CAS: 38496-18-3; 2,6-Dichloronicotinic Acid

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40381-90-6 65515-28-8 55304-73-9

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CAS号2402-78-0 2,6-二氯吡啶 | CAS号124-38-9 二氧化碳 | CAS号67-56-1 甲醇 | CAS号55366-30-8 2,6-二氯-3-三氯甲基吡啶 | CAS号40975-40-4 2,6-二羟基烟酸乙酯 | CAS号10026-13-8 五氯化磷 | CAS号10025-87-3 三氯氧磷 | CAS号7664-93-9 硫酸 | CAS号43083-14-3 2-氯-6-苯基烟腈 | CAS号938443-19-7 7-氯-1H-吡啶并[2,3-... | CAS号503000-87-1 2-氯-6-甲氧基烟酸 | CAS号65515-33-5 6-氯-2-甲氧基烟酸 | CAS号16727-43-8 2,6-二甲氧基吡啶-3-羧酸 | CAS号40381-90-6 2,6-二氯烟腈 | CAS号38025-90-0 2-氯-6-羟基烟酸 | CAS号412018-50-9 2,6-二氯-3-乙酰基吡啶 | CAS号938443-20-0 2,4,7-三氯吡啶并[2,3-d]嘧啶 | CAS号187480-15-5 5-溴-2-甲氧基-6-(甲基...

2,6-二氯吡啶置于盐酸,硫酸体系中,用 四氢呋喃,水 用作溶剂,化学反应生成2,6-二氯烟酸
参考文献:一种奥布替尼关键中间体杂环类化合物2,6-二氯烟酸的制备方法
标题:一种奥布替尼关键中间体杂环类化合物2,6-二氯烟酸的制备方法
摘要:本发明涉及一种奥布替尼关键中间体杂环类化合物2,6‑二氯烟酸的制备方法,将2,6‑二氯吡啶加入到四氢呋喃中,0‑5oc滴加氯磺酰异氰酸酯,室温反应完全,反应液加入冰水中淬灭.用有机溶剂萃取,有机层减压浓缩得到2,6‑二氯烟腈.加入硫酸和水回流,反应结束后冷却至室温,用氨水调节ph=8‑9,过滤得到2,6‑二氯烟酰胺.加入水中,用10%盐酸水溶液至ph=1‑2,用有机溶剂萃取,有机层用饱和氯化钠洗,有机层减压浓缩得到2,6‑二氯烟酸粗品.加入有机溶剂,搅拌溶解,用碱水调节ph=9‑10,水相用浓盐酸调节ph=1‑2,析出白色产品2,6‑二氯烟酸.本发明合成路线操作简单,适合工业化生产.

专利信息

专利号:US-8269047-B2
优先权日:2009-07-23
标题 :Synthesis of alpha-halo enones and enals
发明人：ZHANG LIMING; YE LONGWU
权利人:ZHANG LIMING; YE LONGWU; UNIV NEVADA
摘要:A method for preparing an α-halo enal or enone from an unprotected propargyl alcohol and an electrophilic halogen source catalyzed by the combination of a gold catalyst complex and a metal co-catalyst complex is disclosed. The method can be further enhanced by addition of an additive that facilitates suppression of a des-halo derivative.

专利号:WO-2022035790-A1
优先权日:2020-08-12
标题:Synthesis of quinazoline compounds

专利号:CN-101367760-A
优先权日:2008-10-08
标题:Synthesis of 2-chlorine apellagrin

专利号:US-3682932-A
优先权日:1970-11-23
标 题 :2-chloro-6-hydroxynicotinic acid
发明人：BEAMAN ALDEN GAMALIEL; MILLER O NEAL
权利人:HOFFMANN LA ROCHE
摘要:2-Chloro-6-hydroxynicotinic acid, useful as an agent for inhibiting the synthesis of lipids and, consequently, reducing the weight of accumulated fat in warm-blooded animals, is described.

专利号:US-2011021806-A1
优先权日:2009-07-23
标题:Synthesis of alpha-halo enones and enals

专利号:US-8129411-B2
优先权日:2005-12-30
标题:Organic compounds
发明人：EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.