CAS: 83649-48-3; (R)-3-Amino-3-Phenylpropanoic Acid Hydrochloride
该化合物是一个化学化合物,其结构特征包括一个附于丙诺酸碱的苯环,以及乙型位置的氨基化合物.该化合物一般是盐酸,其溶解度在水中提高,使其在各种应用中更加稳定.氨基酸组的存在表明,它可能具有基本特性,而碳oxylic酸组则有助于其酸性特征.这一双重功能允许它参与各种化学反应,包括典型的氨基酸和箱状酸.(R)指出的具体立体化学学表明,原子的特定空间安排可以影响化合物的生物活动和相互作用.这些化合物由于其潜在的治疗用途,往往对药物研发感兴趣.
- 英文名称(R)-3-Amino-3-Phenylpropanoic Acid Hydrochloride
- 中文名称(R)-3-氨基-3-苯基丙酸盐酸盐
- IUPAC名称(R)-3-amino-3-phenylpropanoic acid hydrochloride
- 其它别名(R)-3-氨基-3-苯基丙酸; 氟西汀中间体; R-3-Amino-3-Phenyl-Propionic Acid Hydrochloride
- CAS编号83649-48-3
- MFCD编号:MFCD01076237
- EINECS号:677-035-9
- FDA UNII编号:4P5GR64B2S
- 分子式:C9H12ClNO2
- 分子量:201.65
- 产品CID: 1824786
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
L-3-(N-formylamino)-3-phenylpropionic acid N-(phenylacetyl)-3-amino-3-phenylpropanoic acid 3-Amino-3-phenylpropionic acid benzaldehyde (3R)-N-benzyloxycarbonyl-3-amino-3-phenylpropanoic acid (R)-3-benzamido-3-phenylpropanoic acid (R)-3-(naphthalene-2-sulfonamido)-3-phenylpropanoic acid (R)-N-((R)-7-formyl-2,3-dihydro-2H-chromen-4-yl)-3-(naphthalene-2-sulfonamido)-3-phenylpropanamide合成工艺路线路线简述
- 98-80-6 = 83649-48-3
反应条件:1.1 Catalysts: Di-μ-Hydroxybis[(2,3,9,10-η)-(1S,4S)-5,6,7,8-Tetrafluoro-1,4-Dihydro-2,9-Bis(Phe... Solvents: 1,4-Dioxane,Water; 12 H,50 °C2.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol,Water; 3 H,80 °C2.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 2 H,Rt2.3 Reagents: Hydrochloric Acid,Dowex 50W Solvents: Water; Rt
标题:Rhodium-Catalyzed Asymmetric Addition Of Arylboronic Acids To β-Phthaliminoacrylate Esters Toward The Synthesis Of β-Amino Acids
作者:Nishimura,Takahiro; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(2) 页码:464-465]
15014-25-2 + 155396-71-7 = 83649-48-3
反应条件:1.1 Reagents: Potassium Carbonate Catalysts: N-[(1S,2S)-2-[bis[3-[[3-(Trihydroxysilyl)Propyl]Thio]Propyl]Amino]Cyclohexyl]-N′... (Fe3O4 Magnetic Nanoparticle-Bound) Solvents: Toluene,Water; 48 H,-15 °C2.1 Reagents: Hydrochloric Acid Solvents: Water; 1 H,100 °C
标题:Highly Enantioselective Synthesis Of N-Protected β-Amino Malonates Catalyzed By Magnetically Separable Heterogeneous Rosin-Derived Amino Thiourea Catalysts: A Stereocontrolled Approach To β-Amino Acids
作者:Zhu,Hao; Et Al
参考文献:Chemcatchem 日期:2013 卷标:5(8) 页码:2187-2190]
114251-41-1 = 83649-48-3
反应条件:1.1 Reagents: Dabco Solvents: Dichloromethane; 15 Min,0 °C; 2 H,0 °C; 2 H,Rt2.1 Catalysts: Di-μ-Hydroxybis[(2,3,9,10-η)-(1S,4S)-5,6,7,8-Tetrafluoro-1,4-Dihydro-2,9-Bis(Phe... Solvents: 1,4-Dioxane,Water; 12 H,50 °C3.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol,Water; 3 H,80 °C3.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 2 H,Rt3.3 Reagents: Hydrochloric Acid,Dowex 50W Solvents: Water; Rt
标题:Rhodium-Catalyzed Asymmetric Addition Of Arylboronic Acids To β-Phthaliminoacrylate Esters Toward The Synthesis Of β-Amino Acids
