CAS: 318-98-9; Propranolol Hydrochloride

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CAS号75-31-0 异丙胺 | CAS号132005-35-7 (2S)-1-chloro-3... | CAS号90-15-3 1-萘酚 | CAS号20133-93-1 1-Chloro-3-naph... | CAS号2461-42-9 3-(1-萘氧基)-1,2-环氧丙烷 | CAS号108433-49-4 1-chloro-2-acet... | CAS号318-98-9 盐酸普萘洛尔 | CAS号10476-53-6 (+/-)-4-hydroxy... | CAS号10476-54-7 Naphthoxylactic acid | CAS号81907-82-6 5-hydroxy Propr... | CAS号4199-10-4 (S)-(-)-普奈洛尔 盐酸盐 | CAS号318-98-9 盐酸普萘洛尔 | CAS号2050-49-9 2,4-二溴-1-萘酚 | CAS号525-66-6 心得安(普萘洛尔) | CAS号124-38-9 二氧化碳 | CAS号12125-02-9 氯化铵

1-Bromo-3-(1-Naphthyloxy)-2-Propanone置于sodium Tetrahydroborate,甲烷体系中,用 甲醇,5,5-Dimethyl-1,3-Cyclohexadiene,乙醇 作为反应溶剂,化学反应 6.5H,反应生成 盐酸普萘洛尔
参考文献:一种盐酸普萘洛尔的制备方法
标题:一种盐酸普萘洛尔的制备方法
摘要:本发明属于医药化工领域,尤其涉及一种盐酸普萘洛尔的制备方法,包括以下步骤:步骤1:1‑萘酚在氢氧化钠溶液中与1,3‑二溴(碘)丙酮反应,反应生成1‑溴(碘)‑3‑(1‑萘氧基)‑2‑丙酮;步骤2:1‑溴(碘)‑3‑(1‑萘氧基)‑2‑丙酮在有机溶剂中被硼氢化钠还原,反应生成1‑溴(碘)‑3‑(1‑萘氧基)‑2‑丙醇;步骤3:1‑溴(碘)‑3‑(1‑萘氧基)‑2‑丙醇在有机溶剂中与异丙胺反应,反应生成1‑异丙氨基‑3‑(1‑萘氧基)‑2‑丙醇;步骤4:1‑异丙氨基‑3‑(1‑萘氧基)‑2‑丙醇与盐酸成盐,反应生成盐酸普萘洛尔,该方法避免了环氧氯丙烷的使用,更为安全环保,反应过程中没有含环氧乙烷结构的中间体,用药安全性更高.

专利信息

专利号:WO-2020034022-A1
优先权日:2018-08-17
标题 :Synthesis of a fluorophore-class compound, compound produced and use thereof, process for producing white organic light emitting diodes and diodes produced
发明人：TEIXEIRA ALVES DUARTE LUIS GUSTAVO; SEVERO RODEMBUSCH FABIANO; GERMINO JOSÉ CARLOS; FALEREIRO BERBIGIER JÔNATAS; DIB ZAMBON ATVARS TERESA; MEIRA FALEIROS MARCELO
权利人:UNIV FEDERAL DO RIO GRANDE DO SUL UFRGS; UNICAMP
摘要:The present invention relates to the synthesis of a class of fluorophores developed by combining the salicylidene and benzazole classes, and to the compound produced and the technical use thereof in the form of a light emitting diode (WOLED). Said synthesis produces a compound which has advantageous optical and electronic properties and high potential for use in light emitting diodes. The present invention further relates to a process for producing white organic light emitting diodes (WOLEDs) as well as to the diodes produced.

专利号:US-7241900-B2
优先权日:2002-02-12
标题 :Synthesis of indole thiazole compounds as ligands for the Ah receptor
发明人：DELUCA HECTOR F; GRZYWACZ PAWEL K; SICINSKI RAFAL R
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method of synthesizing aromatic ketone compositions of formula I comprising the step of introducing a double bond into the 5 membered ring of the 4,5-dihydro-1,3-azoles moiety of formula II is disclosed. A method of synthesizing aromatic ketone compositions of formula I comprising the step of ring synthesis of the tetrahydro-1,3-azoles of formula XI is also disclosed.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2008207908-A1
优先权日:2007-01-29
标 题:Processes for the preparation of piperidinyl-substituted urea compounds
发明人：GLESS RICHARD D
权利人:ARETE THERAPEUTICS INC
摘要:Disclosed are processes for the synthesis of piperidinyl-substituted urea compounds. This invention further relates to novel intermediates prepared during this synthesis.

专利号:WO-2021258179-A1
优先权日:2020-06-26
标 题:Synthetic mimotope peptides of an antigenic protein from m. tuberculosis, recombinant antibody or fragment thereof, aptamers, use thereof in the diagnosis of tuberculosis and method of diagnosis of tuberculosis
发明人：MORAIS LÉA DUARTE DA SILVA; SANTOS FABIANA DE ALMEIDA ARAÚJO; CUNHA THULIO MARQUEZ; SILVA ROBINSON SABINO DA; SOUZA ALINE GOMES DE; GOULART VIVIAN ALONSO; AZEVEDO FERNANDA VAN PETTEN DE VASCONCELOS; RIELLO FABIANE NUNES; FILHO LUIZ RICARDO GOULART
权利人:UNIV FEDERAL DE UBERLANDIA; IMUNOSCAN ENGENHARIA MOLECULAR LTDA
摘要:The present invention relates to the selection, characterization and synthesis of recombinant peptides that mimic antigenic proteins from Mycobacterium tuberculosis and bind to IgA of individuals with tuberculosis, and also to the selection, characterization and synthesis of aptamers and a recombinant antibody fragment that bind to proteins from M. tuberculosis. The present invention also describes the use both of the peptides and aptamers and the recombinant antibody fragment in methods of diagnosis or platforms for the diagnosis of tuberculosis using biological samples from an individual, such as, for example, body fluids from patients with tuberculosis.