CAS: 632-16-6; 2,3-Dimethylthiophene

该化合物是一种杂交有机化合物,其特点是五人环,含有硫磺和碳原子,其特征为2和3位置的硫苯环上的两个甲基组,影响其化学特性和活性.该化合物一般没有颜色可粉黄,具有独特的气味,与含硫化合物有相似的味道,与含硫化合物有相似之处,在乙醇和乙醚等有机溶剂中溶解,但水溶性有限.2,3-二甲基硫苯因其在有机合成中的作用和在生产各种化学品(包括制药和农用化学品)中的中间作用而著称.它存在于某些天然产品中,及其在材料科学中的潜在应用,特别是在发展导电聚合物方面,引起了对学术和工业研究的兴趣.此外,与许多硫苯衍生物一样,它也表现出有趣的电子特性,可在电子设备中加以利用.在处理这一化合物时应采取安全防范措施,因为接触时可能会对健康造成风险.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号5834-16-2 3-甲基-2-噻吩甲醛 | CAS号6153-05-5 (Z)-3-甲基戊-2-烯-4... | CAS号616-44-4 3-甲基噻吩 | CAS号74-88-4 碘甲烷 | CAS号5895-88-5 Hydrazinecarbox... | CAS号6628-79-1 β-甲基乙酰丙酸 | CAS号74-86-2 乙炔 | CAS号14282-76-9 2-溴-3-甲基噻吩 | CAS号554-14-3 2-甲基噻吩 | CAS号40808-24-0 4,5-二甲基噻吩-2-羰酸 | CAS号250609-29-1 2,3-DIMETHYL-5-... | CAS号188290-36-0 Thiophene(SIV) | CAS号872-55-9 2-乙基噻吩 | CAS号638-02-8 2,5-二甲基噻吩 | CAS号616-44-4 3-甲基噻吩 | CAS号632-15-5 3,4-二甲基噻吩 | CAS号638-00-6 2,4-二甲基噻吩 | CAS号554-14-3 2-甲基噻吩 | CAS号108-88-3 甲苯

合成工艺路线路线简述

    3-甲基-4-氧代戊酸置于diphosphorus Trisulfide体系中,化学反应生成 2,3-二甲基噻吩
    参考文献:Meyer,V.,Die Thiophengruppe,S. 39 Anm.
    标题:Meyer,V.,Die Thiophengruppe,S. 39 Anm.

    专利信息


    专利号:US-9802952-B2
    优先权日:2013-07-15
    标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
    发明人:KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
    权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
    摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

    专利号:US-7635781-B2
    优先权日:2001-05-15
    标 题:Synthesis of cyclopentadiene derivatives
    发明人:NIFANT EV ILYA; KASHULIN IGOR; IVCHENKO PAVEL; KLUSENER PETER; KORNDORFFER FRANS; DE KLOE KEES; RIJSEMUS JOS
    权利人:BASELL POLYOLEFINE GMBH
    摘要:A compound of formula (X): n n n n n n n n n n n n wherein n R 1 , R 2 , equal to or different from each other are hydrogen or a linear or branched saturated or unsaturated C 1 -C 20 -alkyl, C 3 -C 20 -cycloalkyl, C 6 -C 20 -aryl, C 7 -C 20 -alkylaryl or C 7 -C 20 -arylalkyl radical, optionally containing heteroatoms belonging to groups 13-17 of the Periodic Table of the Elements; or they can form a C 4 -C 7 ring optionally containing O, S, N, P or Si atoms that can bear substituents; n R 3 is hydrogen or a linear or branched saturated or unsaturated C 1 -C 20 -alkyl, C 3 -C 20 -cycloalkyl, C 6 -C 20 -aryl, C 7 -C 20 -alkylaryl or C 7 -C 20 -arylalkyl radical, optionally containing heteroatoms belonging to groups 13-17 of the Periodic Table of the Elements; or two adjacent R 3 groups can form a C 4 -C 7 ring optionally containing O, S, N, P or Si atoms, wherein said ring can bear substituents; n and at least one of R 1 , R 2 or R 3 is different from hydrogen.

    专利号:US-8258298-B2
    优先权日:2008-12-10
    标 题 :Synthesis of morphine-6-glucuronide or one of the derivatives thereof
    发明人:DLUBALA ALAIN; TRECANT CLAIRE; RIPOCHE ISABELLE
    权利人:DLUBALA ALAIN; TRECANT CLAIRE; RIPOCHE ISABELLE; SANOFI SA
    摘要:The disclosure relates to a method for preparing morphine-6-glucuronide or one of the deritives thereof comprising reacting a compound of formula (I): n nwherein R 1 is as defined in the disclosure,n nwith a glucuronic acid derivative of formula (II):n n nwherein PG, X, and R 4 are as defined in the disclosure,n nin the presence of an aromatic solvent and trimethylsilyl trifluoromethanesulfonate;n n(ii) reacting the product obtained in step (i) with a strong basic agent; and then (iii) recovering the product obtained in step (ii).

    专利号:US-7329767-B2
    优先权日:2003-10-03
    标 题:Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
    发明人:DEWIS MARK L; JOHN THUMPLASSERIL V; ECKERT MARKUS A; COLSTEE JAN HERMAN; DA COSTA NEIL C; PEI TAO
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formulan n nwherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

    专利号:US-8007841-B2
    优先权日:2003-10-03
    标 题 :Conjugated dienamides, methods of production thereof, compositions containing same and uses thereof
    发明人:JOHN THUMPLASSERIL V; ECKERT MARKUS A; DEWIS MARK L; COLSTEE JAN HERMAN; DA COSTA NEIL C
    权利人:INT FLAVORS & FRAGRANCES INC
    摘要:Described are mixtures of at least four of the alkadienamides defined according to the structure: n nwherein R represents C 1 -C 2 n-alkyl; R 1 is 2-methyl-1-propyl and R 2 is hydrogen, or R 1 and R 2 taken together is a moiety having the formula —(CH 2 ) n —, wherein n is 4 or 5, or compositions containing substantial concentrations of such mixtures, prepared according to novel processes: (a) extraction of a ground substantially dried fruit of one of the Piper species, Piper longum Linn or Piper peepuloides ; (b) natural product-forming synthesis; or (c) synthetic product-forming synthesis. Also described are uses of the thus-formed products for augmenting, enhancing or imparting an aroma, taste, chemesthetic effect and/or antibacterial effect in or to a consumable material and/or in the oral cavity and/or on the mammalian epidermis.

    专利号:US-7129361-B2
    优先权日:1998-04-15
    标 题 :Thienylazolylalkoxyethanamines, their preparation and their application as medicaments
    发明人:MERCE-VIDAL RAMON; ANDALUZ-MATARO BLAS; FRIGOLA-CONSTANSA JORDI
    权利人:ESTEVE LABOR DR
    摘要:The thienylazolylalkoxyethanamines (I) where R1 is a hydrogen atom, a halogen atom or a lower alkyl radical; R2, R3 and R4 represent, independently, a hydrogen atom or a lower alkyl radical; and Az represents a five-member nitrogenated hetercyclic aromatic group, N-methyl-substituted, that contains from one to three nitrogen atoms. They have analgesic activity in mammals, including humans. The compounds (I) can be obtained, for example, by reaction of a derivative of hydroxy-thienylazol (IV) with a derivative of a suitable N-(ethyl)amine. The compounds (IV) are useful intermediates in the synthesis of the compounds (I). The compounds (I) have an application in human and/or veterinary medicine.
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    合成参考文献


    摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 367.
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