CAS: 1640-39-7; 2,3,3-Trimethylindolenine

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2-氟苯甲醚置于双(三甲基硅烷基)氨基钾体系中,用 乙醚,甲苯 用作溶剂,化学反应 20.0H,反应生成2,3,3-三甲基-3H-吲哚
参考文献:通过亲核芳香取代制备吲哚啉
标题:通过亲核芳香取代制备吲哚啉
摘要:描述了一种不寻常的芳族取代基来取代吲哚.使2-(2-甲氧基苯基)乙腈衍生物与各种烷基和芳基li试剂反应以提供相应的吲哚烯产物,天然产物的成分和花青染料,例如吲哚花青绿.该新方法用于合成具有较大官能团耐受性的41种吲哚胺,并将选定的实例进一步转化为相应的吲哚啉染料.关键实验提供了这种亲核芳族取代机理的见解.
Doi:10.1021/acs.Orglett.9B00489

专利信息

专利号:EP-1383732-B1
优先权日:2001-05-04
标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
发明人：BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY
权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT
摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.

专利号:US-4062865-A
优先权日:1974-04-05
标 题:Process for the synthesis of substituted indolenines
发明人：MOGGI PIETRO ANTONIO
权利人:SNAM PROGETTI
摘要:A process for the preparation of substituted indolenines of the formula: ##STR1## wherein R is hydrogen, alkyl, aryl or cycloalkyl, halogen, or a functional group selected from among cyano, hydroxyl, alkoxy, nitro or sulphonic groups, and wherein R 1 , R 2 and R 3 are the same, or different, and are selected from alkyl, aryl or cycloalkyl radicals, comprising reacting in the presence of an organic solvent an aromatic amine of the formula: ##STR2## with a tertiary hydroxyketone of the formula: ##STR3## wherein R, R 1 , R 2 and R 3 have the same meanings as defined above, in the presence of a catalyst selected from mineral acids, organic acids, Lewis acids or ionic exchange resins in acid form, and wherein said aromatic amine is slightly in excess, to form first an imine of the formula: ##STR4## under reaction conditions wherein the solvent is removed by azeotropic distillation, and thereafter continuing the reaction to remove water and cyclizing to the desired indolenines. In a preferred embodiment, 2,3,3-trimethylindolenine is prepared by reacting an excess of aniline with 3-methyl-3-hydroxybutan-2-one in the presence of ZnCl 2 as catalyst utilizing benzene as solvent. The substituted indolenines obtained are useful in production of dyes and other compounds useful in the dyeing and photographic industries.

专利号:US-7056348-B2
优先权日:2001-04-19
标题:5-aryl-1,3,3-trimethyl-2-methylene-indoline derivatives and salts thereof, methods for the production and use of said compounds for the temporary coloration of fibers
发明人：SAUTER GUIDO; BRAUN HANS-JUERGEN; REICHLIN NADIA
权利人:WELLA AG
摘要:A method for the synthesis of 5-aryl-1,3,3,-trimethyl-2-methylene-indoline derivatives of Formula (I) or its salts of Formula (Ia) wherein 1 mole of a 5-aryl-2,3,3-trimethyl-3H-indole derivative of Formula (VII) is reacted for 1 to 44 hours at a temperature of 20° to 180° C. in an apolar, aprotic or polar, protic or polar aprotic solvent with 1 to 50 moles of a compound of Formula R1-A; new compounds of Formulas (I)/(Ia) and (V), obtainable by this method as well as an agent containing at least one compound of Formula (I)/(Ia) and a carbonyl/imine compound for dyeing keratinic fibers and a method for temporarily dyeing keratin fibers, for which the keratin fiber is dyed with the aforementioned agent and the dyeing, so obtained, is removed again at any later time by a sulfite preparation.

专利号:US-2023158176-A1
优先权日:2021-11-23
标题:Near-infrared fluorescent small-molecule probe, synthesis method and application thereof
发明人：QU ZONGJIN; LI HAN; WANG ZHEN; ZHANG SHUSHENG
权利人:UNIV LINYI
摘要:A near-infrared fluorescent small-molecule probe, a synthesis method thereof, and an application thereof are provided. The near-infrared fluorescent small-molecule probe is IR-780-F derived from IR-780, in which the basic structure of IR-780 is retained, an end of an alkyl carbon chain connected with a nitrogen (N) atom is changed by adding a trifluoromethyl group (—CF3) at the end. The IR-780-F shows excellent performance in photostability, targeting cancer cells and fluorescence imaging, and has low toxicity. It can be used for targeting tumor tissues, in vivo near-infrared fluorescence imaging, and photothermal therapy, which realizes an integration of diagnosis and treatment.

专利号:US-6037500-A
优先权日:1996-06-14
标题 :Asymmetric synthesis catalyzed by transition metal complexes with cyclic chiral phosphine ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:The present invention relates to rigid chiral ligands usefull in making catalysts for asymmetric synthesis. More particularly, the present invention relates to new monodentate and bidentate cyclic chiral phosphine ligands which are formed into catalysts to provide high selectivity of the enantiomeric structure of the end-product.

专利号:US-6399787-B1
优先权日:1997-06-13
标 题:Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, beta-amino acids and related compounds via catalytic asymmetric hydrogenation based on chiral monodentate and bidentate phosphines with cyclic ring structures. The ligands contain rigid ring structures.