CAS: 675-10-5; 4-Hydroxy-6-Methyl-2-Pyrone

相似化合物

672-89-9 36795-97-8 220809-37-0

上下游产品

3,5-dioxohexanoic acid phenyldiazomethane 4-methoxy-6-(phenylthiomethyl)-2H-pyran-2-one 2,2-dimethyl-6-(2-oxo-2-methylethyl)-4H-1,3-dioxin-4-one 4-methoxy-6-methyl-2H-pyran-2-one 2-methoxy-6-methyl-pyran-4-one 4-benzoyloxy-6-methyl-2-pyrone 4-hydroxy-6-methyl-3-(α-piperidinobenzyl)-2-pyrone

去氢乙酸置于硫酸体系中,用 水 作为反应溶剂,化学反应 0.22H,以96%的收率获得产物4-羟基-6-甲基-2-吡喃酮
参考文献:连续流合成加速含溴结构域蛋白调节剂库的反应生成
标题:连续流合成加速含溴结构域蛋白调节剂库的反应生成
摘要:报告了为一系列 Bcp 调制器库提供关键构建块的连续流程过程.动态混合流反应器成为合成和分离阶段的关键技术,能够处理浆液和悬浮液,同时保持高生产率和可靠性.因此,流动中常见中间体的合成被用于进一步构建基于哒唑酮的库(36 种化合物),旨在提高先导化合物的效力和选择性,同时进一步实现新 Bcp 调节剂家族的构效关系研究.
DOI:10.1002/ejoc.201600222

专利信息

专利号:US-8471045-B2
优先权日:2007-04-03
标题 :Synthesis of statins
发明人：CASAR ZDENKO; MESAR TOMAZ; KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ
权利人:CASAR ZDENKO; MESAR TOMAZ; KOPITAR GREGOR; MRAK PETER; OSLAJ MATEJ; LEK PHARMACEUTICALS
摘要:The process for the synthesis of statins featuring the use of an early intermediate (4R,6S)-6-(dialkoxymethyl)tetrahydro-2H-pyran-2,4-diol which already possesses the desired stereochemistry corresponding to the final statin.

专利号:US-2024308950-A1
优先权日:2022-08-05
标题 :Biorenewable synthesis of hydroxy-hexanoate esters
发明人：HUBER GEORGE; DELL ANNA MARCO NAZARENO
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A method to make mono- or di-hydroxy-hexanoates. Triacetic acid lactone is converted to a δ-hexalactone or a 4-hydroxy-δ-hexalactone intermediate. The intermediate is treated with an acid in the presence of an alcohol to yield a 5-hydroxy-hexanoate or 4,5-dihydroxy-hexanoate.

专利号:US-2025066826-A1
优先权日:2023-08-21
标 题 :Artificial synthesis method for malonyl-coenzyme a (coa) and use thereof
发明人：TAN ZAIGAO; LIU TIANGANG; LI JIAN
权利人:UNIV SHANGHAI JIAOTONG
摘要:An artificial synthesis method for malonyl-CoA and use thereof are provided. By means of heterologous expression of an aminotransferase and a malonyl-CoA reductase, an artificial synthesis pathway for synthesizing malonyl-CoA by using β-alanine (β-ala) as a precursor is constructed as follows: firstly, under catalysis of a transaminase, β-ala transfers amino groups to α-ketonic acid (such as pyruvic acid, oxaloacetic acid, or α-ketoglutaric acid, etc.), to form an intermediate product 3-oxopropanoate and a corresponding amino acid; the 3-oxopropanoate generates malonyl-CoA under the action of the malonyl-CoA reductase. This pathway addresses the defects of the natural malonyl-CoA synthesis pathway, such as low carbon utilization, consumption of energy substance ATP, release of greenhouse gas CO 2 , and strict regulation of pathway enzymes, a pyruvate dehydrogenase (PDH) and an acetyl-CoA carboxylase (ACC), thereby achieving high yielding of products using malonyl-CoA as a precursor, including flaviolin, octanoic acid, phloroglucinol, pentadecaheptaene, natamycin, and spinosad.

专利号:US-6252082-B1
优先权日:1997-01-16
标 题 :Pyridone derivatives, their preparation and their use as synthesis intermediates
发明人：LASSALLE GILBERT; BELLEVERGUE PATRICE; BOURBIER JEAN-CLAUDE; GALTIER DANIEL; MARTIN VALERIE
权利人:SANOFI SYNTHELABO
摘要:The invention concerns compounds of formula (I)in which: R is -NO2 or -NHR3, R3 being hydrogen, -COR4 (R4 selected among (C1-C4) alkyl, aryl and aryl (C1-C4) alkyl, -COOR5 (R5 selected among (C1-C4) alkyl and aryl (C1-C4) alkyl), -CONHR6 or SO2R6 (R6 selected among (C1-C5) alkyl, aryl and aryl(C1-C4) alkyl), -SO2NR7R8 (R7 and R8 independently of each other represent hydrogen or (C1-C4) alkyl or form with the nitrogen atom a morpholine group), aryl (C1-C4) alkyl, R1 is a (C1-C4) alkyl group linear or branched, cyclo (C3-C8) alkyl, aryl optionally substituted, aryl (C1-C4) alkyl optionally substituted, heteroaryl, R2 is a hydrogen atom, a (C1-C4) alkyl or arylmethyl group, X is an oxygen or sulphur atom, a -CH2-, -SO2 or -NR1- group and Y is a hydrogen atom or (C1-C6) alkyl. The invention is applicable to synthesis intermediates.

专利号:WO-0104274-A2
优先权日:1999-07-07
标 题:Ketoacyl synthase domains useful for priming of polyketide synthases
发明人：SMITH STUART; JOSHI ANIL; RANGAN VANGIPURAM; WITKOWSKI ANDRZEJ
权利人:CHILDREN S HOSPITAL OAKLAND RE
摘要:The present invention provides methods to improve the efficiency of priming of a modular polyketide synthase, or to alter the specificity of priming of a polyketide synthase. β-ketoacyl synthase domains with enhanced decarboxylative activity and impaired coupling activity useful for improved or altered loading of polyketide synthases are utilized. Such β-ketoacyl synthases possess a non-nucleophilic amino acid residue at the position corresponding to residue 161 in the rat FAS. The modified β-ketoacylsynthase domain, together with an ACP and acyl transferase domain, constitute a loading module that can be used to prime polyketide synthesis. The loading module is expressed, according to the invention, either in the same polypeptide as the first functional module of the polyketide synthase or as a separate polypeptide with a suitable intermodular linker region to facilitate interaction with the first functional module.

专利号:US-8653223-B2
优先权日:2008-04-16
标题:Transketalized compositions, synthesis, and applications
发明人：SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG
权利人:SELIFONOV SERGEY; GOETZ ADAM EDWARD; JING FENG; SEGETIS INC
摘要:Ketal compounds of the structure I n nand a method of preparation of the compound from polyols and oxocarboxylates, as well as uses thereof.