CAS: 2199-59-9; Ethyl 5-Formyl-2,4-Dimethyl-1H-Pyrrole-3-Carboxylate

相似化合物

2436-79-5 253870-02-9 5442-91-1

上下游产品

CAS号2199-51-1 2,4-二甲基-3-吡咯羧酸乙酯 | CAS号68-12-2 N,N-二甲基甲酰胺 | CAS号86770-31-2 3,5-二甲基-1-氢-吡咯-... | CAS号122-51-0 原甲酸三乙酯 | CAS号5442-91-1 4-乙氧羰基-3,5-二甲基吡... | CAS号149-73-5 原甲酸三甲酯 | CAS号56453-92-0 ethyl 5-bromo-2... | CAS号141-97-9 乙酰乙酸乙酯 | CAS号74-90-8 氢氰酸 | CAS号17106-13-7 2,4-二甲基吡咯-3-甲酸 | CAS号452105-33-8 5-[(Z)-(5-Fluor... | CAS号341031-54-7 苹果酸舒尼替尼 | CAS号356068-93-4 5-((Z)-(5-氟-2-氧... | CAS号356068-94-5 Z)-5-(5-氟-2-氧代-... | CAS号557795-19-4 舒尼替尼 | CAS号356068-86-5 N-(2-(二乙基氨基)乙基)... | CAS号625-82-1 2,4-二甲基吡咯 | CAS号253870-02-9 2,4-二甲基-5-醛基-1H... | CAS号23314-05-8 Ethyl 2,4-dimet... | CAS号75534-69-9 1H-Pyrrole-3-ca...

2,4-二甲基吡咯-3,5-二羧酸二乙酯置于水,Potassium Hydroxide,三氯氧磷体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 12.0H,反应生成2,4-二甲基-5-醛基-吡咯-3-甲酸乙酯
参考文献:通过无溶剂脱羧工艺改进苹果酸舒尼替尼的合成
标题:通过无溶剂脱羧工艺改进苹果酸舒尼替尼的合成
摘要:为了寻求舒尼替尼及其苹果酸盐的经济方便的合成方法,通过在实验室规模上使用包括乙酰乙酸乙酯,4-氟苯胺和 N 1,N的 市售材料设计标准实验方案,探索了可扩展合成路线的优化. 1-二乙基乙烷-1,2-二胺.在研究主要反应步骤(包括环化,水解,脱羧,甲酰化和缩合)的基础上,确定了最佳条件,每个步骤的最佳收率分别为94.4,97.6,98.5,97.1,91.0,86.3,85.5,88.2,99.1,分别为97.3和58.7%.5-甲酰基-2,4-二甲基-1 H 的合成方法 通过使用无溶剂脱羧代替传统的在高沸点溶剂中的方法,大大改善了作为重要中间体的-吡咯-3-羧酸.随后的甲酰化反应是直接使用脱羧反应的粗产物的二氯甲烷溶液进行的,因此这两个步骤的合并收率几乎定量.使用最佳合成工艺,舒尼替尼及其盐的总收率基于乙酰乙酸乙酯为67.3%和40.0%.所得数据可作为将来工业化的参考,特别是避免昂贵的溶剂并减少反应时间.
Doi:10.1007/s11164-015-1939-Z

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:WO-2005113561-A1
优先权日:2004-05-20
标 题:Cyclicsulfonate pyrrole indolinones as kinase inhibitors
发明人：TANG PENG CHO; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD
权利人:SUGEN INC; TANG PENG CHO; MILLER TODD ANTHONY; SHIRAZIAN SHAHRZAD
摘要:The invention provides compounds of structure of formula (I), and methods of their synthesis and use. Preferred compounds are useful as therapeutic agents, particularly for protein kinase related disorders such as cancer.

专利号:CN-101333215-A
优先权日:2008-07-29
标题:Synthesis method of sunitinib alkali

专利号:CN-103951602-B
优先权日:2014-03-19
标 题:Synthesis method of pyrrole thiosemicarbazone copper and nickel complexes with antitumor activity

专利号:CN-103951602-A
优先权日:2014-03-19
标 题 :Synthesis method of pyrrole thiosemicarbazone copper and nickel complexes with antitumor activity