CAS: 120-40-1; N,N-Bis(2-Hydroxyethyl)Dodecanamide

该化合物是一种高纯度表面活性剂,以其极佳的乳化和溶解特性而著称,适合个人护理,制药和工业配方的广泛应用,该产品提供稳定的泡沫形成,减少皮肤刺激,并增强与其他成分的兼容性.

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CAS号112-16-3 十二酰氯 | CAS号111-42-2 二乙醇胺 | CAS号143-07-7 月桂酸 | CAS号111-82-0 月桂酸甲酯 | CAS号645-66-9 月桂酸酐 | CAS号538-24-9 甘油三月桂酸酯 | CAS号106-33-2 月桂酸乙酯 | CAS号25859-09-0 Lauric acid 2-[... | CAS号25859-09-0 Lauric acid 2-[... | CAS号2512-14-3 2-[dodecanoyl(2... | CAS号143-07-7 月桂酸 | CAS号111-42-2 二乙醇胺 | CAS号63056-90-6 2-(2-benzoyloxy... | CAS号63056-92-8 Propanoic acid,...

合成工艺路线路线简述

    二乙醇胺置于magnesol,Sodium Methylate体系中,用 甲醇 用作溶剂,化学反应 1.0H,反应生成N,N-二乙醇十二酰胺
    参考文献:Method Of Making Hydroxyalkyl Amide Containing Reduced Level Of Unreacted Alkanolamine
    标题:Method Of Making Hydroxyalkyl Amide Containing Reduced Level Of Unreacted Alkanolamine
    摘要:一种在金属硅酸盐化合物和可选催化剂的存在下,将烷基醇胺与酯反应,以产生含有降低水平的烷基醇胺和残留催化剂的羟基烷基酰胺组合物的方法.

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    专利信息


    专利号:US-12012427-B2
    优先权日:2019-10-31
    标 题 :Synthesis of Fmoc-protected morpholino monomers and their use in the synthesis of morpholino oligomer
    发明人:SINHA SURAJIT; KUNDU JAYANTA; GHOSH UJJWAL
    权利人:INDIAN ASS FOR THE CULTIVATION OF SCIENCE
    摘要:Present invention relates to stable Fmoc protected Morpholino monomers and corresponding oligonucleotides (PMO) and efficient synthesis of the same involving chlorophosphoramidate and H-Phosphonate chemistry. Successful syntheses of the oligonucleotide with higher yield and lesser time have been accomplished employing solid phase synthesis and easy deprotection of Fmoc group with Piperidine.

    专利号:US-11548898-B2
    优先权日:2017-07-06
    标题 :Synthesis of halichondrins
    发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
    权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
    摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

    专利号:WO-2024153752-A1
    优先权日:2023-01-20
    标 题 :Stereoselective synthesis of intermediates and synthesis of quinagolids
    发明人:RYBERG PER; PINESCHI MAURO; COMPARINI LUCREZIA
    权利人:FERRING BV
    摘要:Disclosed is a method for preparing compounds with improved stereoselectivities. The described compounds are useful intermediates and may find particular application in the synthesis of compounds containing an octahydrobenzoquinoline moiety (e.g. an octahydrobenzo[g]quinoline moiety), such as quinagolide and its derivatives. Also disclosed is a method for stereoselectively (e.g. enantioselectively) preparing an intermediate used in the existing manufacturing process for the synthesis of quinagolide this intermediate also finding utility in the synthesis of other compounds containing an octahydrobenzo[g]quinoline moiety, in particular those having a substituent at the 3- position on the octahydrobenzo[g]quinoline.

    专利号:WO-2022256490-A9
    优先权日:2021-06-03
    标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
    发明人:LOCKWOOD MARK
    权利人:ANTIOS THERAPEUTICS INC
    摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

    专利号:US-11891351-B2
    优先权日:2020-03-20
    标 题 :Synthesis of capsaicin derivatives
    发明人:LAGER ERIK
    权利人:AXICHEM AS
    摘要:The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.

    专利号:US-2025026768-A1
    优先权日:2023-06-30
    标题:Method for the synthesis of axially chiral organoboron compounds
    发明人:PING YIFAN; CHE CHI-MING
    权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
    摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.
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    主要参考文献


    1: National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of Lauric Acid Diethanolamine Condensate (CAS NO. 120-40-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies). Natl Toxicol Program Tech Rep Ser. 1999 Jul;480:1-200. 11(9):1762-6. doi: 10.1039/c4sm02488e.

    合成参考文献


    摘要:Parmeggiani L; Encycl Occup Health and Safety 3rd ed Geneva, Switzerland: International Labour Office p.651 (1983)
    摘要:Rasmussen T et al; Chemosphere 27: 2123-25 (1993)
    摘要:Meylan WM et al; Environ Sci Technol 28: 459-65 (1992)
    摘要:GAUNT IF ET AL; SHORT-TERM FEEDING STUDY OF LAURIC DIETHANOLAMIDE IN RATS; FOOD COSMET TOXICOL 5(4) 497 (1967)
    摘要:NIOSH; National Occupational Exposure Survey (NOES) (1983)
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