专利号:WO-2016097345-A1 优先权日:2014-12-19 标题 :Labelled chromone derivatives 发明人:JACKSON ALEXANDER 权利人:GE HEALTHCARE LTD 摘要:The present invention relates to compounds having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive compounds. The radioactive compounds of the invention are particularly useful for in vivo imaging applications.
专利号:WO-2015088564-A1 优先权日:2013-12-13 标 题:P2x4 receptor modulating compounds 发明人:NEWCOM JASON S; SPEAR KERRY L 权利人:SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are P2X4 receptor modulating compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including but not limited to, chronic pain, neuropathy, inflammatory diseases and central nervous system disorders.
专利号:RU-2194701-C2 优先权日:1995-12-18 标 题 :Derivatives of quinazoline, methods of their synthesis, pharmaceutical composition comprising thereof and method of achievement of anti-angiogenic effect and/or effect of decrease of vascular penetration with their using
参考文献:10.1016/j.bbrc.2023.08.050 摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.