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L-赖氨酸置于盐酸,Copper (II) Carbonate Hydroxide,Sodium Hydroxide体系中,用 四氢呋喃,水 用作溶剂,化学反应 50.0H,反应生成N-Boc-N'-Cbz-L-赖氨酸
参考文献:设计,合成和初步活性评估作为氨基酸肽酶n / Cd13抑制剂的新型l-赖氨酸衍生物.
标题:设计,合成和初步活性评估作为氨基酸肽酶n / Cd13抑制剂的新型l-赖氨酸衍生物.
摘要:设计并合成了一类新型的l-赖氨酸衍生物作为氨肽酶n(apn)抑制剂.活性评估表明化合物c7(ic(50)= 9.6 +/-1.3 Microm)和c20(ic(50)= 13.6 +/-1.9 Microm)等同于阳性对照bestatin(ic(50)= 11.3 + /-1.6微米).
Doi:10.2174/092986610791306661

专利信息

专利号:US-2018312534-A1
优先权日:2015-10-16
标题:Fluorescent anticancer platinum drugs
发明人：SARKAR ARINDAM; MANDAL SWADHIN KUMAR; SENGUPTA ANIRUDDHA; BISWAS GOUTAM; DUTTA PRADIP; SHARMA RUPALI; RAJ JUSTIN PAUL; SURYAVANSHI HEMANT; KUMARI SMITA
权利人:INVICTUS ONCOLOGY PVT LTD
摘要:The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.