CAS: 456-49-5; 1-Fluoro-3-Methoxybenzene

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CAS号67-56-1 甲醇 | CAS号372-20-3 3-氟苯酚 | CAS号372-18-9 1,3-二氟苯 | CAS号2398-37-0 间溴苯甲醚 | CAS号66107-33-3 (3-methoxypheny... | CAS号536-90-3 间氨基苯甲醚 | CAS号100-66-3 苯甲醚 | CAS号137654-21-8 2－氟－6－甲氧基苯甲酸 | CAS号66107-29-7 三氟甲基磺酸4-甲氧苯酯 | CAS号1250409-84-7 3-methoxyphenyl... | CAS号394-64-9 1-氟-2,3-二甲氧基苯 | CAS号331-64-6 2-氟-4-甲氧基苯甲醛 | CAS号146137-74-8 2-氟-6-甲氧基-苯甲醛 | CAS号458-50-4 4-溴-3-氟苯甲醚 | CAS号450-83-9 4-氟-2-甲氧基苯甲醛 | CAS号450-88-4 2-溴-5-氟苯甲醚 | CAS号331-63-5 2-氟-4-甲氧基苄氯 | CAS号372-20-3 3-氟苯酚 | CAS号331-62-4 3-氟-4-甲氧基苯腈 | CAS号405-09-4 2-氟-4-甲氧基苄醇

在 Potassium Fluoride,18-冠醚-6,Cu(Otf)2体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 18.0H,以54%的收率获得产物间氟苯甲醚
参考文献:Cu-Catalyzed Fluorination Of Diaryliodonium Salts With Kf
标题:Cu-Catalyzed Fluorination Of Diaryliodonium Salts With Kf
摘要:A Mild Cu-Catalyzed Nucleophilic Fluorination Of Unsymmetrical Diaryliodonium Salts With Kf Is Described. This Protocol Preferentially Fluorinates The Smaller Aromatic Ligand On Iodine(Iii). The Reaction Exhibits A Broad Substrate Scope And Proceeds With High Chemoselectivity And Functional Group Tolerance. Dft Calculations Implicate A Cu-I/cu-Iii Catalytic Cycle.
DOI:10.1021/ol4025716

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-10562872-B2
优先权日:2016-02-08
标 题 :Synthesis of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
发明人：DINESS FREDERIK; MELDAL MORTEN; JACOBSEN CHRISTIAN BORCH
权利人:H LUNDBECK AS
摘要:The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.

专利号:US-2013184465-A1
优先权日:2010-09-30
标 题:Process for the synthesis of thio-triazolo-group containing compounds
发明人：DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL
权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE
摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.

专利号:US-6262272-B1
优先权日:1997-11-13
标题 :Method of synthesis of pyrrole amides
发明人：RAGAN JOHN ANTHONY; MAKOWSKI TERESA WOODALL; AM ENDE DAVID JON; CLIFFORD PAMELA JANE; YOUNG GREGORY RANDALL; CONRAD ALYSON KAY; EISENBEIS SHANE ALLEN; QUALLICH GEORGE JOSEPH; ALLEN DOUGLAS JOHN MELDRUM
权利人:PFIZER
摘要:A method for preparing pyrrole-carboxyamides which selectively bind to GABAa receptors; which comprises reacting 1,3-cycloakane-diones with bromoethylacetate followed by reaction of the resulting product with an acid halide followed by reaction with an aromatic amine and finally with an amonium source at an elevated temperature.

专利号:US-8604213-B2
优先权日:2008-10-21
标 题 :Fluorination of aromatic ring systems
发明人：DIMAGNO STEPHEN
权利人:DIMAGNO STEPHEN; NUTECH VENTURES
摘要:This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18 F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.

专利号:US-5098602-A
优先权日:1988-05-11
标题 :Novel halogen-containing ester compounds, and their intermediates, and method of producing the same as well as liquid crystal compositions containing the same and light switching elements
发明人：HIRAI TOSHIHIRO; YOSHIZAWA ATSUSHI; NISHIYAMA ISA; FUKUMASA MITSUO; SHIRATORI NOBUYUKI; YOKOYAMA AKIHISA
权利人:NIPPON MINING CO
摘要:This invention provides a novel halogen-containing ester compound represented by the following general formula (I): ##STR1## (wherein R is an alkyl group, A is selected from a single bond, --O--, --COO-- and --CO--, both of X and Y are halogen atoms or either one of X and Y is a halogen atom and the other is a hydrogen atom, each of m and n is 0 or 1, m+n=0 or 1, each of k and l is an integer of 1 or more, provide k

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