CAS: 877-43-0; 2,6-Dimethylquinoline

• 英文名称2,6-Dimethylquinoline
• 中文名称2,6-二甲基喹啉
• IUPAC名称2,6-dimethylquinoline
• 其它别名2,6-二甲基喹啉; 26二甲基喹啉
• CAS编号877-43-0
• MFCD编号:MFCD00006762
• EINECS号:212-891-5
• FDA UNII编号:KST0M1T4MB
• 分子式:C11H11N
• 分子量:157.22
• 产品CID: 1886084
• 产品分类有机原料→分子砌块→芳杂环类化合物→喹啉类化合物

• 相似结构搜索
• 产品信息参考;;
• InChIKey: JJPSZKIOGBRMHK-UHFFFAOYSA-N
• InChI=1S/C11H11N/c1-8-3-6-11-10(7-8)5-4-9(2)12-11/h3-7H,1-2H3…
• 计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数0.0

相似化合物

物理性质

• 熔点57-59°C
• 沸点266-267 °C at 760 mmHg
• 闪点106.5±11.3 °C
• 密度1.1±0.1 g/cm3
• pKa:pK1:5.46(+1) (25°C)
• PSA:12.89
• LogP:2.85164
• 折射率1.611
• 蒸汽压0.0±0.5 mmHg at 25°C
• 敏感性常温常压下稳定，避免氧化物接触
• 外观形态白色至几乎白色结晶
• 储存条件惰性气氛,室温
• 产品应用该化合物用于研究结构多样性化学品抑制剂(IC 50值),其重组的人体CYP2B6酶为体外研究目的.

MSDS等安全信息

• GHS象形图
• GHS符号GHS07;
  注释: Exclamation mark
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2
  Aquatic Acute 2
  严重眼刺激 类别2A
• 警示词Warning(警告)
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
  H401 |Toxic to aquatic life
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级IRRITANT
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明26-37/39
• 危险类别码36/37/38
• WGK Germany3.0

欧盟法规

上下游产品

合成工艺路线路线简述

• 109467-00-7 = 877-43-0
  反应条件:1.1 Catalysts: Sodium Tert-Butoxide,[1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene]Chloroc... Solvents: Toluene; 8 H,70 °C
  标题:Synthesis Of Quinolines And Naphthyridines Via Catalytic Retro-Aldol Reaction Of β-Hydroxyketones With Ortho-Aminobenzaldehydes Or Nicotinaldehydes
  作者:Zhang,Song-Lin; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2016 卷标:14(38) 页码:8966-8970]
  
  16078-45-8 = 877-43-0
  反应条件:1.1 Catalysts: 2,2,2-Trifluoroethanol,Chloro[4-Methoxy-2-[1-[(4-Methoxyphenyl)Imino-Kn]Ethyl]Phenyl-Kc][(1,2,3,4,5-η)-...; 20 H,Reflux
  标题:Acceptorless Dehydrogenation Of Nitrogen Heterocycles With A Versatile Iridium Catalyst
  作者:Wu,Jianjun; Et Al
  参考文献:Angewandte Chemie 日期:2013 卷标:52(27) 页码:6983-6987]
  
  16078-45-8 = 877-43-0
  反应条件:1.1 Reagents: Oxygen Catalysts: Aluminum Manganese Oxide Solvents: Mesitylene; 3 H,1 Atm,120 °C
  标题:Efficiently Aerobic Dehydrogenation Of N-Heterocycles And Hydrocarbons Over Mnal Oxides
  作者:Wang,Anwei; Et Al
  参考文献:European Journal Of Organic Chemistry 日期:2023 卷标:26(33)]
  
