CAS: 636-21-5; O-Toluidine Hydrochloride

上下游产品

1-methyl-2-nitrobenzene o-toluidineo-toluidine 2'-methylformanilideMesitol 2,3,4,6-tetramethylaniline 2,4,6-trimethylaniline N,N-dimethyl-o-toluidine

甲基硝基苯置于二乙基硅烷,四(3,5-二(三氟甲基)苯基)硼酸钠,Co(Dppbsa),盐酸体系中,用 甲苯,乙醚 作为反应溶剂,以81 %的收率获得产物2-甲基苯胺 盐酸盐
参考文献:Co(Dppbsa)-Catalyzed Reductive N,N-Dimethylation Of Nitroaromatics With Co2 And Hydrosilane
标题:Co(Dppbsa)-Catalyzed Reductive N,N-Dimethylation Of Nitroaromatics With Co2 And Hydrosilane
摘要:合成了一种新型半夹心 Co(dppbsa)([co]),并用于催化硝基芳烃与二氧化碳和氢硅烷的 N,N-二甲基化反应.该催化剂还能高效地将硝基芳烃还原成芳香胺.
DOI:10.1039/d3Gc02517A

专利信息

专利号:US-2024059701-A1
优先权日:2021-04-22
标 题 :Methods for Synthesis of an Advantageous N-Heterocyclic Carbene Catalyst
发明人：CAHANA AVIAD; FARONE WILLIAM A
权利人:XF TECH INC
摘要:The present invention concerns the synthesis of the salts of a Triazolium N-Heterocyclic Carbene (NHC) catalyst in various salt forms prepared from 2-methylaniline, 2-methylphenylhydrazine hydrochloride or 2-methylphenylhydrazine. The molecules so prepared are useful in catalysis of carbene reactions and are advantageous due to their lack of chlorinated or fluorinated intermediates and lack of chlorine or fluorine in the final structure.

专利号:US-6086852-A
优先权日:1997-11-13
标 题:In vivo stain composition, process of manufacture, and methods of use to identify dysplastic tissue
发明人：BURKETT DOUGLAS D
权利人:ZILA INC
摘要:PCT No. PCT/US97/20981 Sec. 371 Date May 20, 1999 Sec. 102(e) Date May 20, 1999 PCT Filed Nov. 13, 1997 PCT Pub. No. WO99/25388 PCT Pub. Date May 27, 1999N-demethylated and N,N-demethylated derivatives of toluidine blue O and compositions which include these derivatives and the conformational isomers of toluidine blue O. Improved methods for the detection of dysplastic oral tissue using such compositions. Processes for synthesis of toluidine blue O products, in which a complexing agent is introduced prior to the last stage of oxidation of a three-step synthesis from N,N-dimethyl- rho -phenylenediamine. An HPLC method for characterizing toluidine blue O products in which the mobile phase is an aqueous solution of an organic acid.

专利号:US-4148788-A
优先权日:1978-01-23
标 题:Synthesis of thymosin α1
发明人：WANG SU-SUN
权利人:HOFFMANN LA ROCHE
摘要:Thymosin α 1 , was chemically synthesized by the fragment condensation of the protected amino terminal tetradecapeptide with the protected carboxyl terminal tetradecapeptide and by solid phase peptide synthesis. Thymosin α 1 is active as an agent which affects regulation, differentiation and function of thymus dependent lymphocytes (T cells).

专利号:US-3953416-A
优先权日:1971-12-20
标 题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for manufacturing the same
发明人：FOLKERS KARL; CURRIE BRUCE L; CHANG JAW-KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
权利人:FOLKERS KARL; CURRIE BRUCE L; CHANG JAW KANG; SIEVERTSSON HANS; BOGENTOFT CONNY
摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide which has the hormonal activities of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is produced by utilizing as the key starting materials, the amino acids, glutamic acid or pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, and proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate combinations of appropriate protected forms of the amino acids, and finally deprotecting to yield the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.

专利号:US-6372904-B2
优先权日:1997-11-13
标 题 :Process for manufacture of in vivo stain composition
发明人：BURKETT DOUGLAS D
权利人:ZILA INC
摘要:A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N'-dimethyl-rho-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10° C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.

专利号:US-3974135-A
优先权日:1971-06-24
标题:Synthetic decapeptide having the activity of the luteinizing hormone releasing hormone and method for producing the same
发明人：FOLKERS KARL; SIEVERTSSON HANS
权利人:FOLKERS KARL; SIEVERTSSON HANS
摘要:A synthetic decapeptide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide having the hormonal activity of the luteinizing hormone releasing hormone (LRH) of the hypothalamus gland of mammals is provided by utilizing, as key starting materials, the amino acids, pyroglutamic acid, histidine, tryptophan, serine, tyrosine, glycine, leucine, arginine, proline. Synthesis of the decapeptide is accomplished by coupling, in appropriate protected forms, all of the remaining amino acids, individually or in combination, to the starting amino acid, or amino acid group or to the terminal amino acid resulting from combinations with one or more other amino acids, bound to a resin or carrier followed by release of the decapeptide from the carrier as the amide or other form which is converted to the amide, L-pglutamyl-L-histidyl-L-tryptophanyl-L-seryl-L-tyrosyl-glycyl-L-leucy l-L-arginyl-L-prolyl-glycinamide.