CAS: 549-18-8; Amitriptyline Hydrochloride

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CAS号1159-03-1 5-(3-二甲氨基丙基)-10... | CAS号50-48-6 阿米替林 | CAS号1210-35-1 二苯并环庚酮 | CAS号109-54-6 3-氯-1-(N,N-二甲基)丙胺 | CAS号3433-80-5 邻溴溴苄

阿米替林置于盐酸体系中,用 异丙醇 作为反应溶剂,化学反应生成 盐酸阿米替林
参考文献:阿米替林连续流合成中的多种有机锂反应生成
标题:阿米替林连续流合成中的多种有机锂反应生成
摘要:Abstracta Continuous Flow Protocol For The Preparation Of The Tricyclic Antidepressant (Tca) Amitriptyline Is Reported. The Advantages Of Flow Chemistry When Handling Organometallic Agents As Well As When Performing Reaction With Gases Are Demonstrated. Continuous Multilithiation Combined With Carboxylation And The Parham Cyclization,A Grignard Addition And Thermolytic Water Elimination By Inductive Heating Are Key Features Of The Multistep Protocol.Magnified Image
DOI:10.1002/adsc.201300614

专利信息

专利号:US-5614419-A
优先权日:1991-07-31
标 题 :Reagents and methods for the quantification of amitriptyline or nortriptyline in biological fluids
发明人：ADAMCZYK MACIEJ; FISHPAUGH JEFFREY R; JOHNSON DONALD; HARTTER DARYL E
权利人:ABBOTT LAB
摘要:Immunoassay methods and reagents for the specific quantification of amitriptyline or nortriptyline in a test sample are disclosed employing antibodies prepared with amitriptyline or nortriptyline derivatives of the Formula III: ##STR1## wherein for amitriptyline, R is CH 3 , and for nortriptyline, R is H. The present invention also describes the synthesis of unique fluorescein tracers of the structure of Formula IV and Formula V: ##STR2## wherein for a specific amitriptyline immunoassay, W 1 is a heteroatom linked to the aromatic ring at the 2 or 3 position, and for a specific nortriptyline immunoassay, W 2 is two heteroatoms linked together and attached to the aromatic ring at the 2 or 3 position, and wherein Q is a detectable moiety, preferably fluorescein or a fluorescein derivative.

专利号:EP-1289975-B1
优先权日:2000-04-19
标题:Epoxidized trialkylammonium salt, synthesis method and uses
发明人：LEMAIRE MARC; GOZZI CHRISTEL; BOULON GILBERT; DALPHINET ANDRE
权利人:INST TEXTILE ET CHIMIQUE DE LY
摘要:The invention concerns an epoxidized trialkylammonium salt characterised in that it is selected among salts of general formula (I), wherein: R represents a (CH2)n-A-NH-(CH2)n'-N<+>R1R2R3 group wherein A represents a -CO- or CH2- group; n' and n range between 1 and 20, with n+n' not less than 10; R1, R2 and R3 are C1-C20 alkyl or mono-hydroxyalkyl groups, linear or branched, identical or different; X represents counterion. The invention also concerns a synthesis method for said salts, the use of said salts as chemical grafting agents, a chemical grafting method for substrates and the resulting biocidal and/or bacteriostatic substrates.

专利号:SA-109300046-B1
优先权日:2008-01-22
标题:Synthesis of herbicide clodinafob propragil and metsulfuron methyl

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:US-9751877-B2
优先权日:2012-09-21
标题 :Substituted pyrido[1,2-a]pyrazines for the treatment of neurodegenerative and neurological disorders
发明人：PETTERSSON MARTIN YOUNGJIN; JOHNSON DOUGLAS SCOTT; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; PATEL NANDINI CHATURBHAI; STIFF CORY MICHAEL; TRAN TUAN PHONG; KAUFFMAN GREGORY WAYNE; STEPAN ANTONIA FRIEDERIKE; VERHOEST PATRICK ROBERT
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n nas defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:EP-3660020-A1
优先权日:2008-10-27
标题 :Process for the synthesis of mtor kinase inhibitors