CAS: 3906-16-9; (R)-1-(2-Naphthyl)Ethylamine

相似化合物

1201-74-7 3082-62-0 10420-89-0

上下游产品

(2))-ethanone-(1)-seqtrans-oxime1-(naphthyl-(2))-ethanone-(1)-seqtrans-oxime ammonium formate formamide methyl 2-naphthyl ketone (1S)-1-(2-naphthyl)ethylamine (R)-[1-(naphthalen-2-yl)ethyl]amine (+/-)-(1-[2]naphthyl-ethyl)-urea 1,4-bis-(1-[2]naphthyl-ethyl)-piperazine

2-萘乙酮置于1.) <(Cod)Rh(1,2-Bis((2R,5R)-2,5-Diethylphospholano)-Benzene)>+cf3So3-盐酸,Samarium Diiodide,氢气体系中,用 四氢呋喃 用作溶剂,化学反应 12.5H,反应生成(R)-(+)-1-(2-萘基)乙胺
参考文献:通过cn双键的高度对映选择性加氢催化酮的催化不对称还原胺化
标题:通过cn双键的高度对映选择性加氢催化酮的催化不对称还原胺化
摘要:我们描述了一种方便的,化学选择性的不对称还原胺化程序,用于将酮转化为手性肼和胺.三步法中的关键步骤是对映选择性duphos-Rh催化的n-酰基hydr的cn双键的加氢反应.详细的优化研究表明溶剂,温度和n-酰基对反应的对映选择性和催化效率的影响.还原产物n-酰基肼通过水解或分别用碘化((II)处理转化为肼或胺.
Doi:10.1016/s0040-4020(01)89375-3

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.

专利号:US-9938282-B2
优先权日:2014-02-05
标 题:Expedient synthesis of sitagliptin
发明人：JANAGANI SATYANARAYANA; THADURI VENKATESHWAR KUMAR; VAMARAJU RAVISANKAR
权利人:STEREOKEM INC
摘要:Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.

专利号:US-12344592-B2
优先权日:2020-01-17
标题 :Methods, processes and intermediates for preparing chroman compounds
发明人：KAMBOJ RAJENDER KUMAR; PADIYA KAMLESH JYOTINDRA; PRABAKARAN KAMALAKANNAN; NAIK KUMAR RAM; RAJESH BHAVANI SHANKAR; RAJENDRA GANPATI POWAR; SACHIN SUBHASH INGAWALE; AMIT DATTATRAY KARCHE; SANTOSHKUMAR SHANKAR DANGE; SITARAM RAMBHAU BARVE
权利人:LUPIN LTD
摘要:This disclosure describes an economical and scalable method and process to synthesize the Calcium sensing receptor (CaSR) modulating agent 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid, its intermediates and pharmaceutically acceptable salts therefor. Uses of said intermediates for synthesis of compounds which may be intermediates to the synthesis of 2-methyl-5-((2R,4S)-2-((((R)-1-(naphthalen-1-yl)ethyl)amino)methyl)chroman-4-yl)benzoic acid are also described herein.

专利号:US-2003114679-A1
优先权日:2001-09-12
标 题:Synthesis of enantiomerically pure amino-substituted fused bicyclic rings