  46038-60-2 = 877-43-0
  反应条件:1.1 Reagents: Silica,Sodium Nitrite,Water Catalysts: 12-Molybdophosphoric Acid Solvents: Dichloromethane; 35 Min,Rt1.2 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water; Neutralized,Rt
  标题:Molybdatophosphoric Acid/nano2/wet Sio2 As An Efficient System For The Aromatization Of 1,2-Dihydroquinolines Under Mild And Heterogeneous Conditions
  作者:Niknam,Khodabakhsh; Et Al
  参考文献:Synthetic Communications 日期:2007 卷标:37(7) 页码:1091-1096]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Ferric Chloride Hexahydrate Solvents: Carbon Tetrachloride; 2 H,140 °C; 140 °C -> 20 °C1.2 Reagents: Sodium Carbonate Solvents: Water; 0.5 - 1 H,Neutralized
  标题:Synthesis Of Substituted Quinolines By The Reaction Of Anilines With Alcohols And Ccl4 In The Presence Of Fe-Containing Catalysts
  作者:Khusnutdinov,R. I.; Et Al
  参考文献:Russian Chemical Bulletin 日期:2013 卷标:62(1) 页码:133-137]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Chromite (Cr2Feo4); 24 H,Rt; 10 Min,Rt1.2 Reagents: Hydrogen Peroxide Solvents: Water; 120 Min,20 °C1.3 5 Min,20 °C
  标题:One-Pot Oxidative Synthesis Of Substituted Quinolines From Alcohols And Arylamines Catalyzed By Fe(Cro2)2 In Water Medium
  作者:Makhmutov,A. R.
  参考文献:Russian Journal Of Organic Chemistry 日期:2018 卷标:54(8) 页码:1166-1172]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Chromite (Cr2Feo4); 24 H,Rt1.2 Reagents: Hydrogen Peroxide Solvents: Water; 2 H,20 °C1.3 5 Min,Rt
  标题:Fe(Cro2)2-Catalyzed,Photoactivated Oxidative One-Pot Tandem Synthesis Of Substituted Quinolines From Primary Alcohols And Arylamines
  作者:Makhmutov,Aynur R.; Et Al
  参考文献:Chemistry Of Heterocyclic Compounds (New York 日期:2018 卷标:54(3) 页码:369-374]
  
  = 877-43-0
  反应条件:1.1 Reagents: Sodium Dodecyl Sulfate Catalysts: 12-Molybdophosphoric Acid Solvents: Toluene,Water; 1 H,80 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water; Basified
  标题:Micellar-Mediated Phosphomolybdic Acid: Highly Effective Reusable Catalyst For Synthesis Of Quinoline And Its Derivatives
  作者:Chaskar,Atul; Et Al
  参考文献:Synthetic Communications 日期:2010 卷标:40(15) 页码:2336-2340]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Palladium (Nanoparticle Complex With Magnetite And Graphene Oxide) Solvents: Acetonitrile; 8 H,80 °C
  标题:Magnetically Separable Palladium-Graphene Nanocomposite As Heterogeneous Catalyst For The Synthesis Of 2-Alkylquinolines Via One Pot Reaction Of Anilines With Alkenyl Ethers
  作者:Verma,Sanny; Et Al
  参考文献:Tetrahedron Letters 日期:2014 卷标:55(15) 页码:2406-2409]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Acetic Acid; 3 - 4 H,25 °C; 3.5 - 4 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
  标题:High Throughput One Pot Synthesis Of 2-Methylquinolines
  作者:Chandrashekarappa,Kiran Kumar H.; Et Al
  参考文献:Tetrahedron Letters 日期:2013 卷标:54(11) 页码:1368-1370]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Iodine Solvents: Benzene; 2 H,80 °C
  标题:Dual Behavior Of Iodine Species In Condensation Of Anilines And Vinyl Ethers Affording 2-Methylquinolines
  作者:Le,Song Thi; Et Al
  参考文献:Molecules 日期:2016 卷标:21(7) 页码:827/1-827/11]
  