作者:Nishimura,Takahiro; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(2) 页码:464-465]
65451-19-6 = 83649-48-3 + 65414-83-7
反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Water
标题:An Expedient Synthesis Of 6-Arylpiperidine-2,4-Diones By Chain-Extension Of β-Aryl-β-Amino Acids
作者:Leflemme,Nicolas; Et Al
参考文献:Tetrahedron Letters 日期:2001 卷标:42(51) 页码:8997-8999]
141-82-2 + 100-52-7 = 83649-48-3 + 65414-83-7
反应条件:1.1 Reagents: Ammonium Acetate Solvents: Ethanol2.1 Reagents: Triethylamine Solvents: Acetone,Water3.1 Catalysts: Penicillin Amidase (Immobilized On Eupergit) Solvents: Ethanol,Water
标题:A Stereoselective Synthesis Of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester
作者:Cardillo,Giuliana; Et Al
参考文献:Journal Of Organic Chemistry 日期:1998 卷标:63(7) 页码:2351-2353]
= 83649-48-3
反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Solvents: Ethanol,Water; 3 H,80 °C1.2 Reagents: Lithium Hydroxide Solvents: Tetrahydrofuran,Water; 2 H,Rt1.3 Reagents: Hydrochloric Acid,Dowex 50W Solvents: Water; Rt
标题:Rhodium-Catalyzed Asymmetric Addition Of Arylboronic Acids To β-Phthaliminoacrylate Esters Toward The Synthesis Of β-Amino Acids
作者:Nishimura,Takahiro; Et Al
参考文献:Journal Of The American Chemical Society 日期:2010 卷标:132(2) 页码:464-465]
= 83649-48-3
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1 H,100 °C
标题:Highly Enantioselective Synthesis Of N-Protected β-Amino Malonates Catalyzed By Magnetically Separable Heterogeneous Rosin-Derived Amino Thiourea Catalysts: A Stereocontrolled Approach To β-Amino Acids
作者:Zhu,Hao; Et Al
参考文献:Chemcatchem 日期:2013 卷标:5(8) 页码:2187-2190]
65451-19-6 = 83649-48-3 + 65414-83-7
反应条件:1.1 Catalysts: Penicillin Amidase (Immobilized On Eupergit) Solvents: Ethanol,Water
标题:A Stereoselective Synthesis Of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester
作者:Cardillo,Giuliana; Et Al
参考文献:Journal Of Organic Chemistry 日期:1998 卷标:63(7) 页码:2351-2353]
6335-76-8 = 83649-48-3 + 40856-44-8
反应条件:1.1 Reagents: Water Solvents: Isopropanol; 22 H,45 °C1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Enzymic Synthesis Of β-Aryl And β-Heteroaryl-Substituted β-Amino Acid Enantiomers
作者:Tasnadi,Gabor; Et Al
参考文献:Magyar Kemiai Folyoirat 日期:2010 卷标:116(3) 页码:131-136]
1664-54-6 = 83649-48-3 + 65414-83-7
反应条件:1.1 Reagents: Triethylamine Solvents: Acetone,Water2.1 Catalysts: Penicillin Amidase (Immobilized On Eupergit) Solvents: Ethanol,Water
标题:A Stereoselective Synthesis Of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester
作者:Cardillo,Giuliana; Et Al
参考文献:Journal Of Organic Chemistry 日期:1998 卷标:63(7) 页码:2351-2353]
614-19-7 = 83649-48-3 + 65414-83-7
反应条件:1.1 Solvents: Acetone,Water2.1 Reagents: Sodium Bicarbonate Solvents: Water
标题:An Expedient Synthesis Of 6-Arylpiperidine-2,4-Diones By Chain-Extension Of β-Aryl-β-Amino Acids
作者:Leflemme,Nicolas; Et Al
