CAS: 20375-65-9; 3-Phenyl-6-Chloropyridazine

该化合物是一种杂交循环化合物,其特点是在三等和六等的苯基组中以氯组取代了三等和六等的核心,这种结构将多功能作为有机合成的关键中间体,特别是在开发药品,农用化学品和特殊化学品方面. 氯组增强了反应性,使核生殖替代反应成为可能,而苯细胞有助于稳定性和潜在的 -相互作用. 其定义明确的分子框架为在药用化学和材料科学中建设复杂的建筑提供了价值. 化合物的特点是高度纯度和一贯性能,确保了研究和工业应用的可靠性.

结构式图片

相似化合物

58059-29-3 66548-50-3 66548-94-5

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

6-phenyl-2,3,4,5-tetrahydropyridazin-3-one 3,6-dichlorpyridazine phenylboronic acid 6-phenylpyridazin-3(2H)-one 3-methoxy-6-phenylpyridazine 3-phenylpyridazine 3-iodo-6-phenylpyridazine 3-amino-6-phenylpyridazine

合成工艺路线路线简述

    3-苯丙烯溴酸酯置于五氯化磷,Sodium Acetate,三氯氧磷体系中,用 乙醇 用作溶剂,化学反应 26.0H,反应生成3-氯-6-苯基哒嗪
    参考文献:4-氨基-6-苯基-3(2 H)-哒嗪酮的合成:一般步骤
    标题:4-氨基-6-苯基-3(2 H)-哒嗪酮的合成:一般步骤
    摘要:描述了合成3,4-二氯-6-苯基哒嗪5的方法.化合物5用作合成一系列4-氨基-6-苯基-3(2H)-哒嗪酮的中间体.
    Doi:10.1002/jhet.5570200607

    海关参考信息

    专利信息


    专利号:US-7220858-B2
    优先权日:2003-12-23
    标 题 :Synthesis of hydrazine and chlorinated derivatives of bicyclic pyridazines
    发明人:NELSON DEANNA J
    权利人:BARBEAU PHARMA INC
    摘要:The present invention relates to both a novel method of preparing hydralazine hydrochloride and to a novel method of preparing hydrazine derivatives of compounds containing a pyridazine ring, including, for example, pyridazines, phthalazines and other compounds containing the pyridazine ring.

    专利号:WO-2013054302-A1
    优先权日:2011-10-12
    标 题:Method for preparing triaryl(heteroaryl)bismuths, and uses thereof for the synthesis of aromatic or heteroaromatic derivatives
    发明人:CONDON SYLVIE; URGIN KARENE; LEONEL ERIC; AUBE CHRISTOPHE; DUBREUIL DIDIER
    权利人:CENTRE NAT RECH SCIENT; UNIV PARIS VAL DE MARNE; UNIV NANTES I; CONDON SYLVIE; URGIN KARENE; LEONEL ERIC; AUBE CHRISTOPHE; DUBREUIL DIDIER
    摘要:The invention relates to a method for preparing a derivative of formula (I): (A) 3 -Bi, where the A groups, identical or different, are an aryl or heteroaryl radical, optionally substituted by at least one FG group, which can occupy any position on the aryl or heteroaryl ring, two FG groups occupying the same position where appropriate, FG being an electron-donating group or an electron-withdrawing group on the aryl or heteroaryl radical, by reacting an organozinc compound of formula (II): A-Zn-X, where A is as defined above and X is a halogen, with bismuth trichloride BiCl 3 , which leads to the derivative of formula (I) above. The invention can be used for synthesising bifunctionalised derivatives that can be aromatic or heteroaromatic, optionally halogenated, or polyheteroaromatic.

    专利号:US-2005137397-A1
    优先权日:2003-12-23
    标题:Synthesis of hydrazine derivatives of pyridazine

    专利号:US-8257931-B2
    优先权日:2005-01-21
    标题 :Regulation of protein synthesis
    发明人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE
    权利人:WAGNER GERHARD; CHOREV MICHAEL; MOERKE NATHAN JOHN; AKTAS BERTAL HUSEYIN; HALPERIN JOSE; HARVARD COLLEGE
    摘要:A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.

    专利号:US-2011021532-A1
    优先权日:2008-04-22
    标题 :Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
    发明人:POWELL DAVID; LEBRUN MARIE-EVE; BHAT SATHESH; RAMTOHUL YEEMAN K
    权利人:MERCK FROSST CANADA LTD
    摘要:Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

    专利号:US-2010144805-A1
    优先权日:2005-01-21
    标题:Regulation of protein synthesis
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    主要参考文献

    [参考文献]: Mojahidul Islam, Et Al. Synthesis, Antitubercular, Antifungal And Antibacterial Activities Of 6-Substituted Phenyl-2-(3'-Substituted Phenyl Pyridazin-6'-Yl)-2,3,4,5-Tetrahydropyridazin-3-One. Acta Pol Pharm. 2008 May-Jun;65(3):353-62.

    合成参考文献


    摘要:Zhang, J., Science of Synthesis Knowledge Updates, (2010) 4, 270.
    摘要:Li, L.; Biscoe, M. R., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 828.
    摘要:Xing, Y.-K.; Fang, P.; Wang, Z.-H.; Mei, T.-S., Science of Synthesis: Special Topics, (2021) 1, 146.
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