  107-21-1 = 877-43-0
  反应条件:1.1 Reagents: Carbon Tetrachloride Catalysts: Iron Chloride (Fecl3); 8 H,150 °C
  标题:Quinoline Synthesis By The Reaction Of Anilines With 1,2-Diols Catalyzed By Iron Compounds
  作者:Khusnutdinov,Ravil; Et Al
  参考文献:Journal Of Heterocyclic Chemistry 日期:2016 卷标:53(4) 页码:1022-1029]
  
  = 877-43-0
  反应条件:1.1 Solvents: Ethanol; 5 H,30 °C
  标题:Nano N-Tio2 Mediated Selective Photocatalytic Synthesis Of Quinaldines From Nitrobenzenes
  作者:Selvam,Kaliyamoorthy; Et Al
  参考文献:Rsc Advances 日期:2012 卷标:2(7) 页码:2848-2855]
  
  1078-28-0 = 877-43-0
  反应条件:1.1 Reagents: Sodium Tert-Butoxide Catalysts: Bis(1,5-Cyclooctadiene)Nickel,1H-Imidazolium,1,3-Dicyclohexyl-,Tetrafluoroborate(1-) (1:1) Solvents: Toluene; 3 Min,Rt1.2 Solvents: Toluene; 6 H,80 °C
  标题:Nickel-Catalyzed Cross-Coupling Of Anisole Derivatives With Trimethylaluminum Through The Cleavage Of Carbon-Oxygen Bonds
  作者:Morioka,Toshifumi; Et Al
  参考文献:Chemistry Letters 日期:2015 卷标:44(12) 页码:1729-1731]
  
  103-89-9 = 877-43-0
  反应条件:1.1 Reagents: Cupric Acetate Catalysts: Silver Hexafluoroantimonate,Bis(Dichloro(η6-P-Cymene)Ruthenium) Solvents: 1,4-Dioxane; 20 H,140 °C
  标题:Carboxylate-Assisted Ruthenium(Ii)-Catalyzed C-H Activations Of Monodentate Amides With Conjugated Alkenes
  作者:Li,Jie; Et Al
  参考文献:Organic Chemistry Frontiers 日期:2015 卷标:2(9) 页码:1035-1039]
  
  1345697-82-6 = 877-43-0
  反应条件:1.1 Reagents: Oxygen Catalysts: Sodium Thiosulfate,5,6-Bis(5-Methoxy-2-Thienyl)-2,3-Pyrazinedicarbonitrile Solvents: Chloroform,Toluene; 5 - 15 H,25 °C1.2 Reagents: Oxygen Catalysts: N-Hydroxytetrachlorophthalimide,5,6-Bis(5-Methoxy-2-Thienyl)-2,3-Pyrazinedicarbonitrile Solvents: Acetonitrile,Dimethylacetamide; 3 - 5 H,25 °C
  标题:Sequential Photoredox Catalysis For Cascade Aerobic Decarboxylative Povarov And Oxidative Dehydrogenation Reactions Of N-Aryl α-Amino Acids
  作者:Shao,Tianju; Et Al
  参考文献:Advanced Synthesis & Catalysis 日期:2018 卷标:360(9) 页码:1754-1760]
  
  16078-45-8 = 877-43-0
  反应条件:1.1 Reagents: Tert-Butyl Hydroperoxide Catalysts: Palladium Solvents: Water; 18 H,Rt
  标题:Palladium Nanoparticles Stabilized By Metal-Carbon Covalent Bonds As An Expeditious Catalyst For The Oxidative Dehydrogenation Of Nitrogen Heterocycles
  作者:Sun,Xiao-Tao; Et Al
  参考文献:Chemcatchem 日期:2017 卷标:9(13) 页码:2463-2466]
  
