CAS: 934-32-7; 1H-Benzo[d]Imidazol-2-Amine

• 英文名称1H-Benzo[d]Imidazol-2-Amine
• 中文名称2-氨基苯并咪唑
• IUPAC名称1H-benzo[d]imidazol-2-amine
• 其它别名1H-苯并[d]咪唑基-2-胺; 2-Iminobenzimidazoline; 1H-Benzimidazol-2-Ylamine; 2-Benzimidazolamine
• CAS编号934-32-7
• MFCD编号:MFCD00005596
• EINECS号:213-280-6
• FDA UNII编号:E65DE7521V
• 分子式:C7H7N3
• 分子量:133.15
• 产品CID: 1973694
• 产品分类有机原料→分子砌块→芳杂环类化合物→苯并咪唑类化合物

• 相似结构搜索
• 产品信息参考;;;;
• InChIKey: JWYUFVNJZUSCSM-UHFFFAOYSA-N
• InChI=1S/C7H7N3/c8-7-9-5-3-1-2-4-6(5)10-7/h1-4H,(H3,8,9,10)…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数0.0

相似化合物

物理性质

• 熔点226-230°C
• 沸点235.67 °C at 760 mmHg
• 闪点204.6±10.4 °C
• 密度1.4±0.1 g/cm3
• pKa:11.41±0.10(预测)
• PSA:54.7
• LogP:1.1451
• 折射率1.780
• 蒸汽压0.0±0.8 mmHg at 25°C
• 溶解性<1G/l Slightly Soluble
• 敏感性1.常温常压下稳定，避免氧化物接触。2.具有刺激性，吸入或口服有害，大量使用应穿着适当的防护服。
• 外观形态黄色至米色或浅棕色结晶粉末、晶体或薄片状物
• 储存条件置于阴暗处,密封, 常温干燥保存
• 产品应用该化合物用于合成IMIDAZO[1-2A]苯并咪甲醇.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别急性毒性 类别4(经口)
  急性毒性 类别4(吸入)
  急性毒性 类别4(经皮)
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  特定目标器官毒性 - 单次接触 类别3
  皮肤致敏 类别1
  生殖毒性 类别2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H302 |吞咽有害.
  H332 |吸入有害.
  H312 |皮肤接触有害.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H335 |可能引起呼吸道刺激.
  H317 |可能引起皮肤过敏反应.
  H361 |怀疑对生育能力或胎儿造成损害.
• 防范说明P264-P270-P330-P501
• UN编号NONH for all modes of transport
• 危险品标志Xn
• 安全声明26-36/37/39-22
• 危险类别码22-36/37/38-43
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 615-43-0 = 934-32-7
  反应条件:1.1 Reagents: Triethylamine Catalysts: Cobalt Chloride (Cocl2) Solvents: Dimethyl Sulfoxide; 1 H,Rt1.2 Reagents: Cesium Carbonate Catalysts: 1,10-Phenanthroline,Cobalt Sulfate Solvents: Dimethyl Sulfoxide; 18 H,120 °C
  标题:Synthesis Of Benzimidazoles Via Domino Intra And Intermolecular C-N Cross-Coupling Reaction
  作者:Kondraganti,Lakshmi; Manabolu,Surendra Babu; Dittakavi,Ramachandran
  参考文献:Chemistryselect 日期:2018 卷标:3(42) 页码:11744-11748]
  
  1516-74-1 = 934-32-7
  反应条件:1.1 Reagents: Sodium Bicarbonate,Sodium Carbonate,Sodium Borohydride Catalysts: 2,2′-Spirobi[1,3,2-Benzodithiastannole] Solvents: Tetrahydrofuran,Water
  标题:Reduction Of Azides To Amines Mediated By Tin Bis(1,2-Benzenedithiolate)
  作者:Bosch,Imma; Costa,Anna M.; Martin,Manuel; Urpi,Felix; Vilarrasa,Jaume
  参考文献:Organic Letters 日期:2000 卷标:2(3) 页码:397-399]
  