参考文献:Tetrahedron Letters 日期:2001 卷标:42(51) 页码:8997-8999]
614-19-7 = 83649-48-3 + 40856-44-8
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Ethanol1.2 Reagents: Potassium Carbonate Solvents: Water2.1 Reagents: Water Solvents: Isopropanol; 22 H,45 °C2.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Enzymic Synthesis Of β-Aryl And β-Heteroaryl-Substituted β-Amino Acid Enantiomers
作者:Tasnadi,Gabor; Et Al
参考文献:Magyar Kemiai Folyoirat 日期:2010 卷标:116(3) 页码:131-136]
141-82-2 + 100-52-7 = 83649-48-3 + 40856-44-8
反应条件:1.1 Reagents: Ammonium Acetate Solvents: Ethanol; Reflux2.1 Reagents: Thionyl Chloride Solvents: Ethanol2.2 Reagents: Potassium Carbonate Solvents: Water3.1 Reagents: Water Solvents: Isopropanol; 22 H,45 °C3.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Enzymic Synthesis Of β-Aryl And β-Heteroaryl-Substituted β-Amino Acid Enantiomers
作者:Tasnadi,Gabor; Et Al
参考文献:Magyar Kemiai Folyoirat 日期:2010 卷标:116(3) 页码:131-136
Dl-3-氨基-3-苯基丙酸置于青霉素(酰胺)酶,Eupergit,三乙胺体系中,用 乙醇,水,丙酮 作为反应溶剂,化学反应 9.0H,反应生成 (R)-3-氨基-3-苯基丙酸盐酸盐
参考文献:A Stereoselective Synthesis Of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester
标题:A Stereoselective Synthesis Of (2R,3S)-N-Benzoylphenylisoserine Methyl Ester
摘要:
DOI:10.1021/jo9714066
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专利信息
专利号:US-2019276389-A1
优先权日:2015-12-18
标题:Synthesis of aryl cyclohexane ester derivatives useful as sensates in consumer products
发明人：WOS JOHN AUGUST; YELM KENNETH EDWARD; BUNKE GREGORY MARK; FREDERICK HEATH ALAN; REILLY MICHAEL; HAUGHT JOHN CHRISTIAN; SREEKRISHNA KOTI TATACHAR; LIN YAKANG
权利人:PROCTER & GAMBLE
摘要:Personal care compositions, such as oral care and skin care compositions containing a flavor/perfume system comprising one or more coolants. The pleasant cool sensation provided by a coolant is enhanced in terms of quicker onset, greater intensity, impact or longer duration, which improves appeal and acceptability of the compositions to consumers.
专利号:EP-3390352-A1
优先权日:2015-12-18
标题:Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
专利号:CN-108368035-A
优先权日:2015-12-18
标 题 :Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
专利号:WO-2017106279-A1
优先权日:2015-12-18
标 题 :Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
专利号:CA-3007767-A1
优先权日:2015-12-18
标题:Synthesis of cyclohexane ester derivatives useful as sensates in consumer products
专利号:US-9663516-B2
优先权日:2014-12-18
标题:Bicyclic-pyrimidinedione compounds
发明人：OSLOB JOHAN; AUBELE DANIELLE; EVANCHIK MARC; FOX JONATHAN CHARLES; GRILLO MARK; KANE BRIAN; MCDOWELL ROBERT; SONG YONGHONG; ZHONG MIN
权利人:MYOKARDIA INC
摘要:The present invention provides novel bicyclic pyrimidinedione compounds that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.
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参考DOI号:10.1021/jo9714066
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