CAS: 93204-36-5; N-Cbz-D-Serine Methyl Ester

• 英文名称N-Cbz-D-Serine Methyl Ester
• 中文名称N-Z-D-丝氨酸甲酯
• IUPAC名称methyl ((benzyloxy)carbonyl)-D-serinate
• 其它别名N-Carbobenzyloxy-D-Serine Methyl Ester; Z-D-Serine Methyl Ester; Z-D-Ser-Ome; N-Z-D-Serine Methyl Ester; (R)-Z-2-Amino-3-Hydroxypropionic Acid Methyl Ester; Z-D-Serine Methyl Ester≥ (Hplc); Z-D-β-Hydroxyalanine Methyl Ester; Z-D-Ser-0Me
• CAS编号93204-36-5
• MFCD编号:MFCD00799501
• 分子式:C12H15NO5
• 分子量:253.25
• 产品CID: 1970486
• 产品分类生物化工 → 氨基酸及其衍生物 → 丝氨酸类衍生物

• 相似结构搜索
• InChIKey: CINAUOAOVQPWIB-SNVBAGLBSA-N
• InChI=1S/C12H15NO5/c1-17-11(15)10(7-14)13-12(16)18-8-9-5-3-2-4-6-9/h2-6,10,14H,7-8H2,1H3,(H,13,16)/t10-/m1/s1…
• 计算化学: 氢键受体数5.0氢键供体数2.0可旋转键数7.0

物理性质

• 熔点41-43 °C(文献)
• 沸点442.6±45.0 °C at 760 mmHg
• 闪点221.5±28.7 °C
• 密度1.254g/cm3
• pKa:10.49±0.46(预测)
• PSA:88.35
• LogP:1.42
• 折射率1.536
• 蒸汽压0.0±1.1 mmHg at 25°C
• 敏感性稳定 避免接触强氧化剂
• 外观形态白色固体
• 储存条件密封, 常温干燥保存
• 产品应用该化合物是合成四氢硫基辛基氨基烷基醇(如环烷基酰胺)的关键中间体.

MSDS等安全信息

• 警示词Warning
• 危险描述H302-H315-H319-H335-
• 防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338-
• UN编号NONH for all modes of transport
• WGK Germany3

上下游产品

合成工艺路线路线简述

• 5874-57-7 = 93204-36-5
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Tetrahydrofuran,Water
  标题:Stereoisomers Of Monatin,Their Use As Sweeteners,And Preparation Of Of Them And Their Intermediates
  参考文献:Japan]
  
  6081-61-4 = 93204-36-5
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Methanol; 30 - 45 Min,10 - 15 °C; 15 °C -> 30 °C; 10 - 12 H,25 - 30 °C
  标题:Process For The Preparation Of Lacosamide Using A New Intermediate
  参考文献:India]
  
  24184-43-8 = 93204-36-5
  反应条件:1.1 Catalysts: Tetrabutylammonium Bromide; 25 Min,Rt
  标题:A Mild And Efficient Chemoselective N-Benzyloxycarbonylation Of Amines Using Tbab As A Catalyst Under Solvent-Free Conditions
  作者:Babu,Kothamasu Suresh; Rao,Vidadala Rama Subba; Rao,Ravu Ranga; Babu,Sakhamuri Sivaram; Rao,Janaswami Madhusudana
  参考文献:Canadian Journal Of Chemistry 日期:2009 卷标:87(2) 页码:393-396]
  
  6081-61-4 = 93204-36-5
  反应条件:1.1 Reagents: Acetyl Chloride Solvents: Methanol
  标题:A Practical Route To Regiospecifically Substituted (R)- And (S)-Oxazolylphenols
  作者:Scheurer,Andreas; Mosset,Paul; Bauer,Walter; Saalfrank,Rolf W.
  参考文献:European Journal Of Organic Chemistry 日期:2001 卷标:(16) 页码:3067-3074]
  
  5874-57-7 = 93204-36-5
  反应条件:1.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran; 0.5 H,Rt; Rt -> 0 °C1.2 0 °C -> Rt; Overnight,Rt
  标题:Tetrahydroisoquinoline Compound Intermediate,Its Preparation Method And Application
  参考文献:China]
  
  6081-61-4 = 93204-36-5
  反应条件:1.1 Catalysts: Tris(Pentafluorophenyl)Borane Solvents: Methanol; 100 H,36 °C
  标题:Chemo- And Site-Selective Fischer Esterification Catalyzed By B(C6F5)3
  作者:Li,Ya-Lan; Pang,Jin-Yu; Lou,Ji-Cong; Sun,Wen-Wu; Liu,Ji-Kai; Et Al
  参考文献:Asian Journal Of Organic Chemistry 日期:2021 卷标:10(6) 页码:1424-1427]
  
  24184-43-8 = 93204-36-5
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Tetrahydrofuran,Water
  标题:Preparation Of Fused Tricyclic Aminopyrimidines As Cdk Inhibitors For The Treatment Of Abnormal Cellular Proliferation
  参考文献:World Intellectual Property Organization]
  
  312-84-5 = 93204-36-5
  反应条件:1.1 Reagents: Thionyl Chloride; Cooled; 4 H,Rt1.2 Reagents: Sodium Bicarbonate; Overnight,Rt
  标题:Preparation Of Thiazole Derivatives As Err-α Inverse Agonists
  参考文献:World Intellectual Property Organization]
  