  29368-88-5 = 934-32-7
  反应条件:1.1 Solvents: Water
  标题:Ph-Dependent Alternative Ring Closure Of Monoacyl 2-Aminobenzamidoximes. A New 2-Aminobenzimidazole Synthesis
  作者:Korbonits,Dezso; Kolonits,Pal
  参考文献:Journal Of Chemical Research 日期:1988 卷标:(7)]
  
  = 934-32-7
  反应条件:1.1 Solvents: Methanol,Water; 1 H,50 °C
  标题:Cyanogen Bromide
  作者:Morris,Joel; Kovacs,Lajos; Ohe,Kouichi
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2015 卷标:1 页码:1-12]
  
  1184-90-3 = 934-32-7
  反应条件:1.1 Solvents: Isopropanol; 5 Min,Rt; 1 H,60 °C; Cooled1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 12 - 14
  标题:Efficient Synthesis Of 2-Arylamino-2-Imidazolines And 2-Aminobenzimidazoles With Aminoiminomethanesulfonic Acid Derivatives
  作者:Mohanazadeh,Farajollah; Nami,Navabe; Hosseini,Samine Sadat
  参考文献:Chinese Journal Of Chemistry 日期:2011 卷标:29(5) 页码:1055-1058]
  
  1516-74-1 = 934-32-7
  反应条件:1.1 Catalysts: Nickel Solvents: Ethanol
  标题:Benzazoles. 2-Hydrazino- And 2-Azidobenzimidazoles
  作者:Bednyagina,N. P.; Postovskii,I. Ya.
  参考文献:Zhurnal Obshchei Khimii 日期:1960 卷标:30 页码:1431-7]
  
  420-04-2 = 934-32-7
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water
  标题:Cyanamide
  作者:Schow,Steven
  参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-3]
  
  = 934-32-7
  反应条件:1.1 Solvents: Acetonitrile,Water; 23 °C
  标题:Preparation Of Substituted Benzimidazoles As Modulators Of Ras Signaling
  参考文献:United States]
  
  1516-74-1 = 934-32-7
  反应条件:1.1 Reagents: Dibutylstannane Solvents: Benzene
  标题:New Synthetic Tricks. [et3Nh][sn(Sph)3] And Bu2Snh2,Two Useful Reagents For The Reduction Of Azides To Amines
  作者:Bartra,Marti; Urpi,Felix; Vilarrasa,Jaume
  参考文献:Tetrahedron Letters 日期:1987 卷标:28(47) 页码:5941-4]
  
  = 934-32-7
  反应条件:1.1 Reagents: Sodium Acetate Catalysts: Copper Sulfate Solvents: Dimethyl Sulfoxide; 1 H,Rt1.2 4 H,Rt1.3 Reagents: Potassium Carbonate Catalysts: 1,10-Phenanthroline,Copper Sulfate; 18 H,120 °C
  标题:Copper-Promoted One-Pot Approach: Synthesis Of Benzimidazoles
  作者:Boddapati,S. N. Murthy; Tamminana,Ramana; Gollapudi,Ravi Kumar; Nurbasha,Sharmila; Assal,Mohamed E.; Et Al
  参考文献:Molecules 日期:2020 卷标:25(8)]
  
  = 934-32-7
  反应条件:1.1 Solvents: Methanol,Water; Rt; Overnight,60 °C; 60 °C -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8
  标题:Preparation Of The Benzimidazole Compound And Their Application For The Preventing And Treating Fak-Related Diseases
  参考文献:China]
  
  28819-30-9 = 934-32-7
  反应条件:1.1 Reagents: Cesium Carbonate Solvents: Water; 10 Min,50 °C
  标题:Method For Synthesizing Benzimidazole Compounds By Using Benzamidine Compound In Water Phase By Microwave Method
  参考文献:China]
  