  = 877-43-0
  反应条件:1.1 Reagents: Hydrazine Hydrate (1:1) Catalysts: 12-Molybdophosphoric Acid Solvents: Water; 30 Min; 2 H,40 - 50 °C
  标题:Multifunctional Catalysis Of Heteropoly Acid. One-Pot Synthesis Of Quinolines From Nitroarene And Various Aldehydes In The Presence Of Hydrazine
  作者:Hekmatshoar,Rahim; Et Al
  参考文献:Journal Of The Chinese Chemical Society (Taipei 日期:2008 卷标:55(6) 页码:1195-1198]
  
  20531-91-3 = 877-43-0
  反应条件:1.1 Reagents: Styrene,Hydrazine Hydrate (1:1) Catalysts: Tris(2,2′-Bipyridyl)Ruthenium(Ii) Chloride Solvents: Dimethyl Sulfoxide; 7 H,Rt
  标题:Visible-Light Photocatalyzed Deoxygenation Of N-Heterocyclic N-Oxides
  作者:Kim,Kyu Dong; Et Al
  参考文献:Organic Letters 日期:2018 卷标:20(23) 页码:7712-7716]
  
  20531-91-3 = 877-43-0
  反应条件:1.1 Reagents: Benzeneacetic Acid,α-Diazo-,Methyl Ester Catalysts: Copper(Ii) Triflate Solvents: 1,2-Dichloroethane; 12 H,60 °C
  标题:Copper-Catalyzed Oxygen Atom Transfer Of N-Oxides Leading To A Facile Deoxygenation Procedure Applicable To Both Heterocyclic And Amine N-Oxides
  作者:Jeong,Jisu; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2015 卷标:51(32) 页码:7035-7038]
  
  20531-91-3 = 877-43-0
  反应条件:1.1 Reagents: 3,5-Bis(1,1-Dimethylethyl) 1,4-Dihydro-2,6-Dimethyl-3,5-Pyridinedicarboxylate Catalysts: Tris(2,2′-Bipyridyl)Dichlororuthenium(Ii) Hexahydrate Solvents: Acetonitrile; 10 Min,Rt
  标题:Highly Chemoselective Deoxygenation Of N-Heterocyclic N-Oxides Using Hantzsch Esters As Mild Reducing Agents
  作者:An,Ju Hyeon; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2021 卷标:86(3) 页码:2876-2894]
  
  46038-60-2 = 877-43-0
  反应条件:1.1 Reagents: Silica,Water,Sodium Dichromate Dihydrate,Sodium Bisulfate Monohydrate Solvents: Dichloromethane
  标题:Oxidation Of 1,2-Dihydroquinolines Under Mild And Heterogeneous Conditions
  作者:Damavandi,Jafar Asgarian; Et Al
  参考文献:Synthetic Communications 日期:2001 卷标:31(20) 页码:3183-3187]
  
  46038-60-2 = 877-43-0
  反应条件:1.1 Reagents: Sodium Nitrite Catalysts: Silica (Supported-Sulfuric Acid),Sulfuric Acid (Silica Supported) Solvents: Dichloromethane; 50 Min,Rt
  标题:Silica Sulfuric Acid-Promoted Aromatization Of 1,2-Dihydroquinolines By Using Nano2 As Oxidizing Agent Under Mild And Heterogeneous Conditions
  作者:Niknam,Khodabakhsh; Et Al
  参考文献:Catalysis Communications 日期:2007 卷标:8(9) 页码:1427-1430]
  
  = 877-43-0
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1 H,Rt1.2 Solvents: Toluene; Overnight,Reflux
  标题:Visible Light-Driven Decarboxylative Alkylation Of Aldehydes Via Electron Donor-Acceptor Complexes Of Active Esters
  作者:Nie,Fang-Yuan; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2022 卷标:87(2) 页码:1262-1271]
  
  = 877-43-0
  反应条件:1.1 Reagents: Oxygen Catalysts: Alumina,Hydrochloric Acid; 5 Min
  标题:One-Pot Synthesis Of Quinaldine Derivatives By Using Microwave Irradiation Without Any Solvent - A Green Chemistry Approach
  作者:Safari,Javad; Et Al
  参考文献:Journal Of Chemical Sciences (Bangalore 日期:2009 卷标:121(4) 页码:481-484]
  