  154632-86-7 = 93204-36-5
  反应条件:1.1 Reagents: Boron Trifluoride Etherate,Water Solvents: Chloroform
  标题:Discovery Of Da-1229: A Potent,Long Acting Dipeptidyl Peptidase-4 Inhibitor For The Treatment Of Type 2 Diabetes
  作者:Kim,Heung Jae; Kwak,Woo Young; Min,Jong Pil; Lee,Jae Young; Yoon,Tae Hyun; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2011 卷标:21(12) 页码:3809-3812]
  
  6081-61-4 = 93204-36-5
  反应条件:1.1 Reagents: Cesium Carbonate Solvents: Dimethylformamide; Rt
  标题:Preparation Of Nucleic Acid Binders Having A Hydroxyamine Motif As Protein Synthesis Inhibitors
  参考文献:World Intellectual Property Organization]
  
  503071-00-9 = 93204-36-5
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 2 H
  标题:Enantioselective Synthesis Of Protected D-Serine From Tetrahydrooxazin-4-One Via A Hetero Diels-Alder Reaction
  作者:Panunzio,Mauro; Bandini,Elisa; Campana,Eileen; Vicennati,Paola
  参考文献:Tetrahedron: Asymmetry 日期:2002 卷标:13(19) 页码:2113-2115]
  
  862824-85-9 = 93204-36-5
  反应条件:1.1 Catalysts: Acetyl Chloride Solvents: Methanol; 15 H,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Water; Rt
  标题:Mild And Chemoselective Deacetylation Method Using A Catalytic Amount Of Acetyl Chloride In Methanol
  作者:Yeom,Chang-Eun; Lee,So Young; Kim,Young Jong; Kim,B. Moon
  参考文献:Synlett 日期:2005 卷标:(10) 页码:1527-1530]
  
  5874-57-7 = 93204-36-5
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Ethyl Acetate,Water; 0 °C; 3 H,Rt
  标题:Different Routes To Ampholytic Polydehydroalanine: Orthogonal Versus Simultaneous Deprotection
  作者:Kruse,Jan-Hendrik; Biehl,Philip; Schacher,Felix Helmut
  参考文献:Macromolecular Rapid Communications 日期:2019 卷标:40(10)]
  
  6081-61-4 = 93204-36-5
  反应条件:1.1 Reagents: Acetyl Chloride Solvents: Methanol; 5 Min,0 °C1.2 2 H,0 °C -> Reflux
  标题:Substituted Diaminopropanol Derivatives As Glucosylceramide Synthase Inhibitors For The Treatment Of Diseases And Their Preparation
  参考文献:World Intellectual Property Organization]
  
  312-84-5 = 93204-36-5
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Methanol1.2 Reagents: Sodium Bicarbonate Solvents: Water
  标题:First Stereocontrolled Synthesis Of (S)-Cleonin And Related Cyclopropyl-Substituted Amino Acids
  作者:Esposito,Annamaria; Piras,Pier Paolo; Ramazzotti,Daniela; Taddei,Maurizio
  参考文献:Organic Letters 日期:2001 卷标:3(21) 页码:3273-3275]
  
  13139-17-8 + 312-84-5 = 93204-36-5
  反应条件:1.1 Reagents: Acetyl Chloride Solvents: Methanol; 12 H,0 °C1.2 Reagents: Triethylamine Solvents: Methanol; 12 H,0 °C
  标题:Preparation Of Dipeptide And Tripeptide Epoxy Ketone Protease Inhibitors
  参考文献:World Intellectual Property Organization]
  
  24184-43-8 = 93204-36-5
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Ethyl Acetate,Water; 45 Min,0 °C
  标题:A Modified Fluoro-Pummerer Reaction With Dast And Nis For Synthesis Of β-Amino-α-Fluoro-Sulfides From Corresponding β-Amino-Sulfides
  作者:Chen,Hongju; Hu,Zhanxing; Zhang,Jianxin; Liang,Guangyi; Xu,Bixue
  参考文献:Tetrahedron 日期:2015 卷标:71(14) 页码:2089-2094]
  
  = 93204-36-5 [标题:Reaction Conditions
  标题:Synthesis And Biological Evaluation Of Fluorescent Analogs Of Polymyxin B
  作者:Suda,Hiroyuki; Nozaki,Jin; Yoshihara,Toshitada; Komagoe,Keiko; Oku,Hiroyuki; Et Al
  参考文献:Peptide Science 日期:2012 卷标:48 页码:97-100]
  
  = 93204-36-5 [标题:Reaction Conditions
  标题:The Synthesis Of Substituted (4S)-4-(Hydroxymethyl)Imidazolidin-2-Ones As Novel Protein Kinase C Modulators
  作者:Zhao,Lianyun; Qiao,Lixin; Rong,Suo-Bao; Kozikowski,Alan P.
  参考文献:Tetrahedron Letters 日期:2000 卷标:41(45) 页码:8711-8715]
  
  = 93204-36-5 [标题:Reaction Conditions
  标题:Synthesis Of Tritiated Threonine With A High Specific Activity
  作者:Delacotte,Jean Michel; Galons,Herve; Schott,Dominique; Morgat,Jean Louis
  参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:1991 卷标:29(10) 页码:1141-6

海关参考信息

• 2902300000-甲苯
  2905121000-正丙醇
  2905399001-1,3-丙二醇
  2906210000-苄醇
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• ➥ 防范代码详解
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