CAS: 139585-70-9; 6-Bromonicotinonitrile

相似化合物

149806-06-4 6311-35-9 889676-37-3

上下游产品

CAS号33252-28-7 6-氯-3-氰基吡啶 | CAS号557-21-1 氰化锌 | CAS号223463-14-7 6-溴吡啶-3-硼酸 | CAS号1060811-36-0 1-(6-bromopyrid... | CAS号39065-54-8 6-苯基烟腈 | CAS号1802-28-4 2,2-联吡啶-5-甲腈

N-((6-Bromopyridin-3-yl)Methylidene)Hydroxylamine置于硫酰氟,Potassium Carbonate体系中,化学反应 12.0H,以340 Mg的收率获得2-溴-5-氰基吡啶
参考文献:So2F2介导的无过渡金属一锅级联过程,用于将初级醇(rch2Oh)转化为腈(rcn)
标题:So2F2介导的无过渡金属一锅级联过程,用于将初级醇(rch2Oh)转化为腈(rcn)
摘要:在不引入"额外碳原子"的情况下,开发了一种新的无过渡金属的单锅级联工艺,用于将醇直接转化为腈.该方案允许将容易获得,廉价和丰富的醇转化为高价值的腈.
Doi:10.1002/ejoc.201900478

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-9505729-B2
优先权日:2014-08-22
标题:Isoxazole analogs as mediators of transcriptional induction of E-cadherin
发明人：LINDSLEY CRAIG W; WATERSON ALEX G; BEAUCHAMP R DANIEL
权利人:UNIV VANDERBILT
摘要:In one aspect, the invention relates to N-((arylamino)alkyl)-5-arylisoxazole-3-carboxamide analogs, derivatives thereof, and related compounds, which are useful as mediators of transcriptional induction of E-cadherin; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders associated with E-cadherin activity using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:US-12358903-B2
优先权日:2016-06-13
标题 :FXR (NR1H4) modulating compounds
发明人：BLOMGREN PETER A; CURRIE KEVIN S; FARAND JULIE; GEGE CHRISTIAN; KROPF JEFFREY E; XU JIANJUN
权利人:GILEAD SCIENCES INC
摘要:The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:US-2008269233-A1
优先权日:2005-08-04
标 题:Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds
发明人：ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN
权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN
摘要:The present invention relates to a class of compounds of general formula (I) n n n n n n n n n n and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R 6 , R 7 and R 10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.