  34897-84-2 = 877-43-0
  反应条件:1.1 Reagents: Sodium Methoxide Catalysts: 2418686-87-8 Solvents: Methanol; 6 H,Rt
  标题:Half-Sandwich Ruthenium Complexes For One-Pot Synthesis Of Quinolines And Tetrahydroquinolines: Diverse Catalytic Activity In The Coupled Cyclization And Hydrogenation Process
  作者:Yun,Xue-Jing; Et Al
  参考文献:Inorganic Chemistry 日期:2020 卷标:59(11) 页码:7841-7851]
  
  598-32-3 = 877-43-0
  反应条件:1.1 Reagents: Acetic Anhydride Solvents: Tetrahydrofuran; 5 - 10 Min,Rt1.2 Reagents: Copper Diacetate Monohydrate,Silver Hexafluoroantimonate Catalysts: Bis(Dichloro(η6-P-Cymene)Ruthenium); Rt -> 120 °C; 24 - 36 H,120 °C
  标题:Traceless Directing-Group Strategy In The Ru-Catalyzed,Formal [3 + 3] Annulation Of Anilines With Allyl Alcohols: A One-Pot,Domino Approach For The Synthesis Of Quinolines
  作者:Kumar,Gangam Srikanth; Et Al
  参考文献:Organic Letters 日期:2017 卷标:19(10) 页码:2494-2497]
  
  78782-17-9 = 877-43-0
  反应条件:1.1 Reagents: Dimethylzinc,Lithium Tert-Butoxide Solvents: Toluene; 3 H,120 °C
  标题:Znme2-Mediated,Direct Alkylation Of Electron-Deficient N-Heteroarenes With 1,1-Diborylalkanes: Scope And Mechanism
  作者:Jo,Woohyun; Et Al
  参考文献:Journal Of The American Chemical Society 日期:2020 卷标:142(30) 页码:13235-13245]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Gold (Titania-Containing Nanoparticles),Titania (Gold-Containing Nanoparticles); 5 H,30 °C
  标题:One-Pot Photocatalytic Synthesis Of Quinaldines From Nitroarenes With Au Loaded Tio2 Nanoparticles
  作者:Selvam,K.; Et Al
  参考文献:Catalysis Communications 日期:2011 卷标:12(6) 页码:389-393]
  
  = 877-43-0
  反应条件:1.1 Catalysts: Silver,Titania Solvents: Ethanol; 3 H,30 °C
  标题:Cost Effective One-Pot Photocatalytic Synthesis Of Quinaldines From Nitroarenes By Silver Loaded Tio2
  作者:Selvam,K.; Et Al
  参考文献:Journal Of Molecular Catalysis A: Chemical 日期:2011 卷标:351 页码:52-61]
  
  501-60-0 = 877-43-0
  反应条件:1.1 Reagents: Cuprous Iodide Solvents: 1,2-Dichloroethane; 12 H,120 °C
  标题:Copper-Promoted Tandem Reaction Of Azobenzenes With Allyl Bromides Via N=n Bond Cleavage For The Regioselective Synthesis Of Quinolines
  作者:Yi,Xiangli; Et Al
  参考文献:Organic Letters 日期:2015 卷标:17(23) 页码:5836-5839]
  
  = 877-43-0
  反应条件:1.1 Solvents: Tetrahydrofuran; 12 H,Rt
  标题:Blue-Light-Promoted Carbon-Carbon Double Bond Isomerization And Its Application In The Syntheses Of Quinolines
  作者:Chen,Xinzheng; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2017 卷标:15(30) 页码:6349-6352

海关参考信息

• 2902300000-甲苯
  2933310010-吡啶
  2939800000-其他生物碱
• 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
• 详情请参考：📖 海关编码查询和海关进出口税则

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