专利号:US-9006231-B2 优先权日:2008-03-03 标 题:Cephalotaxus esters, methods of synthesis, and uses thereof 发明人:GIN DAVID Y; WILMOT JEREMY; DJABALLAH HAKIM 权利人:SLOAN KETTERING INST CANCER 摘要:The present invention provides novel cephalotaxus esters, syntheses thereof, and intermediates thereto. The invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of using said compounds or compositions in the treatment of proliferative diseases (e.g., benign neoplasm, cancer, inflammatory disease, autoimmune disease, diabetic retinopathy) and infectious disease. The invention further provides methods of using said compounds or compositions in the treatment of multidrug resistant cancer.
专利号:US-7005282-B2 优先权日:2002-01-14 标 题:Enzymes coated with ionic liquid 发明人:KIM MAHN-JOO; LEE JAE KWAN 权利人:POSCO AND POSTECH FOUNDATION 摘要:Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150° C. or below. The ionic liquid-coated enzyme according to the present invention remarkably improves enzyme functions, such as enantioselectivity and stability, when the enzyme which may be lipase is coated with an ionic liquid. Further, even in the case of when the ionic liquid-coated enzyme is reused, the enantiomeric excess, enantioselectivity, and activity are not degenerated. The coated enzyme is usable as a catalyst for providing a chiral intermediate required in the synthesis of chiral pesticides, medicines, natural chemicals, and so on.
专利号:WO-2009148654-A2 优先权日:2008-03-03 标 题:Cephalotaxus esters, methods of synthesis, and uses thereof
专利号:US-2011071097-A1 优先权日:2008-03-03 标题:Cephalotaxus esters, methods of synthesis, and uses thereof
专利号:US-2014171416-A1 优先权日:2008-03-03 标 题 :Cephalotaxus esters, methods of synthesis, and uses thereof
专利号:EP-2260041-A2 优先权日:2008-03-03 标题:Cephalotaxus esters, methods of synthesis, and uses thereof
[参考文献]: C J Lynch, Et Al. Role Of Hepatic Carbonic Anhydrase In De Novo Lipogenesis. Biochem J. 1995 Aug 15;310 ( Pt 1)(Pt 1):197-202. [参考文献]: Lina Baranauskien, Et Al. Intrinsic Thermodynamics Of Ethoxzolamide Inhibitor Binding To Human Carbonic Anhydrase Xiii. Bmc Biophys. 2012 Jun 7:5:12.
合成参考文献
摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 391. 摘要:Roy, M.-N.; Lindsay, V. N. G.; Charette, A. B., Science of Synthesis: Stereoselective Synthesis, (2011) 1, 771. 摘要:Garve, L. K. B.; Werz, D. B., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 57. 摘要:Zeitler, K., Science of Synthesis, (2019) , 327. 摘要:S125 | FLUOROIONS | Fluorinated Ionic Liquids Suspect List | DOI:10.5281/zenodo.15348301.