CAS: 1118-68-9; 2-(Dimethylamino)Acetic Acid

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2491-06-7 13734-36-6 39608-31-6

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CAS号50-00-0 甲醛 | CAS号56-40-6 甘氨酸 | CAS号18319-88-5 N,N-二甲基甘氨酸钠 | CAS号7148-06-3 N,N-二甲基甘氨酸甲酯 | CAS号4229-44-1 N-甲基羟胺盐酸盐 | CAS号6000-59-5 乙醛酸水合物 | CAS号124-40-3 二甲胺 | CAS号298-12-4 乙醛酸 | CAS号79-11-8 氯乙酸 | CAS号33229-89-9 N,N-二甲氨基乙酸乙酯 | CAS号348-67-4 D-蛋氨酸 | CAS号26920-62-7 (carboxylatomet... | CAS号127-19-5 N,N-二甲基乙酰胺(DMAC) | CAS号13256-22-9 N-亚硝基肌氨酸 | CAS号124-38-9 二氧化碳 | CAS号124-40-3 二甲胺 | CAS号50-00-0 甲醛 | CAS号2491-06-7 N,N-二甲基甘氨酸盐酸盐 | CAS号13574-14-6 Acetamide,2-(di... | CAS号18319-88-5 N,N-二甲基甘氨酸钠

在 Leisingera Caerulea Tmpb Oxygenase,氧气,Sodium Ascorbate体系中,用 Aq. Buffer 用作溶剂,化学反应 4.0H,反应生成N,N-二甲基甘氨酸
参考文献:由两种先前错误注释的非血红素铁加氧酶催化有机膦酸盐降解的新微生物途径.
标题:由两种先前错误注释的非血红素铁加氧酶催化有机膦酸盐降解的新微生物途径.
摘要:假设蛋白质的生化功能分配受到许多蛋白质结构超家族功能多样化的挑战.这种多样化对于金属酶来说尤其常见,使得仅基于序列和结构域相似性的功能注释变得不可靠并且常常是错误的.确定这些超家族内功能亚群的生化表征将有助于改进功能注释的生物信息学方法.我们在此描述了两种非血红素铁加氧酶 Tmpa 和 Tmpb 的结构和功能特征,这两种酶由在 350 多种细菌中发现的一对基因组簇基因编码.Tmpa 和 Tmpb 是一对酶(phny 和 Phnz)的功能同系物,可降解 2-氨基乙基膦酸酯,但作用于其天然存在的季铵类似物 2-(三甲基铵)乙基膦酸酯 (Tmaep).Tmpa 是一种铁 (II) 和 2-(氧代) 戊二酸依赖性加氧酶,被误认为是 γ-丁甜菜碱 (γbb) 羟化酶,对 γbb 没有活性,但能有效羟化 Tmaep.然后,产物(R)-1-羟基-2-(三甲基铵基)乙基膦酸酯[(R)-Oh-Tmaep]充
Doi:10.1021/acs.Biochem.9B00044

专利信息

专利号:US-9388131-B2
优先权日:2011-04-27
标题:Automated synthesis of small molecules using chiral, non-racemic boronates
发明人：BURKE MARTIN D; LI JUNQI; GILLIS ERIC P
权利人:UNIV ILLINOIS
摘要:Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:WO-03031376-A1
优先权日:2001-10-12
标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
发明人：MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

专利号:US-2010069644-A1
优先权日:2008-09-15
标题:Method of regio-selective synthesis of tri-substituted-1, 2, 3-triazoles
发明人：SHI XIAODONG
权利人:SHI XIAODONG
摘要:The embodiments provide for region-selective synthesis of tri-substituted 1,2,3-traizoles. A first embodiment provides for the selective N-2 alkylation of a 4,5-disubstituted 1,2,3-triazole. A second embodiment provides for the selective acetylation of a 4,5-disubstituted 1,2,3-triazole. A third embodiment provides for the selective arylation of a 4,5-disubstituted 1,2,3-triazole.

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-10464958-B2
优先权日:2012-07-17
标题 :Method for the synthesis of alpha-aminoalkylenephosphonic acid
发明人：NOTTE PATRICK; COGELS SAMUEL; BURCK SEBASTIAN
权利人:MONSANTO TECHNOLOGY LLC
摘要:The present invention is related to a new method for the synthesis of alpha-aminoalkylenephosphonic acid or its phosphonate esters comprising the steps of forming a reaction mixture by mixing a P—O—P anhydride moiety comprising compound, having one P-atom at the oxidation state (+III) and the other P-atom at the oxidation state (+III) or (+V), an aminoalkanecarboxylic acid and an acid catalyst, wherein said reaction mixture comprises an equivalent ratio of alpha-aminoalkylene carboxylic acid to P—O—P anhydride moieties of at least 0.2, and recovering the resulting alpha-aminoalkylene phosphonic acid compound or an ester thereof from the reaction mixture.