CAS: 1575-61-7; 5-Chloropentanoyl Chloride

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5-氯戊腈置于盐酸,氯化亚砜体系中,化学反应生成5-氯代戊酰氯
参考文献:Normant; Voreux,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1950,Vol. 231,P. 703
标题:Normant; Voreux,Comptes Rendus Hebdomadaires Des Seances De L'Academie Des Sciences,1950,Vol. 231,P. 703

专利信息

专利号:US-6107495-A
优先权日:1996-07-24
标题:Thienylcyclohexane derivatives for thienylcyclohexyl synthesis
发明人：CAZAUX JEAN-BERNARD; DAFNIET MICHEL; KAMENKA JEAN-MARC; MANGINOT ERIC
权利人:EXPANSIA SA
摘要:PCT No. PCT/FR97/01382 Sec. 371 Date Jan. 19, 1999 Sec. 102(e) Date Jan. 19, 1999 PCT Filed Jul. 24, 1997 PCT Pub. No. WO98/03498 PCT Pub. Date Jan. 29, 1998Novel thienylcyclohexane derivatives of general formula (I), wherein R' is the 2-thienyl or 3-thienyl radical, R is the cyano radical or a radical of formula -C(O)A, and R2'' is a saturated or unsaturated optionally cyclic hydrocarbon radical, or an aryl radical, are disclosed. Methods for preparing said compounds, and the use thereof as novel industrial products for the synthesis of thienylcyclohexyl derivatives, are also disclosed.

专利号:US-2009264648-A1
优先权日:2008-01-14
标题:Synthesis of pyrazoles
发明人：CHEW WARREN; WANG ZHENG; CHEAL GLORIA; BERTRAND MARTIAL; POTOSKI JOHN; MIRMEHRABI MAHMOUD; NENCINI ARIANNA; ZANALETTI RICCARDO
权利人:WYETH CORP; SIENA BIOTECH SPA
摘要:The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

专利号:US-8487108-B2
优先权日:2005-11-14
标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors
发明人：BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T
权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC
摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.

专利号:US-5559237-A
优先权日:1992-06-05
标题:Process for preparation of 2-oxo-1-piperidinyl derivatives
发明人：RANGANATHAN RAMACHANDRAN S; ARUNACHALAM THANGAVEL; NATALIE JR KENNETH J
权利人:BRACCO INT BV
摘要:The present process involves ring opening and ring closure of compounds containing a tetrahydrofuroyl to provide facile synthesis of compounds containing a piperidin-2-one group of the formula

专利号:US-5364965-A
优先权日:1992-12-09
标题 :Analogs of desferrioxamine B and method for synthesis thereof
发明人：BERGERON JR RAYMOND J
权利人:UNIV FLORIDA
摘要:The invention relates to novel analogs of desferrioxamine, homologs thereof and methods for their synthesis.

专利号:US-5130478-A
优先权日:1989-12-06
标题:Process for the preparation of chlorides of chlorinated carboxylic acids
发明人：GAUTHIER PATRICIA P; LE MOULT MICHEL M; ROCHELLE CLAUDE; SENET JEAN-PIERRE G
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The invention relates to a process for the preparation of chlorides of chlorinated carboxylic acids of formula in which R2 denotes the radical (CH2)n, n being an integer from 2 to 4, or the radical -CH2-C(C6H5)2- and R1 denotes a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms, which consists in reacting the lactones of formula in which R1 and R2 have the above meanings, with phosgene at a temperature of 90 DEG to 180 DEG C., while employing as catalysts trisubstituted phosphine oxides or sulphides. The process according to the invention makes it possible to obtain chlorides of chlorinated carboxylic acids of high purity which exhibit an excellent stability to light and to heat and which are very useful as synthesis intermediates.