CAS: 4965-33-7; 7-Chloro-2-Methylquinoline

相似化合物

4964-69-6 50593-69-6 4295-06-1

上下游产品

CAS号109-92-2 乙烯基乙醚 | CAS号108-42-9 间氯苯胺 | CAS号123-73-9 2-丁烯醛 | CAS号64-17-5 乙醇 | CAS号10138-89-3 3-甲氧基缩丁醛二甲缩醛 | CAS号141-85-5 间氯苯胺盐酸盐 | CAS号75-07-0 乙醛 | CAS号106237-20-1 1-(m-chlorophen... | CAS号50-00-0 甲醛 | CAS号106237-28-9 β-(m-chloroanil... | CAS号50593-69-6 4,7-二氯-2-甲基喹啉 | CAS号102876-99-3 7-chloro-2-meth... | CAS号149968-11-6 (E)-2-[3-[3-[2-... | CAS号115104-28-4 MK 571钠盐(L 660711钠盐) | CAS号158966-92-8 孟鲁司特 | CAS号120578-03-2 3-[(1E)-2-(7-氯-... | CAS号151767-02-1 孟鲁司特钠 | CAS号177748-00-4 7-氯-2-乙烯喹啉 | CAS号120385-96-8 3,3'-[[[3-[(1E)... | CAS号115125-09-2 [(7-Chloro-2-qu...

2-氨基-4-氯-苯甲醇置于manganese(Iv) Oxide,Chloro[1,3-Bis(2,6-Di-I-Propylphenyl)Imidazol-2-Ylidene]Copper(I),Sodium T-Butanolate体系中,用 二氯甲烷,甲苯 作为反应溶剂,化学反应生成 7-氯喹哪啶
参考文献:喹啉和萘啶的合成通过与β羟基酮的催化逆向醛醇缩合反应的邻-Aminobenzaldehydes或nicotinaldehydes †
标题:喹啉和萘啶的合成通过与β羟基酮的催化逆向醛醇缩合反应的邻-Aminobenzaldehydes或nicotinaldehydes †
摘要:据报道,Cu(i)催化β-羟基酮与邻氨基苯甲醛和烟醛的逆醛醇缩合反应,可高效,高选择性地产生一系列喹啉和萘啶.该反应使用的β-羟基酮,为区域专一酮保护的烯醇化物源通过铜催化复古醛醇ç α-C β键裂解.在现场与反应生成的铜烯醇经历动力学有利环邻-氨基芳基醛以化学和区域选择性方式产生喹啉和萘啶.温和的和弱碱性的反应条件还抑制了强碱性条件下苯甲醛可能发生的副反应,从而提高了反应产率.
DOI:10.1039/c6Ob01452F

专利信息

专利号:US-5126456-A
优先权日:1991-10-17
标题:7-chloroquinaldine synthesis
发明人：SONG ZHIGUO; HUGHES DAVID L
权利人:MERCK & CO INC
摘要:An improved process is described which utilizes tetrachloro-1,4(or 1,2)-quinone as an oxidant in the Doebner-Miller synthesis of 7-chloroquinaldine, a starting material in the preparation of leukotriene antagonists. The process improves yield and eliminates the need of forming a ZnCl 2 complex to isolate the end product.

专利号:WO-2011121091-A1
优先权日:2010-03-31
标题:Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
发明人：KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
权利人:KRKA D D NOVO MESTO; KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
摘要:The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.

专利号:US-2009099367-A1
优先权日:2006-03-06
标题 :Process for preparing a leukotriene antagonist
发明人：BESSA BELLMUNT JORDI; RAFECAS JANE LLORENC; PASTO AGUILA MIREIA; VERDAGUER ESPAULELLA XAVIER; GORDO CAMPON ESTHER
权利人:FARMAPROJECTS S A
摘要:Process for preparing montelukast or a pharmaceutically acceptable salt thereof, especially its sodium salt, that comprises the condensation of an aldehyde and 7-chloro-2-methylquinoline. Moreover, novel intermediates useful for the synthesis of montelukast are described as well as their preparation.

专利号:HU-P0401607-A2
优先权日:2004-08-10
标题 :Synthesis of aminoquinoline derivatives and of their starting materials

专利号:CN-116514711-A
优先权日:2023-04-28
标题:A new process for the synthesis of key intermediates of montelukast sodium

专利号:CN-113862710-A
优先权日:2021-09-17
标 题 :Electrochemical synthesis method of dihydrodipyrazolo [3,4-b:4',3' -e ] pyridine compound