CAS: 18680-27-8; (1S,2S,3R,5S)-2,6,6-Trimethylbicyclo[3.1.1]Heptane-2,3-Diol

相似化合物

22422-34-0 24047-72-1 84236-04-4

上下游产品

CAS号7785-70-8 蒎烯 | CAS号1845-25-6 (1S,2S,5S)-(-)-... | CAS号29333-13-9 (1RS:2RS)-2-ace... | CAS号29333-19-5 (3R)-3-(benzylo... | CAS号1674-08-4 (E)-pin°Carveol | CAS号917-64-6 甲基碘化镁 | CAS号917-54-4 甲基锂 | CAS号29333-20-8 (1S,3R,5S)-3-(b... | CAS号205116-75-2 2-(2,9,9-TriMet... | CAS号2217-15-4 L-(+)-酒石酸二异丙酯 | CAS号84110-34-9 (2-甲基丙基)硼酸(1S,2... | CAS号90084-43-8 (+)-蒎烷硼烷 | CAS号85167-10-8 正丁基硼酸(1S,2S,3R,... | CAS号76-09-5 频哪醇 | CAS号165881-36-7 4-溴丁基硼酸 (1S,2S,... | CAS号24347-58-8 (2R,3R)-(-)-2,3-丁二醇

Beta-Pinene置于potassium Permanganate,四丁基氯化铵,Potassium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 10.0H,反应生成(1S,2S,3R,5S)-(+)-2,3-蒎烷二醇
参考文献:一种手性邻二醇的合成方法及其产品
标题:一种手性邻二醇的合成方法及其产品
摘要:本发明提供了一种手性邻二醇的合成方法,包括以下步骤:(1)将作为该手性邻二醇的前体的烯烃与二氯甲烷加入到反应装置中,并加入碱;然后在‑50oc至‑15oc的温度下,加入相转移催化剂,再分批加入高锰酸钾或高锰酸钠进行反应,得中间体a;(2)将中间体a加入到反应装置中,搅拌下加入乙醚和石油醚,然后分批加入硼酸;滴加氢氧化钾的水溶液进行反应,得中间体b;(3)将所述中间体b加入到反应装置中,再加入乙醚和水,然后在冰浴冷却条件下,滴加氢氟酸,低温搅拌过夜,制得所述手性邻二醇.本发明使用了廉价的,毒性低的,且环境污染小的高锰酸钾或高锰酸钠作为反应试剂,实现了手性邻二醇类化合物的工业化合成生产.

专利信息

专利号:US-9708354-B2
优先权日:2013-03-15
标 题:Methods for the synthesis of sphingomyelins and dihydrosphingomyelins
发明人：ONICIU DANIELA CARMEN; HECKHOFF STEFAN; OSWALD BENOIT; REBMANN PETER; PEER ANDREAS; GONZALEZ MIGUEL; SAUTER PATRIK
权利人:CERENIS THERAPEUTICS HOLDING SA
摘要:The present invention includes methods for the synthesis of sphingomyelins and dihydrosphingomyelins. The present invention also includes methods for the synthesis of sphingosines and dihydrosphingosines. The present invention further includes methods for the synthesis of ceramides and dihydroceramides.

专利号:WO-2009152051-A1
优先权日:2008-06-12
标题:Synthesis of a macrocyclic hcv protease inhibitor
发明人：WANG PENG
权利人:PHENOMIX CORP; WANG PENG
摘要:The present invention provides a method of synthesis of a macrocyclic compound known as a potent inhibitor of a protease produced by the hepatitis C virus (HCV). Inhibition of the viral protease blocks assembly of mature viral particles in an infected mammalian host. The method of synthesis involves a ring-closing metathesis step using a ruthenium catalyst. Hydrogenation and boronate deprotection provide the HCV protease-inhibitory product.

专利号:US-2010087658-A1
优先权日:1996-08-06
标 题 :Methods and intermediates for synthesis of selective dpp-iv inhibitors
发明人：CAMPBELL DAVID ALAN; LEITAO EMILIA P T; WU ZHEN-PING; WANG PENG
权利人:PHENOMIX CORP
摘要:Methods and intermediates for the synthesis of selective inhibitors of dipeptidyl peptidase IV (DPP-IV) are provided. Coupling of a carboxylate salt with a boro-proline derivative provides a protected form of a DPP-IV inhibitor, which may be deblocked to yield the medicinal compound. The carboxylate salt can be a crystalline form of a sodium salt or a dicyclohexylammonium salt. The inhibitor can be used in the treatment of diabetes.

专利号:US-10669292-B2
优先权日:2014-05-05
标 题 :Synthesis of boronate salts and uses thereof
发明人：HECKER SCOTT; BOYER SERGE
权利人:REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

专利号:US-9862745-B2
优先权日:2004-03-30
标题 :Synthesis of boronic ester and acid compounds
发明人：AMMOSCATO VINCE; BISHOP JOHN E; CHIU FANG-TING; GEISER ACHIM; GOMEZ JEAN-MARC; HETT ROBERT; KOELLNER CHRISTOPH; KULKARNI VITHALANAND R; LO YOUNG; MUNK STEPHEN; PICKERSGILL I FRASER
权利人:MILLENNIUM PHARM INC; MILLENNIUM PHARM INC
摘要:The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of boronic ester and acid compounds, including the peptide boronic acid proteasome inhibitor bortezomib.

专利号:US-2012289733-A1
优先权日:2011-05-11
标 题 :Novel borate derivatives and their applications
发明人：HEISE GLENN L; MYSLINSKA MALGORZATA
权利人:HEISE GLENN L; MYSLINSKA MALGORZATA; ANDERSON DEV CO
摘要:Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.