专利号:US-8546532-B2 优先权日:2008-04-17 标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders 发明人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS 权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC 摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.
专利号:WO-2017109658-A1 优先权日:2015-12-23 标 题:Process for the synthesis of patiromer 发明人:GABOARDI MAURO; PRENDIN RICCARDO; CASTALDI MARTA; CASTALDI GRAZIANO 权利人:RJW PHARMA LLC 摘要:The present invention relates to a process for the synthesis of Patiromer, an active ingredient used in the treatment of hyperkalemia in adults.
专利号:WO-2025007089-A1 优先权日:2023-06-30 标 题:Compositions, methods and kits for nucleic acids synthesis and amplification 发明人:BERKMAN JENNIFER; URBONAS IGNAS; ABREU DANIELA CRUZ; LIU CHENGJING; YEN CHIA AN; ONG KIMBERLIE SOOHOO; WEI WEI; GOMEZ SILVAN MARIA CINTA 权利人:LIFE TECHNOLOGIES CORP; THERMO FISHER SCIENTIFIC BALTICS UAB 摘要:The present disclosure is directed to compositions, methods and kits useful for the synthesis of nucleic acid molecules. More specifically, compositions, methods and kits are provided for the amplification of nucleic acid molecules in an one-step qPCR or RT-qPCR procedure comprising a reverse transcriptase, a DNA polymerase, at least one dNTP, and at least one stabilizing agent, wherein said at least one stabilizing agent increases stability of an assembled polymerase chain reaction.
专利号:US-2012094919-A1 优先权日:2009-03-16 标题 :Use of tripeptides 发明人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO 摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.
专利号:US-11220434-B2 优先权日:2017-05-18 标题:Silicon carbide powder and method of preparing the same using a hydrophobic spherical silica aerogel 发明人:KIM YOUNG HUN; LEE JE KYUN; HWANG HAE JIN; LEE KYOUNG JIN 权利人:LG CHEMICAL LTD; UNIV INHA RES & BUSINESS FOUND 摘要:The present invention relates to a method of preparing ultra-pure silicon carbide in which a super-porous spherical silica aerogel is used as a silica raw material. By preparing the silica aerogel particles using low-cost water glass, a reaction area with respect to a carbon raw material is increased to enable low-temperature synthesis of silicon carbide, the size and shape of silicon carbide powder may be uniformly controlled to prepare ultra-pure silicon carbide, and economic efficiency and productivity of the silicon carbide synthesis may be improved. Thus, it is expected that the silicon carbide powder prepared by the preparation method of the present invention may be provided as an optimized raw material for the preparation of silicon carbide sintered body and single crystal (ingot).
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合成参考文献
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