  113-00-8 = 934-32-7
  反应条件:1.1 Reagents: P-Toluenesulfonic Acid,N-Bromosuccinimide Solvents: Acetonitrile,Water; Rt; 5 Min,Rt1.2 Reagents: Potassium Peroxymonosulfate Sulfate (2Khso5.Khso4.K2So4); 20 Min,Rt1.3 0.5 H,50 °C
  标题:A New Nbs/oxone Promoted One Pot Cascade Synthesis Of 2-Aminobenzimidazoles/2-Aminobenzoxazoles: A Facile Approach
  作者:Daswani,Ujla; Dubey,Nitin; Sharma,Pratibha; Kumar,Ashok
  参考文献:New Journal Of Chemistry 日期:2016 卷标:40(9) 页码:8093-8099]
  
  = 934-32-7
  反应条件:1.1 Solvents: Water; Rt -> 65 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 9,65 °C; 65 °C -> 15 °C
  标题:Heteroaromatic Compounds And Their Preparation And Use In Organic Electronic Devices And The Devices
  参考文献:World Intellectual Property Organization]
  
  7188-38-7 = 934-32-7
  反应条件:1.1 Reagents: Oxygen Catalysts: Palladium Diacetate Solvents: Toluene; 20 H,1 Atm,75 °C; 75 °C -> Rt1.2 Reagents: Hydrochloric Acid; Rt; 6 H,Reflux1.3 Reagents: Sodium Hydroxide Solvents: Water; Basified
  标题:Sustainable Synthesis Of Diverse Privileged Heterocycles By Palladium-Catalyzed Aerobic Oxidative Isocyanide Insertion
  作者:Vlaar,Tjostil; Cioc,Razvan C.; Mampuys,Pieter; Maes,Bert U. W.; Orru,Romano V. A.; Et Al
  参考文献:Angewandte Chemie 日期:2012 卷标:51(52) 页码:13058-13061]
  
  75-12-7 = 934-32-7
  反应条件:1.1 Catalysts: Tetraethoxysilane (Post-Treated With Chlorosulfuric Acid) Solvents: Ethanol; 18 Min,Rt
  标题:Application Of Sulfonic Acid Fabricated Cobalt Ferrite Nanoparticles As Effective Magnetic Nanocatalyst For Green And Facile Synthesis Of Benzimidazoles
  作者:Yadav,Priyanka; Kakati,Praachi; Singh,Preeti; Awasthi,Satish K.
  参考文献:Applied Catalysis 日期:2021 卷标:612]
  
  = 934-32-7
  反应条件:1.1 Catalysts: Cupric Acetate Solvents: Tetrahydrofuran; 3 H,Rt
  标题:A Novel One-Pot Protocol For The Cu-Catalyzed Synthesis Of Nine 2-Aminobenzimidazole Derivatives From O-Phenylenediamine And Trichloroacetonitrile
  作者:Nematpour,Manijeh; Abedi,Elham; Abedi,Elahe
  参考文献:Letters In Organic Chemistry 日期:2019 卷标:16(2) 页码:99-103]
  
  = 934-32-7
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 5 H,Reflux
  标题:An Improved Synthesis,Characterization And Bioevalution Of Schiff Base Containing Benzimidazole Moiety Catalyzed By Methane Sulfonic Acid
  作者:Krishna Rao,N.; Surendra,Babu M. S.; Ramana,N.; Tentu,Nageswara Rao; Basaveswara Rao,M. V.; Et Al
  参考文献:Pharma Chemica 日期:2017 卷标:9(13) 页码:137-140]
  
  10605-21-7 = 934-32-7
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water
  标题:Process For The Preparation Of 2-Aminobenzimidazole
  参考文献:European Patent Organization]
  
  = 934-32-7
  反应条件:1.1 Solvents: Ethanol,Water; 1 H,70 °C1.2 Reagents: Ammonium Hydroxide; Ph 7,Rt
  标题:Synthesis And Antiparasitic Activity Of 1H-Benzimidazole Derivatives
  作者:Valdez,Juan; Cedillo,Roberto; Hernandez-Campos,Alicia; Yepez,Lilian; Hernandez-Luis,Francisco; Et Al
  参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2002 卷标:12(16) 页码:2221-2224

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