CAS: 512-35-6; Benzenesulfonic Anhydride

上下游产品

苯磺酸 Benzenesulfonic Acid 98-11-3

苯磺酸一水合物置于氯化亚砜体系中,用 苯 作为反应溶剂,化学反应 3.0H,以75%的收率获得产物苯亚磺酸硫醚
参考文献:(+)-Fr900482的形式对映体特异性合成.
标题:(+)-Fr900482的形式对映体特异性合成.
摘要:报道了fk973的对映体特异性合成,因此报道了抗肿瘤抗生素(+)-Fr900482的正式对映体特异性合成.由1-乙烯基甘氨酸制得的苯胺8加到手性环氧化物9中,得到氨基醇12.用9-苯基芴基-9-基保护脂族氮后,保持酸性立体中心不外消旋化,形成氮丙啶14在碱性条件下,通过分子内缩合反应得到偶氮酮15.通过亚甲基化,环氧化和氢解过程实现苄基位置的羟甲基化.通过x射线晶体学分析确定所得醇23的绝对立体化学.23的羟基被氨基甲酰化,然后将芳族胺进行电化学脱保护,然后氧化得到不稳定的羟胺,将其立即作为乙酸26加以保护.用dmp将26氧化,然后乙酰基进行肼解反应,导致反应生成的n-羟氨基酮自发封闭为半缩酮28,可以将其视为fr900482及其衍生物的完全保护的前体.通过酸处理除去保护基并进行乙酰化,得到三乙酸酯fk973.
DOI:10.1021/jo0206521

专利信息

专利号:US-9650355-B2
优先权日:2013-01-31
标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure
发明人：HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL
权利人:KOREA INST SCI & TECH
摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.

专利号:US-2006069270-A1
优先权日:2004-09-27
标 题 :Process for the preparation of 1,3,5-trisubstituted pyrazoles via [3+2] cycloaddition
发明人：SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
权利人:SHAPIRO RAFAEL; ROSSANO LUCIUS T; TENHUISEN KAREN L
摘要:A process for the preparation of 1,3,5-trisubstituted pyrazole compounds, which are useful intermediates in the synthesis of factor Xa inhibitors.

专利号:US-10336912-B2
优先权日:2014-08-01
标 题 :Methods for producing and using aqueous polyurethane/polyacrylate hybrid dispersions and use of said aqueous polyurethane/polyacrylate hybrid dispersions in coating agents
发明人：JAHNS EKKEHARD; MANGEL TIMO; ROESCH CHRISTINE; ROMANATO PAOLA; BURK YENI; PAKUSCH JOACHIM
权利人:BASF SE
摘要:The present invention provides an aqueous polyurethane (PU)-polyacrylate hybrid dispersion obtainable by free radical polymerization of at least one acrylate polymer (A1) in the presence of at least one polyurethane (P1), a process for preparing these aqueous polyurethane-polyacrylate hybrid dispersions, wherein said process comprises a) preparing an aqueous polyurethane dispersion and b) using the polyurethane dispersion thus prepared as raw material for the further synthesis of a polyacrylate dispersion, and the use of the hybrid dispersion thus obtained as binder in filled coating materials, particularly as a binder for flexible roof coatings.

专利号:US-2025263414-A1
优先权日:2022-04-08
标题:An improved process for the preparation of remimazolam
发明人：DHAVARIA SANDEEP; BHOYAR ANIL SHAMRAJ; KUMAR ROHIT; GUPTA CHANDAN KUMAR; SINGH HEMANT KUMAR; GUPTA NITIN; SINGH GOVIND; CABRI WALTER
权利人:FRESENIUS KABI ONCOLOGY LTD
摘要:The present invention relates to an improved process for the preparation of a compound of formula V or a salt thereof, Formula (V) The present invention also provides a process for the preparation of a compound of formula I, used in the synthesis of the compound of formula V, Formula (I) wherein Formula I is Formula Ia, when R is H wherein Formula I is Formula Ib, when R is CH 2 COCH 3 .

专利号:US-4143050-A
优先权日:1977-01-05
标题 :Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds
发明人：ROSSY PHILLIP A; HOFFMANN WERNER; MUELLER NORBERT
权利人:BASF AG
摘要:3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.

专利号:EP-0508725-A1
优先权日:1991-04-09
标题:Novel process for the preparation of 8a-aza-8a-homoerythromycin cyclic iminoethers
发明人：WILKENING ROBERT R
权利人:MERCK & CO INC
摘要:A method of synthesizing cyclic iminoethers of the general structural formula These compounds are macrolides, useful as antibiotics and as intermediates in the synthesis of other macrolide antibiotics.