CAS: 5093-64-1; 2-Acetamido-5-Nitropyridine

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29958-14-3 329042-48-0 90765-02-9

上下游产品

5-nitro-pyridin-2-ylamine acetic anhydride acetyl chloride dmap N-(5-aminopyridin-2-yl)acetamide 7H7N3O3*C7H8O3SC7H7N3O3*C7H8O3S benzoyl chloride 3,5-di-O-benzoyl-2-C-methyl-D-ribono-γ-lactone 2-C-methyl-D-ribono-1,4-lactone

2-氨基-5-硝基吡啶,N,N-二甲基乙酰胺置于n,N'-羰基二咪唑体系中,化学反应 6.0H,以70%的收率获得产物2-乙酰胺基-5-硝基吡啶
参考文献:用n,N-羰基二咪唑方便地将n,N-二甲基乙酰胺中的胺进行n-乙酰化
标题:用n,N-羰基二咪唑方便地将n,N-二甲基乙酰胺中的胺进行n-乙酰化
摘要:在存在n,N-羰基二咪唑(cdi)的情况下,二甲基乙酰胺(dmac)可作为乙酰基和二甲基胺气体的有效来源.将胺添加到反应混合物中以非常好至优异的产率递送相应的酰胺.本文报道的胺的乙酰化依赖于在120-125oc下用cdi加热dmac时原位反应生成n-乙酰基咪唑,它是其他乙酰化方法的便捷替代方法.
DOI:10.1016/j.Tetlet.2015.04.077

专利信息

专利号:US-2022356182-A1
优先权日:2009-03-27
标题 :Inhibitors of hepatitis c virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOLL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-11053243-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; LUDMERER STEVEN W; LIU KUN; WU HAO; SOIL RICHARD; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

专利号:US-9090661-B2
优先权日:2009-03-27
标 题:Inhibitors of hepatitis C virus replication
发明人：COBURN CRAIG A; MCCAULEY JOHN A; LUDMERER STEVEN W; LIU KUN; VACCA JOSEPH P; WU HAO; HU BIN; SOLL RICHARD; SUN FEI; WANG XINGHAI; YAN MAN; ZHANG CHENGREN; ZHENG MINGWEI; ZHONG BIN; ZHU JIAN
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.