专利号:US-7411088-B2 优先权日:2004-02-20 标 题:Stereoselective synthesis of a 4,4-disubstituted cyclohexanepropanoic acid 发明人:BRANDS KAREL MARIE JOSEPH; BREWER SARAH ELIZABETH; DAVIES ANTONY JOHN; DOLLING ULF H; HAMMOND DEBORAH CAMILLE; LIEBERMAN DAVID ROSS; SCOTT JEREMY PETER 权利人:MERCK & CO INC; MERCK SHARP & DOHME 摘要:There is provided stereoselective route to a compound of formula I: n nwherein R represents H or an alkali metal, Ar 1 represents 4-chlorophenyl and Ar 2 represents 2,5-difluorophenyl.
专利号:US-8772301-B2 优先权日:2009-12-18 标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof 发明人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D 权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.
专利号:US-2007225520-A1 优先权日:2004-02-20 标题 :Stereoselective Synthesis of a 4,4-Disubstituted Cyclohexanepropanoic Acid
专利号:US-9795613-B2 优先权日:2014-12-10 标题 :GLP-1 receptor modulators 发明人:BOEHM MARCUS F; MARTINBOROUGH ESTHER; MOORJANI MANISHA; TAMIYA JUNKO; HUANG LIMING; YEAGER ADAM R; BRAHMACHARY ENUGURTHI; FOWLER THOMAS; NOVAK ANDREW; MEGHANI PREMJI; KNAGGS MICHAEL; GLYNN DANIEL; MILLS MARK 权利人:CELGENE INT II SÀRL 摘要:Compounds are provided that modulate the glucagon-like peptide 1 (GLP-1) receptor, as well as methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds can act as modulators or potentiators of GLP-1 receptor on their own, or with incretin peptides such as GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where “ â€? represents either or both the R and S form of the compound): n nwhere A, B, C, Y 1 , Y 2 , Z, R 1 , R 2 , R 3 , R 4 , R 5 , W 1 , n, p and q are as defined herein.
专利号:CN-107619386-A 优先权日:2017-08-26 标题 :A kind of aromatic ring [c] carbazole derivatives and its synthesis method
专利号:CN-107573212-B 优先权日:2017-10-13 标 题 :Synthesis method of trans-4-alkyl cyclohexyl benzene structure liquid crystal intermediate and monomer
参考文献:10.1038/ncomms14190 摘要:Meng Q, Hou M, Liu H, Song J, Han B. Synthesis of ketones from biomass-derived feedstock. Nature Communications. 2017 Jan 31;8(1):14190. doi: 10.1038/ncomms14190.