CAS: 32943-25-2; 3-Chloro-10,11-Dihydro-5H-Dibenzo[b,F]Azepine

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CAS号25961-11-9 5-乙酰基-3-氯亚氨基二苄 | CAS号89-59-8 4-氯-2-硝基甲苯 | CAS号52311-59-8 4-氯-2-硝基溴苄 | CAS号84803-67-8 3-氨基-5-乙酰基亚氨基二苄 | CAS号17321-77-6 盐酸氯米帕明 | CAS号223787-53-9 2-(2-bromophene... | CAS号61523-71-5 7-CHLORO-10,11-...

盐酸氯米帕明置于horseradish Peroxidase Type Vi,双氧水体系中,用 水 用作溶剂,化学反应 11.0H,反应生成3-氯亚氨基二苄
参考文献:Reactive Metabolites Of Desipramine And Clomipramine: The Kinetics Of Formation And Reactivity With Dna
标题:Reactive Metabolites Of Desipramine And Clomipramine: The Kinetics Of Formation And Reactivity With Dna
摘要:Tricyclic Antidepressants (Tcas),Along With Phenothyazines And Some Industrial Chemicals,Are Shown To React With Enzymes That Exhibit Peroxidase Activity. These Reactions Result In The Formation Of Reactive Intermediates Having Unpaired Electrons. The Peroxidase Oxidation And Reactivity Of Two Tcas,Desipramine And Clomipramine,Were Investigated. As A Model Of Peroxidase,Horseradish Peroxidase (Hrp) Was Employed. The Products Of The Peroxidase Catalyzed Oxidation Of Desipramine And Clomipramine Were Identified As N-Dealkylated Compounds Iminodibenzyl And 3-Chloroiminodibenzyl Using The Gc/ms Technique. Both Drugs Formed Broad Uv/vis Absorption Spectra In The Presence Of Hrp And H(2)O(2),Indicating The Formation Of A Radical Cations-Reactive Intermediate Of The Oxidation Reaction. The Dynamics Of The Formation Of The Desipramine Intermediate Was Studied Using Uv/vis Spectroscopy. The Extinction Coefficient Was Measured For The Reactive Intermediate,7.80 X 10(3) M(-1) Cm(-1),As Well As The Apparent Michaelis-Menten And Catalytic Constants,4.4 Mm And 2.3 S(-1),Respectively. Both Desipramine And Clomipramine Degraded Dnain The Presence Of Hrp/h(2)O(2),As Was Revealed By Agarose Gel Electrophoresis And Pci Extraction. Manipulating The Kinetic Parameters Of Drug'S Radical Formation And Determining The Extent Of Degradation To Biomolecules Could Be Potentially Used For Designing Effective Agents Exhibiting Specific Reactivity. Published By Elsevier Ltd.
Doi:10.1016/j.Bmc.2011.10.075

专利信息

专利号:RU-2167152-C2
优先权日:1994-01-04
标 题 :N-substituted azaheterocyclic carboxylic acids or their pharmaceutically acceptable salts, method of their synthesis, pharmaceutical composition based on thereof and method of inhibition of neurogenic inflammation