CAS: 1071929-08-2; (5-(4-Fluorophenyl)Thiophen-2-yl)(5-Iodo-2-Methylphenyl)Methanone

5-碘-2-甲基苯甲酸置于aluminum (III) Chloride,氯化亚砜,N,N-二甲基甲酰胺体系中,用 氯苯 用作溶剂,化学反应 8.0H,反应生成(5-(4-氟苯基)噻吩-2-基)(5-碘-2-甲基苯基)甲酮
参考文献:2-(4-氟苯基)-5-(5-碘-2-甲基苄基)噻吩的合成,晶体结构,抗肺癌活性
标题:2-(4-氟苯基)-5-(5-碘-2-甲基苄基)噻吩的合成,晶体结构,抗肺癌活性
摘要:以5-碘-2-甲基苯甲酸(2)为起始原料设计的新型杂环化合物2-(4-氟苯基)-5-(5-碘-2-甲基苄基)噻吩(1)合成路线,最后通过ir,1H NMR和单晶x射线晶体学表征.此外,进一步确定了化合物1对三种人肺癌细胞(h20,H2227和h69)的体外抗癌活性,这表明化合物1可能是一种潜在的抗癌剂.
Doi:10.1134/s0022476620070148

专利信息

专利号:US-2017247359-A1
优先权日:2014-09-05
标题 :Process for the preparation of canagliflozin
发明人：VELLANKI SIVA RAM PRASAD; BALUSU RAJA BABU; PILLI RAMAKRISHNA; JAWAJI RAJESWARA ROA; ANNADASU ANKAMA NAYUDU
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of canagliflozin. The process may be effectively implemented on an industrial scale. Several compounds useful as intermediates for the synthesis of canagliflozin (Formula 4, Formula 4a, Formula 4b and Formula 5) are also disclosed. The process involves the reduction of the compound of formula 3 in the presence of a metal hydride and an organic solvent to obtain the compound of formula 4, converting this into a compound of formula 5 which in turn is converted into canagliflozin.

专利号:CN-115260151-A
优先权日:2022-09-02
标 题:Synthesis process of canagliflozin impurity