N-苄氧羰基-L-天门冬氨酸 4-叔丁酯 反应生成叔丁氧羰基-L-天冬氨酸-4-叔丁酯 参考文献:Die Anwendung Der 13 C-Kernresonanzspektroskopie Zur Peptidsynthese-Kontrolle 标题:Die Anwendung Der 13 C-Kernresonanzspektroskopie Zur Peptidsynthese-Kontrolle 摘要:Anhand Einer Achtstufigen合成von N-叔丁基-丁氧基羰基-L-天冬酰胺-β-叔丁基丁酸酯和einiger二肽与脉冲-傅立叶变换13 C-NMR-Spektroskopie Zur合成.死于生灵和甘草酸,然后发出信号的肽peptidschutzgruppenkönnendurch Spektrenvergleich Von Derivaten Zugeordnet Werden. Doi:10.1002/cber.19721051118
专利号:US-2018265547-A1 优先权日:2014-07-18 标 题 :Z-selective olefin metathesis of peptides 发明人:MANGOLD SHANE L; GRUBBS ROBERT H 权利人:CALIFORNIA INST OF TECHN 摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
专利号:US-4769445-A 优先权日:1985-03-04 标 题:Process for the solid phase synthesis of peptides which contain sulfated tyrosine 发明人:COMSTOCK JEANNE; ROSAMOND JAMES D 权利人:PENNWALT CORP 摘要:Peptides and Peptide amides such as cholecystokinin (CCK-8) are synthesized in improved yields and purity by a solid phase process. The requisite protected peptide is elaborated and sulfated on a solid support, deprotected, and cleaved from the solid support to give the total synthesis of CCK-8 on a solid support. Thereafter, the peptide is purified in a single step by ion exchange chromatography to provide analytically pure CCK-8.
专利号:US-11738092-B2 优先权日:2019-12-04 标题:Methods and compositions for synthesis of therapeutic nanoparticles 发明人:WYENT EMILY A; BLUMENFELD CARL M; LAMM ROBERT J 权利人:DANTARI INC 摘要:Improved methods and reactants for the chemical synthesis of therapeutic nanoparticles are provided. The nanoparticles comprise a polymeric core, to which is attached one or more homing molecules and one or more therapeutic agents. Improvements in speed, yield and purity are attained using the methods disclosed herein.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-2023355800-A1 优先权日:2019-12-04 标 题 :Methods and compositions for synthesis of therapeutic nanoparticles
专利号:RU-2742765-C1 优先权日:2017-09-28 标 题:Method for preparing intermediate compound for synthesis of medicinal agent
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
合成参考文献
参考文献:10.1007/bf02146018 摘要:Schröder E, Lübke K. [On peptide synthesis. C-terminal partial sequences of eledoisins and eledoisin analogs]. Experientia. 1964 Jan 15;20(1):19–21. doi: 10.1007/bf02146018.