CAS: 300-08-3; Methyl 1-Methyl-1,2,5,6-Tetrahydropyridine-3-Carboxylate Hydrobromide

专利信息

专利号:CA-2640585-A1
优先权日:2003-02-05
标题 :Synthesis of 2-butyl-3-(2'-(1-trityl-1h-tetrazol-5-yl)biphenyl-4-yl)-1,3-diazaspirol{4,4}-non-ene-4-one

专利号:US-8722887-B2
优先权日:2006-09-22
标 题:Sulfonylpyrazole and sulfonylpyrazoline carboxamidine derivatives as 5-HT6 antagonists
发明人：VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G
权利人:VAN LOEVEZIJN ARNOLD; IWEMA BAKKER WOUTER I; KEIZER HISKIAS G; ZORGDRAGER JAN; VAN DER NEUT MARTINA A W; KRUSE CORNELIS G; ABBVIE BAHAMAS LTD
摘要:This invention concerns compounds of the general formula (1): n nand derivatives thereof, which are antagonists of 5-HT 6 receptors, wherein the symbols have the meanings given in the description. The invention also concerns methods for the preparation of these compounds, to novel intermediates useful for their synthesis, and to uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in treating at least on disease or condition chosen from Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, Alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes.