CAS: 3946-32-5; 8-Methoxy-8-Oxooctanoic Acid

相似化合物

629-41-4 234081-94-8 1732-09-8

上下游产品

CAS号1732-09-8 辛二酸二甲酯 | CAS号505-48-6 辛二酸 | CAS号67-56-1 甲醇 | CAS号77-78-1 硫酸二甲酯 | CAS号186581-53-3 重氮甲烷 | CAS号13154-28-4 2-nitro cyclo°C... | CAS号149647-86-9 8-(hydroxyamino... | CAS号505-48-6 辛二酸 | CAS号1732-09-8 辛二酸二甲酯 | CAS号382180-17-8 N-羟基-N'-3-吡啶基辛二酰胺 | CAS号41624-92-4 8-氯-8-氧代辛酸甲酯 | CAS号41138-61-8 (R)-(+)-3-羟基-5-... | CAS号821-38-5 十四烷二酸 | CAS号4117-10-6 6-庚烯-1-醇 | CAS号34455-70-4 8-Oxononanoic a... | CAS号35237-62-8 trans-9-dodecen-1-ol

辛二酸置于sodium Hydroxide,三甲基氯硅烷,Porcine Pancreatic Lipase体系中,用 甲醇,水 作为反应溶剂,化学反应 24.0H,反应生成 辛二酸单甲酯
参考文献:前列腺素 E1 的高效不对称合成
标题:前列腺素 E1 的高效不对称合成
摘要:前列腺素 E1 (5) 的不对称全合成已在双组分偶联过程中实现.手性羟基环戊烯酮 6 很容易从呋喃中获得,Ee 为 96%.关键的反应步骤是动力学酶解,然后是原位反转.用 Corey Cbs 催化剂催化不对称还原 γ-碘代乙烯基酮 19 得到具有 >96% Ee 的 ω-侧链 7.使用与二硫氰基铜酸盐的反应进行共轭加成,随后甲硅烷基保护基的温和裂解和甲酯 22 的酶促水解得到高产率的 (-)-Pge15.
DOI:10.1002/(Sici)1099-0690(199910)1999:10<2655::Aid-Ejoc2655>3.0.Co;2-2

专利信息

专利号:US-7875707-B2
优先权日:2002-05-03
标 题:Disaccharides for drug discovery
发明人：MEUTERMANS WIM; WEST MICHAEL; ADAMSON GEORGE; THANH LE GIANG; DRINNAN NICHOLAS B; ABBENANTE GIOVANNI; BECKER BERND; GRATHWOHL MATTHIAS; RAJARATNAM PREMRAJ; TOMETZKI GERALD
权利人:ALCHEMIA LTD
摘要:Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.

专利号:WO-03082792-A1
优先权日:2002-03-28
标 题:Process for synthesis of trans-alkenoic acid, use thereof

专利号:EA-002100-B1
优先权日:1996-12-23
标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

专利号:RO-109730-B1
优先权日:1993-06-11
标 题:Process for the synthesis of dimethyl ester, tetradecandioic acid

专利号:EP-1490320-A1
优先权日:2002-03-28
标题:Process for synthesis of trans-alkenoic acid, use thereof