光谱和荧光光谱在极性和非极性溶剂中研究了合成化合物的光物理行为.这些化合物在450Nm左右显示最大吸收峰,在500Nm左右显示最大发射峰.这些化合物在二氯甲烷和氯仿中的量子产率大于0.90.化合物的吸收,发射和量子产率依赖于溶剂极性.除了强烈的吸收外,这些化合物在研究的溶剂中还显示肩峰吸收.溶剂极性图揭示了合成分子中从给体到受体的电荷转移过程.密度泛函理论和含时密度泛函理论计算被用来更好地理解染料的结构,分子,电子和光物理参数.通过ft-Ir,1H NMR,13C NMR和质谱分析对染料进行了表征.
    DOI:10.1007/s10895-015-1648-4

    海关参考信息

    专利信息


    专利号:WO-2021176428-A1
    优先权日:2020-03-06
    标 题 :Phenanthroline, carbazole and flavylium based cyanines and compositions and methods of making and using the same
    发明人:THIMMAIAH GOVINDARAJU; VENKATA SUSEELA YELISETTY; SATHA PARDHASARADHI
    权利人:JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENT RESEARCH
    摘要:The present disclosure is in the field of pharmaceutical and chemical sciences, including the synthesis of theranostic agents and processes for preparing such agents. In particular, the disclosure relates to important phenanthroline, carbazole and flavylium based cyanine group containing chemical compounds, method of preparing such molecules and compositions thereof, and the use of such molecules and compositions as a probe and diagnostic agent in the diagnosis and treatment of diseases including cancer.

    专利号:US-11034677-B2
    优先权日:2015-01-20
    标 题:Coumarin-based compounds and related methods
    发明人:SANCHEZ ANTHONY DE JESUS
    权利人:BIOSEARCH TECH INC
    摘要:The present invention generally relates to coumarin-based compounds that can be used for the labeling of biological molecules, as well as related synthetic and testing methods. The coumarin-based compounds typically survive conditions necessary for automated synthesis of nucleic acids without undergoing any substantial degree of degradation or alteration.

    专利号:US-6417195-B1
    优先权日:1999-02-22
    标题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAL
    权利人:LION BIOSCIENCE AG
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compounds.

    专利号:US-5874443-A
    优先权日:1995-10-19
    标 题:Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:KIELY JOHN S; GRIFFITH MICHAEL C
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinolines as well as novel libraries comprised of many such compounds, and methods of synthesizing the libraries.

    专利号:WO-0050406-A1
    优先权日:1999-02-22
    标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries
    发明人:LEBL MICHAEL
    权利人:TREGA BIOSCIENCES INC
    摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.

    专利号:CN-114671893-A
    优先权日:2021-11-16
    标 题 :A kind of iron ion probe based on open-closed loop and its synthesis method
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    合成参考文献


    参考文献:10.1007/s10895-011-0919-y
    摘要:Shanker N, Dilek O, Mukherjee K, McGee DW, Bane SL. Aurones: Small Molecule Visible Range Fluorescent Probes Suitable for Biomacromolecules. Journal of Fluorescence. 2011 Jul 12;21(6):2173. doi: 10.1007/s10895-011-0919-y.
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