CAS: 52328-97-9; (1E,6E)-1,7-Bis(3,4-Dimethoxyphenyl)-4,4-Dimethylhepta-1,6-Diene-3,5-Dione

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CAS号160096-59-3 二甲氧基姜黄素 | CAS号74-88-4 碘甲烷 | CAS号123-54-6 乙酰丙酮 | CAS号3142-58-3 3,3-二甲基-2,4-戊二酮 | CAS号120-14-9 藜芦醛； 3,4-二甲氧基苯甲醛

乙酰丙酮置于potassium Carbonate,Sodium Hydroxide体系中,用 四氢呋喃,乙醇,二甲基亚砜 作为反应溶剂,化学反应 72.0H,反应生成 四甲基姜黄素
参考文献:Synthesis And Biological Evaluation Of New Curcumin Derivatives As Antioxidant And Antitumor Agents
标题:Synthesis And Biological Evaluation Of New Curcumin Derivatives As Antioxidant And Antitumor Agents
摘要:Twenty-Four New Compounds Were Prepared,Taking Curcumin As A Lead,In Order To Explore Their Antioxidant And Antitumor Properties. The Capacities Of These Derivatives To Scavenge The 2,2'-Azinobis(3-Ethylbenzothiazoline-6-Sulfonic Acid) Radical Cation (Abts(.+)),And To Protect Human Red Blood Cells (Rbcs) From Oxidative Haemolysis Were Investigated. In Addition,The Percentage Viability Of Different Cell Lines (Hep G2,Wi38,Vero And Mcf-7) Was Tested. The Result Of The Antitumor Testing Was Generally In Accordance With Those Of The Antioxidant Assays. Compounds Which Bear O-Methoxy Substitution To The 4-Hydroxy Function In The Phenyl Ring (7G,5G And 3G) Exhibited Significantly Higher Abts(.+)-Scavenging,Antihaemolysis,And Antitumor Activities Than Other Derivatives. In Addition,Molecular Modelling Studies Were Carried Out For Biologically Active And Inactive Compounds,To Study The Structure-Activity Relationship,With The Aim To Elucidate Which Portions Of The Molecules Are Critical For The Antioxidant And Antitumor Activity.
DOI:10.1007/s00044-012-0116-9